Uitkomst raming

Toelichting

Tromboseprofylaxe bij OHSS

geen financiële gevolgen

Uit de toetsing volgt dat de aanbeveling(en) niet breed toepasbaar zijn (<5.000 patiënten) en zal daarom naar verwachting geen substantiële financiële gevolgen hebben voor de collectieve uitgaven.

Cluster/richtlijn: NVOG Ovarieel Hyperstimulatiesyndroom (OHSS)

Uitgangsvraag/modules: Wat is de plaats van tromboseprofylaxe bij patiënten met OHSS?

Database(s): Embase.com, Ovid/Medline

Datum: 20 oktober 2023

Periode: vanaf 2000

Talen: geen restrictie

Literatuurspecialist: Alies van der Wal

Rayyan review: https://rayyan.ai/reviews/821661

BMI-zoekblokken: voor verschillende opdrachten wordt (deels) gebruik gemaakt van de zoekblokken van BMI-Online https://blocks.bmi-online.nl/ Bij gebruikmaking van een volledig zoekblok zal naar de betreffende link op de website worden verwezen.

Toelichting:

Voor deze vraag is gezocht op de elementen:

• Ovarieel Hyperstimulatiesyndroom
• Tromboseprofylaxe/ antistollingstherapie

De sleutelartikelen worden gevonden met deze search

Te gebruiken voor richtlijntekst:

In de databases Embase.com en Ovid/Medline is op 30 oktober 2023 systematisch gezocht naar systematische reviews, RCTs en observationele studies over tromboseprofylaxe of antistollingstherapie bij patiënten met Ovarieel Hyperstimulatiesyndroom (OHSS). De literatuurzoekactie leverde 159 unieke treffers op.

EMBASE

OVID/MEDLINE

Ontdubbeld

SR

42

15

42

RCT

41

7

43

Observationele studies

66

31

74

Totaal

149

53

159*

No.

Query

Results

#1

'ovary hyperstimulation'/exp OR (((ovar* OR ovulation) NEAR/3 (hyperstimulation OR stimulation OR overstimulation OR induc*)):ti,ab,kw) OR ohss:ti,ab,kw OR 'in vitro fertilization'/exp OR ((('in vitro' OR extracorporeal) NEAR/3 (fertilisation OR fertilization)):ti,ab,kw) OR ivf:ti,ab,kw OR 'intracytoplasmic sperm injection'/exp OR 'intracytoplasmic sperm injection*':ti,ab,kw OR 'intra cytoplasmic sperm injection*':ti,ab,kw OR icsi:ti,ab,kw OR 'ovulation induction'/exp OR 'superovulation'/exp OR superovulation:ti,ab,kw OR 'super ovulation':ti,ab,kw OR hyperovulation:ti,ab,kw OR 'hyper ovulation':ti,ab,kw OR 'infertility therapy'/exp OR (('assisted reproduct*' NEAR/3 (techn* OR therap* OR treatment*)):ti,ab,kw) OR (((fertilit* OR infertilit*) NEAR/3 (therap* OR treatment*)):ti,ab,kw) OR (((oocyte* OR egg*) NEAR/3 (preparat* OR process* OR vitrificat* OR retriev*)):ti,ab,kw)

207655

#2

'paracentesis'/exp OR (('ascites'/exp OR 'ascites fluid'/exp OR 'effusion'/exp) AND ('aspiration, puncture and suction'/exp OR 'surgical drainage'/exp)) OR paracente*:ti,ab,kw OR 'para cente*':ti,ab,kw OR culdocente*:ti,ab,kw OR 'culdo cente*':ti,ab,kw OR colpocente*:ti,ab,kw OR peritoneocente*:ti,ab,kw OR laparocente*:ti,ab,kw OR abdominocente*:ti,ab,kw OR (((drain* OR punct* OR remov* OR aspirat* OR tap) NEAR/3 (ascit* OR ascetic OR fluid)):ti,ab,kw) OR (((abdominal OR peritoneal) NEAR/3 (centes* OR aspiration OR tap)):ti,ab,kw)

127843

#3

#1 AND #2

1938

#4

#3 NOT ('conference abstract'/it OR 'editorial'/it OR 'letter'/it OR 'note'/it) NOT (('animal'/exp OR 'animal experiment'/exp OR 'animal model'/exp OR 'nonhuman'/exp) NOT 'human'/exp)

1333

#5

#4 AND [1990-2023]/py

1257

#6

'meta analysis'/exp OR 'meta analysis (topic)'/exp OR metaanaly*:ti,ab OR 'meta analy*':ti,ab OR metanaly*:ti,ab OR 'systematic review'/de OR 'cochrane database of systematic reviews'/jt OR prisma:ti,ab OR prospero:ti,ab OR (((systemati* OR scoping OR umbrella OR 'structured literature') NEAR/3 (review* OR overview*)):ti,ab) OR ((systemic* NEAR/1 review*):ti,ab) OR (((systemati* OR literature OR database* OR 'data base*') NEAR/10 search*):ti,ab) OR (((structured OR comprehensive* OR systemic*) NEAR/3 search*):ti,ab) OR (((literature NEAR/3 review*):ti,ab) AND (search*:ti,ab OR database*:ti,ab OR 'data base*':ti,ab)) OR (('data extraction':ti,ab OR 'data source*':ti,ab) AND 'study selection':ti,ab) OR ('search strategy':ti,ab AND 'selection criteria':ti,ab) OR ('data source*':ti,ab AND 'data synthesis':ti,ab) OR medline:ab OR pubmed:ab OR embase:ab OR cochrane:ab OR (((critical OR rapid) NEAR/2 (review* OR overview* OR synthes*)):ti) OR ((((critical* OR rapid*) NEAR/3 (review* OR overview* OR synthes*)):ab) AND (search*:ab OR database*:ab OR 'data base*':ab)) OR metasynthes*:ti,ab OR 'meta synthes*':ti,ab

967213

#7

'clinical trial'/exp OR 'randomization'/exp OR 'single blind procedure'/exp OR 'double blind procedure'/exp OR 'crossover procedure'/exp OR 'placebo'/exp OR 'prospective study'/exp OR rct:ab,ti OR random*:ab,ti OR 'single blind':ab,ti OR 'randomised controlled trial':ab,ti OR 'randomized controlled trial'/exp OR placebo*:ab,ti

3879362

#8

'major clinical study'/de OR 'clinical study'/de OR 'case control study'/de OR 'family study'/de OR 'longitudinal study'/de OR 'retrospective study'/de OR 'prospective study'/de OR 'comparative study'/de OR 'cohort analysis'/de OR ((cohort NEAR/1 (study OR studies)):ab,ti) OR (('case control' NEAR/1 (study OR studies)):ab,ti) OR (('follow up' NEAR/1 (study OR studies)):ab,ti) OR (observational NEAR/1 (study OR studies)) OR ((epidemiologic NEAR/1 (study OR studies)):ab,ti) OR (('cross sectional' NEAR/1 (study OR studies)):ab,ti)

7867992

#9

'case control study'/de OR 'comparative study'/exp OR 'control group'/de OR 'controlled study'/de OR 'controlled clinical trial'/de OR 'crossover procedure'/de OR 'double blind procedure'/de OR 'phase 2 clinical trial'/de OR 'phase 3 clinical trial'/de OR 'phase 4 clinical trial'/de OR 'pretest posttest design'/de OR 'pretest posttest control group design'/de OR 'quasi experimental study'/de OR 'single blind procedure'/de OR 'triple blind procedure'/de OR (((control OR controlled) NEAR/6 trial):ti,ab,kw) OR (((control OR controlled) NEAR/6 (study OR studies)):ti,ab,kw) OR (((control OR controlled) NEAR/1 active):ti,ab,kw) OR 'open label*':ti,ab,kw OR (((double OR two OR three OR multi OR trial) NEAR/1 (arm OR arms)):ti,ab,kw) OR ((allocat* NEAR/10 (arm OR arms)):ti,ab,kw) OR placebo*:ti,ab,kw OR 'sham-control*':ti,ab,kw OR (((single OR double OR triple OR assessor) NEAR/1 (blind* OR masked)):ti,ab,kw) OR nonrandom*:ti,ab,kw OR 'non-random*':ti,ab,kw OR 'quasi-experiment*':ti,ab,kw OR crossover:ti,ab,kw OR 'cross over':ti,ab,kw OR 'parallel group*':ti,ab,kw OR 'factorial trial':ti,ab,kw OR ((phase NEAR/5 (study OR trial)):ti,ab,kw) OR ((case* NEAR/6 (matched OR control*)):ti,ab,kw) OR ((match* NEAR/6 (pair OR pairs OR cohort* OR control* OR group* OR healthy OR age OR sex OR gender OR patient* OR subject* OR participant*)):ti,ab,kw) OR ((propensity NEAR/6 (scor* OR match*)):ti,ab,kw) OR versus:ti OR vs:ti OR compar*:ti OR ((compar* NEAR/1 study):ti,ab,kw) OR (('major clinical study'/de OR 'clinical study'/de OR 'cohort analysis'/de OR 'observational study'/de OR 'cross-sectional study'/de OR 'multicenter study'/de OR 'correlational study'/de OR 'follow up'/de OR cohort*:ti,ab,kw OR 'follow up':ti,ab,kw OR followup:ti,ab,kw OR longitudinal*:ti,ab,kw OR prospective*:ti,ab,kw OR retrospective*:ti,ab,kw OR observational*:ti,ab,kw OR 'cross sectional*':ti,ab,kw OR cross?ectional*:ti,ab,kw OR multicent*:ti,ab,kw OR 'multi-cent*':ti,ab,kw OR consecutive*:ti,ab,kw) AND (group:ti,ab,kw OR groups:ti,ab,kw OR subgroup*:ti,ab,kw OR versus:ti,ab,kw OR vs:ti,ab,kw OR compar*:ti,ab,kw OR 'odds ratio*':ab OR 'relative odds':ab OR 'risk ratio*':ab OR 'relative risk*':ab OR 'rate ratio':ab OR aor:ab OR arr:ab OR rrr:ab OR ((('or' OR 'rr') NEAR/6 ci):ab)))

14472008

#10

#5 AND #6 – SR

55

#11

#5 AND #7 NOT #10 – RCT

121

#12

#5 AND (#8 OR #9) NOT (#10 OR #11) – Observationeel

359

#13

#10 OR #11 OR #12

535

#

Searches

Results

1

Ovarian Hyperstimulation Syndrome/ or ((ovar* or ovulation) adj3 (hyperstimulation or stimulation or overstimulation or induc*)).ti,ab,kf. or ohss.ti,ab,kf. or exp Fertilization in Vitro/ or ((in vitro or extracorporeal) adj3 (fertilisation or fertilization)).ti,ab,kf. or ivf.ti,ab,kf. or exp sperm injections, intracytoplasmic/ or intracytoplasmic sperm injection*.ti,ab,kf. or intra cytoplasmic sperm injection*.ti,ab,kf. or icsi.ti,ab,kf. or exp Ovulation Induction/ or exp superovulation/ or superovulation.ti,ab,kf. or super ovulation.ti,ab,kf. or hyperovulation.ti,ab,kf. or hyper ovulation.ti,ab,kf. or (assisted reproduct* adj3 (techn* or therap* or treatment*)).ti,ab,kf. or ((fertilit* or infertilit*) adj3 (therap* or treatment*)).ti,ab,kf. or ((oocyte* or egg*) adj3 (preparat* or process* or vitrificat* or retriev*)).ti,ab,kf.

101531

2

exp Paracentesis/ or ((Ascites/ or Ascitic Fluid/) and (exp Drainage/ or Endoscopic Ultrasound-Guided Fine Needle Aspiration/)) or paracente*.ti,ab,kf. or para cente*.ti,ab,kf. or culdocente*.ti,ab,kf. or culdo cente*.ti,ab,kf. or colpocente*.ti,ab,kf. or peritoneocente*.ti,ab,kf. or laparocente*.ti,ab,kf. or abdominocente*.ti,ab,kf. or ((drain* or punct* or remov* or aspirat* or tap) adj3 (ascit* or ascetic or fluid)).ti,ab,kf. or ((abdominal or peritoneal) adj3 (centes* or aspiration or tap)).ti,ab,kf.

31157

3

1 and 2

537

4

3 not (comment/ or editorial/ or letter/) not ((exp animals/ or exp models, animal/) not humans/)

493

5

limit 4 to yr=1990-2023

436

6

meta-analysis/ or meta-analysis as topic/ or (metaanaly* or meta-analy* or metanaly*).ti,ab,kf. or systematic review/ or cochrane.jw. or (prisma or prospero).ti,ab,kf. or ((systemati* or scoping or umbrella or "structured literature") adj3 (review* or overview*)).ti,ab,kf. or (systemic* adj1 review*).ti,ab,kf. or ((systemati* or literature or database* or data-base*) adj10 search*).ti,ab,kf. or ((structured or comprehensive* or systemic*) adj3 search*).ti,ab,kf. or ((literature adj3 review*) and (search* or database* or data-base*)).ti,ab,kf. or (("data extraction" or "data source*") and "study selection").ti,ab,kf. or ("search strategy" and "selection criteria").ti,ab,kf. or ("data source*" and "data synthesis").ti,ab,kf. or (medline or pubmed or embase or cochrane).ab. or ((critical or rapid) adj2 (review* or overview* or synthes*)).ti. or (((critical* or rapid*) adj3 (review* or overview* or synthes*)) and (search* or database* or data-base*)).ab. or (metasynthes* or meta-synthes*).ti,ab,kf.

697610

7

exp clinical trial/ or randomized controlled trial/ or exp clinical trials as topic/ or randomized controlled trials as topic/ or Random Allocation/ or Double-Blind Method/ or Single-Blind Method/ or (clinical trial, phase i or clinical trial, phase ii or clinical trial, phase iii or clinical trial, phase iv or controlled clinical trial or randomized controlled trial or multicenter study or clinical trial).pt. or random*.ti,ab. or (clinic* adj trial*).tw. or ((singl* or doubl* or treb* or tripl*) adj (blind$3 or mask$3)).tw. or Placebos/ or placebo*.tw.

2640644

8

Epidemiologic studies/ or case control studies/ or exp cohort studies/ or Controlled Before-After Studies/ or Case control.tw. or cohort.tw. or Cohort analy$.tw. or (Follow up adj (study or studies)).tw. or (observational adj (study or studies)).tw. or Longitudinal.tw. or Retrospective*.tw. or prospective*.tw. or consecutive*.tw. or Cross sectional.tw. or Cross-sectional studies/ or historically controlled study/ or interrupted time series analysis/ [Onder exp cohort studies vallen ook longitudinale, prospectieve en retrospectieve studies]

4548180

9

Case-control Studies/ or clinical trial, phase ii/ or clinical trial, phase iii/ or clinical trial, phase iv/ or comparative study/ or control groups/ or controlled before-after studies/ or controlled clinical trial/ or double-blind method/ or historically controlled study/ or matched-pair analysis/ or single-blind method/ or (((control or controlled) adj6 (study or studies or trial)) or (compar* adj (study or studies)) or ((control or controlled) adj1 active) or "open label*" or ((double or two or three or multi or trial) adj (arm or arms)) or (allocat* adj10 (arm or arms)) or placebo* or "sham-control*" or ((single or double or triple or assessor) adj1 (blind* or masked)) or nonrandom* or "non-random*" or "quasi-experiment*" or "parallel group*" or "factorial trial" or "pretest posttest" or (phase adj5 (study or trial)) or (case* adj6 (matched or control*)) or (match* adj6 (pair or pairs or cohort* or control* or group* or healthy or age or sex or gender or patient* or subject* or participant*)) or (propensity adj6 (scor* or match*))).ti,ab,kf. or (confounding adj6 adjust*).ti,ab. or (versus or vs or compar*).ti. or ((exp cohort studies/ or epidemiologic studies/ or multicenter study/ or observational study/ or seroepidemiologic studies/ or (cohort* or 'follow up' or followup or longitudinal* or prospective* or retrospective* or observational* or multicent* or 'multi-cent*' or consecutive*).ti,ab,kf.) and ((group or groups or subgroup* or versus or vs or compar*).ti,ab,kf. or ('odds ratio*' or 'relative odds' or 'risk ratio*' or 'relative risk*' or aor or arr or rrr).ab. or (("OR" or "RR") adj6 CI).ab.))

5526305

10

5 and 6 – SR

22

11

(5 and 7) not 10 – RCT

37

12

(5 and (8 or 9)) not (10 or 11) – Observationeel

127

13

10 or 11 or 12

186

No.

Query

Results

#1

'ovary hyperstimulation'/exp OR (((hyperstimulation* OR 'hyper stimulation*') NEAR/3 syndrome*):ti,ab,kw) OR ohss:ti,ab,kw

13238

#2

'thrombosis prevention'/exp OR 'embolism prevention'/exp OR 'anticoagulant therapy'/exp OR 'anticoagulant agent'/exp/mj OR 'anticoagulation'/exp OR (('prophylaxis'/de OR 'prevention'/exp/mj) AND 'thromboembolism'/exp) OR (((thrombo* OR embolism* OR 'blood clot*' OR vte OR dvt) NEAR/3 (prevent* OR prophyla*)):ti,ab,kw) OR thromboprophyla*:ti,ab,kw OR antithrombo*:ti,ab,kw OR 'anti thrombo*':ti,ab,kw OR anticoagula*:ti,ab,kw OR 'anti coagula*':ti,ab,kw OR doac*:ti,ab,kw OR antithrombin*:ti,ab,kw OR 'anti thrombin*':ti,ab,kw OR ((('blood clot*' OR thrombin*) NEAR/3 inhibit*):ti,ab,kw) OR 'low molecular weight heparin'/exp OR 'heparin'/exp OR heparin*:ti,ab,kw OR 'dalteparin'/exp OR 'dalteparin*':ti,ab,kw OR 'fragmin*':ti,ab,kw OR 'acetylsalicylic acid'/exp/mj OR 'acetylsalicylic acid':ti,ab,kw OR 'aspirin*':ti,ab,kw OR 'clopidogrel'/exp OR 'clopidogrel':ti,ab,kw OR 'plavix':ti,ab,kw OR 'dipyridamole'/exp OR 'dipyridamol*':ti,ab,kw OR 'persantin':ti,ab,kw OR 'vitamin k antagonists'/exp OR 'antivitamin k'/exp OR 'anti vitamin k':ti,ab,kw OR 'antivitamin k':ti,ab,kw OR 'vitamin k antagonist*':ti,ab,kw OR 'coumarin anticoagulant'/exp OR coumarin*:ti,ab,kw OR 'acenocoumarin*':ti,ab,kw OR 'acenocoumarol':ti,ab,kw OR 'fenprocoumon':ti,ab,kw OR 'phenprocoumon':ti,ab,kw OR 'marcoumar':ti,ab,kw OR 'direct oral anticoagulant'/exp OR 'direct oral anticoagulant agent'/exp OR 'dabigatran'/exp OR 'dabigatran':ti,ab,kw OR 'apixaban'/exp OR 'apixaban':ti,ab,kw OR 'eliques':ti,ab,kw OR 'edoxaban'/exp OR 'edoxaban':ti,ab,kw OR 'lixiana':ti,ab,kw OR 'rivaroxaban'/exp OR 'rivaroxaban':ti,ab,kw OR 'xarelto':ti,ab,kw

768877

#3

#1 AND #2

607

#4

#3 NOT ('conference abstract'/it OR 'editorial'/it OR 'letter'/it OR 'note'/it) NOT (('animal'/exp OR 'animal experiment'/exp OR 'animal model'/exp OR 'nonhuman'/exp) NOT 'human'/exp)

487

#5

#4 AND [2000-2023]/py

420

#6

'meta analysis'/exp OR 'meta analysis (topic)'/exp OR metaanaly*:ti,ab OR 'meta analy*':ti,ab OR metanaly*:ti,ab OR 'systematic review'/de OR 'cochrane database of systematic reviews'/jt OR prisma:ti,ab OR prospero:ti,ab OR (((systemati* OR scoping OR umbrella OR 'structured literature') NEAR/3 (review* OR overview*)):ti,ab) OR ((systemic* NEAR/1 review*):ti,ab) OR (((systemati* OR literature OR database* OR 'data base*') NEAR/10 search*):ti,ab) OR (((structured OR comprehensive* OR systemic*) NEAR/3 search*):ti,ab) OR (((literature NEAR/3 review*):ti,ab) AND (search*:ti,ab OR database*:ti,ab OR 'data base*':ti,ab)) OR (('data extraction':ti,ab OR 'data source*':ti,ab) AND 'study selection':ti,ab) OR ('search strategy':ti,ab AND 'selection criteria':ti,ab) OR ('data source*':ti,ab AND 'data synthesis':ti,ab) OR medline:ab OR pubmed:ab OR embase:ab OR cochrane:ab OR (((critical OR rapid) NEAR/2 (review* OR overview* OR synthes*)):ti) OR ((((critical* OR rapid*) NEAR/3 (review* OR overview* OR synthes*)):ab) AND (search*:ab OR database*:ab OR 'data base*':ab)) OR metasynthes*:ti,ab OR 'meta synthes*':ti,ab

971743

#7

'clinical trial'/exp OR 'randomization'/exp OR 'single blind procedure'/exp OR 'double blind procedure'/exp OR 'crossover procedure'/exp OR 'placebo'/exp OR 'prospective study'/exp OR rct:ab,ti OR random*:ab,ti OR 'single blind':ab,ti OR 'randomised controlled trial':ab,ti OR 'randomized controlled trial'/exp OR placebo*:ab,ti

3899513

#8

'major clinical study'/de OR 'clinical study'/de OR 'case control study'/de OR 'family study'/de OR 'longitudinal study'/de OR 'retrospective study'/de OR 'prospective study'/de OR 'comparative study'/de OR 'cohort analysis'/de OR ((cohort NEAR/1 (study OR studies)):ab,ti) OR (('case control' NEAR/1 (study OR studies)):ab,ti) OR (('follow up' NEAR/1 (study OR studies)):ab,ti) OR (observational NEAR/1 (study OR studies)) OR ((epidemiologic NEAR/1 (study OR studies)):ab,ti) OR (('cross sectional' NEAR/1 (study OR studies)):ab,ti)

7896298

#9

'case control study'/de OR 'comparative study'/exp OR 'control group'/de OR 'controlled study'/de OR 'controlled clinical trial'/de OR 'crossover procedure'/de OR 'double blind procedure'/de OR 'phase 2 clinical trial'/de OR 'phase 3 clinical trial'/de OR 'phase 4 clinical trial'/de OR 'pretest posttest design'/de OR 'pretest posttest control group design'/de OR 'quasi experimental study'/de OR 'single blind procedure'/de OR 'triple blind procedure'/de OR (((control OR controlled) NEAR/6 trial):ti,ab,kw) OR (((control OR controlled) NEAR/6 (study OR studies)):ti,ab,kw) OR (((control OR controlled) NEAR/1 active):ti,ab,kw) OR 'open label*':ti,ab,kw OR (((double OR two OR three OR multi OR trial) NEAR/1 (arm OR arms)):ti,ab,kw) OR ((allocat* NEAR/10 (arm OR arms)):ti,ab,kw) OR placebo*:ti,ab,kw OR 'sham-control*':ti,ab,kw OR (((single OR double OR triple OR assessor) NEAR/1 (blind* OR masked)):ti,ab,kw) OR nonrandom*:ti,ab,kw OR 'non-random*':ti,ab,kw OR 'quasi-experiment*':ti,ab,kw OR crossover:ti,ab,kw OR 'cross over':ti,ab,kw OR 'parallel group*':ti,ab,kw OR 'factorial trial':ti,ab,kw OR ((phase NEAR/5 (study OR trial)):ti,ab,kw) OR ((case* NEAR/6 (matched OR control*)):ti,ab,kw) OR ((match* NEAR/6 (pair OR pairs OR cohort* OR control* OR group* OR healthy OR age OR sex OR gender OR patient* OR subject* OR participant*)):ti,ab,kw) OR ((propensity NEAR/6 (scor* OR match*)):ti,ab,kw) OR versus:ti OR vs:ti OR compar*:ti OR ((compar* NEAR/1 study):ti,ab,kw) OR (('major clinical study'/de OR 'clinical study'/de OR 'cohort analysis'/de OR 'observational study'/de OR 'cross-sectional study'/de OR 'multicenter study'/de OR 'correlational study'/de OR 'follow up'/de OR cohort*:ti,ab,kw OR 'follow up':ti,ab,kw OR followup:ti,ab,kw OR longitudinal*:ti,ab,kw OR prospective*:ti,ab,kw OR retrospective*:ti,ab,kw OR observational*:ti,ab,kw OR 'cross sectional*':ti,ab,kw OR cross?ectional*:ti,ab,kw OR multicent*:ti,ab,kw OR 'multi-cent*':ti,ab,kw OR consecutive*:ti,ab,kw) AND (group:ti,ab,kw OR groups:ti,ab,kw OR subgroup*:ti,ab,kw OR versus:ti,ab,kw OR vs:ti,ab,kw OR compar*:ti,ab,kw OR 'odds ratio*':ab OR 'relative odds':ab OR 'risk ratio*':ab OR 'relative risk*':ab OR 'rate ratio':ab OR aor:ab OR arr:ab OR rrr:ab OR ((('or' OR 'rr') NEAR/6 ci):ab)))

14518696

#10

#5 AND #6 = SR

42

#11

#5 AND #7 NOT #10 = RCT

41

#12

#5 AND (#8 OR #9) NOT (#10 OR #11) = observationeel

66

#13

#10 OR #11 OR #12

149

#

Searches

Results

1

exp Ovarian Hyperstimulation Syndrome/ or ((hyperstimulation* or 'hyper stimulation*') adj3 syndrome*).ti,ab,kf. or ohss.ti,ab,kf.

4289

2

exp Anticoagulants/ or ((prophyla* or 'prevent*).ti,ab,kf. and exp "Embolism and Thrombosis"/) or ((thrombo* or embolism* or 'blood clot*' or vte or dvt) adj3 (prevent* or prophyla*)).ti,ab,kf. or thromboprophyla*.ti,ab,kf. or antithrombo*.ti,ab,kf. or 'anti thrombo*'.ti,ab,kf. or anticoagula*.ti,ab,kf. or 'anti coagula*'.ti,ab,kf. or doac*.ti,ab,kf. or antithrombin*.ti,ab,kf. or 'anti thrombin*'.ti,ab,kf. or (('blood clot*' or thrombin*) adj3 inhibit*).ti,ab,kf. or exp Heparin/ or heparin*.ti,ab,kf. or exp Dalteparin/ or 'dalteparin*'.ti,ab,kf. or 'fragmin*'.ti,ab,kf. or exp Aspirin/ or 'acetylsalicylic acid'.ti,ab,kf. or 'aspirin*'.ti,ab,kf. or exp Clopidogrel/ or 'clopidogrel'.ti,ab,kf. or 'plavix'.ti,ab,kf. or exp Dipyridamole/ or 'dipyridamol*'.ti,ab,kf. or 'persantin'.ti,ab,kf. or 'anti vitamin k'.ti,ab,kf. or 'antivitamin k'.ti,ab,kf. or 'vitamin k antagonist*'.ti,ab,kf. or exp Acenocoumarol/ or exp Phenprocoumon/ or coumarin*.ti,ab,kf. or 'acenocoumarin*'.ti,ab,kf. or 'acenocoumarol'.ti,ab,kf. or 'fenprocoumon'.ti,ab,kf. or 'phenprocoumon'.ti,ab,kf. or 'marcoumar'.ti,ab,kf. or exp Dabigatran/ or 'dabigatran'.ti,ab,kf. or 'apixaban'.ti,ab,kf. or 'eliques'.ti,ab,kf. or 'edoxaban'.ti,ab,kf. or 'lixiana'.ti,ab,kf. or exp Rivaroxaban/ or 'rivaroxaban'.ti,ab,kf. or 'xarelto'.ti,ab,kf.

461482

3

1 and 2

213

4

3 not (comment/ or editorial/ or letter/) not ((exp animals/ or exp models, animal/) not humans/)

203

5

limit 4 to yr="2000 -Current"

166

6

meta-analysis/ or meta-analysis as topic/ or (metaanaly* or meta-analy* or metanaly*).ti,ab,kf. or systematic review/ or cochrane.jw. or (prisma or prospero).ti,ab,kf. or ((systemati* or scoping or umbrella or "structured literature") adj3 (review* or overview*)).ti,ab,kf. or (systemic* adj1 review*).ti,ab,kf. or ((systemati* or literature or database* or data-base*) adj10 search*).ti,ab,kf. or ((structured or comprehensive* or systemic*) adj3 search*).ti,ab,kf. or ((literature adj3 review*) and (search* or database* or data-base*)).ti,ab,kf. or (("data extraction" or "data source*") and "study selection").ti,ab,kf. or ("search strategy" and "selection criteria").ti,ab,kf. or ("data source*" and "data synthesis").ti,ab,kf. or (medline or pubmed or embase or cochrane).ab. or ((critical or rapid) adj2 (review* or overview* or synthes*)).ti. or (((critical* or rapid*) adj3 (review* or overview* or synthes*)) and (search* or database* or data-base*)).ab. or (metasynthes* or meta-synthes*).ti,ab,kf.

702237

7

exp clinical trial/ or randomized controlled trial/ or exp clinical trials as topic/ or randomized controlled trials as topic/ or Random Allocation/ or Double-Blind Method/ or Single-Blind Method/ or (clinical trial, phase i or clinical trial, phase ii or clinical trial, phase iii or clinical trial, phase iv or controlled clinical trial or randomized controlled trial or multicenter study or clinical trial).pt. or random*.ti,ab. or (clinic* adj trial*).tw. or ((singl* or doubl* or treb* or tripl*) adj (blind$3 or mask$3)).tw. or Placebos/ or placebo*.tw.

2647730

8

Epidemiologic studies/ or case control studies/ or exp cohort studies/ or Controlled Before-After Studies/ or Case control.tw. or cohort.tw. or Cohort analy$.tw. or (Follow up adj (study or studies)).tw. or (observational adj (study or studies)).tw. or Longitudinal.tw. or Retrospective*.tw. or prospective*.tw. or consecutive*.tw. or Cross sectional.tw. or Cross-sectional studies/ or historically controlled study/ or interrupted time series analysis/ [Onder exp cohort studies vallen ook longitudinale, prospectieve en retrospectieve studies]

4562871

9

Case-control Studies/ or clinical trial, phase ii/ or clinical trial, phase iii/ or clinical trial, phase iv/ or comparative study/ or control groups/ or controlled before-after studies/ or controlled clinical trial/ or double-blind method/ or historically controlled study/ or matched-pair analysis/ or single-blind method/ or (((control or controlled) adj6 (study or studies or trial)) or (compar* adj (study or studies)) or ((control or controlled) adj1 active) or "open label*" or ((double or two or three or multi or trial) adj (arm or arms)) or (allocat* adj10 (arm or arms)) or placebo* or "sham-control*" or ((single or double or triple or assessor) adj1 (blind* or masked)) or nonrandom* or "non-random*" or "quasi-experiment*" or "parallel group*" or "factorial trial" or "pretest posttest" or (phase adj5 (study or trial)) or (case* adj6 (matched or control*)) or (match* adj6 (pair or pairs or cohort* or control* or group* or healthy or age or sex or gender or patient* or subject* or participant*)) or (propensity adj6 (scor* or match*))).ti,ab,kf. or (confounding adj6 adjust*).ti,ab. or (versus or vs or compar*).ti. or ((exp cohort studies/ or epidemiologic studies/ or multicenter study/ or observational study/ or seroepidemiologic studies/ or (cohort* or 'follow up' or followup or longitudinal* or prospective* or retrospective* or observational* or multicent* or 'multi-cent*' or consecutive*).ti,ab,kf.) and ((group or groups or subgroup* or versus or vs or compar*).ti,ab,kf. or ('odds ratio*' or 'relative odds' or 'risk ratio*' or 'relative risk*' or aor or arr or rrr).ab. or (("OR" or "RR") adj6 CI).ab.))

5540050

10

5 and 6 = SR

15

11

(5 and 7) not 10 = RCT

7

12

(5 and (8 or 9)) not (10 or 11) = observationeel

31

13

10 or 11 or 12

53