Module

Uitkomst raming

Toelichting

Leefstijlinterventies

Geen financiele gevolgen.

Uit de toetsing volgt dat de aanbevelingen niet breed toepasbaar zijn (<5.000 patiënten) en daarom naar verwachting geen substantiële financiële gevolgen zullen hebben voor de collectieve uitgaven.

EMBASE

OVID/MEDLINE

Ontdubbeld

SR

651

432

792

RCT

1117

856

1633

Observationeel

3855

1660

4391

Totaal

5623

2948

6816

No.

Query

Results

#1

'male infertility'/exp OR 'male fertility'/exp OR (('subfertility'/de OR 'childlessness'/exp) AND 'male'/exp) OR (((male* OR men OR man) NEAR/3 (infertil* OR hypofertil* OR 'fertil*' OR subfertil* OR infecund* OR childless* OR reproduct*)):ti,ab,kw) OR (((spermatogen* OR spermiation OR spermiogen*) NEAR/3 failure):ti,ab,kw) OR ((spermatozoon NEAR/3 (abnormalit* OR anomal*)):ti,ab,kw) OR (((semen OR sperm) NEAR/3 (qualit* OR quantit* OR parameter*)):ti,ab,kw) OR asperm*:ti,ab,kw OR asthenazoosperm*:ti,ab,kw OR asthenosperm*:ti,ab,kw OR asthenozoosperm*:ti,ab,kw OR azoosperm*:ti,ab,kw OR cryptosperm*:ti,ab,kw OR cryptozoosperm*:ti,ab,kw OR hyposperm*:ti,ab,kw OR oligoasthenosperm*:ti,ab,kw OR oligosperm*:ti,ab,kw OR oligozoosperm*:ti,ab,kw OR 'retrograde ejaculat*':ti,ab,kw OR 'sco syndrome*':ti,ab,kw OR 'sertoli cell only syndrome*':ti,ab,kw OR teratozoosperm*:ti,ab,kw OR 'thermosensitive genic male steril*':ti,ab,kw OR globozoosperm*:ti,ab,kw OR macrozoosperm*:ti,ab,kw

111014

#2

'lifestyle'/exp OR 'lifestyle modification'/exp OR 'lifestyle intervention'/exp OR 'exercise'/exp OR 'diet'/exp OR 'alternative medicine'/exp OR 'diet therapy'/exp OR 'dietary supplement'/exp OR 'supplementation'/exp OR 'mindfulness'/exp OR 'sport'/exp OR 'meditation'/exp OR 'sleep'/exp OR 'relaxation training'/exp OR 'multivitamin'/exp OR 'stress management'/exp OR 'coaching'/exp OR 'body mass'/exp OR 'body weight change'/exp OR 'obesity'/exp OR 'food'/exp OR 'beverage'/exp OR (('fitness' NEAR/3 ('training' OR 'workout')):ti,ab,kw) OR (('physical' NEAR/3 ('effort*' OR 'exertion' OR 'work-out' OR 'workout')):ti,ab,kw) OR (('nutrition' NEAR/3 ('intervention*' OR 'therap*' OR 'treatment*')):ti,ab,kw) OR (((relaxation OR complementary) NEAR/2 ('method*' OR 'techni*' OR 'therap*' OR 'training')):ti,ab,kw) OR ((('anxiety' OR 'stress' OR 'fear') NEAR/2 ('manag*' OR 'strateg*' OR 'therap*' OR 'reduc*')):ti,ab,kw) OR ((('nutrition*' OR 'food') NEAR/3 ('therap*' OR 'intervention*' OR 'treatment*' OR 'advice*' OR 'supplement*' OR 'additive*')):ti,ab,kw) OR ((('oral' OR 'food' OR 'multinutrient*' OR 'multi nutrient*' OR 'vitamin*') NEAR/3 'supplement*'):ti,ab,kw) OR ((weight NEAR/3 (decreas* OR los* OR reduc* OR watching)):ti,ab,kw) OR 'life style*':ti,ab,kw OR lifestyle*:ti,ab,kw OR coaching:ti,ab,kw OR nutrition:ti,ab,kw OR diet*:ti,ab,kw OR 'exercis*':ti,ab,kw OR 'supplement*':ti,ab,kw OR 'mindfulness':ti,ab,kw OR 'yoga':ti,ab,kw OR 'meditation':ti,ab,kw OR 'sleep*':ti,ab,kw OR 'coffea':ti,ab,kw OR 'coffee':ti,ab,kw OR 'diet*':ti,ab,kw OR 'dietar*':ti,ab,kw OR 'dietetic*':ti,ab,kw OR 'dietic*':ti,ab,kw OR 'dietit*':ti,ab,kw OR 'multivitamin*':ti,ab,kw OR bmi:ti,ab,kw OR 'body mass*':ti,ab,kw OR adipos*:ti,ab,kw OR obesity*:ti,ab,kw OR corpulenc*:ti,ab,kw OR overweight*:ti,ab,kw

5546963

#3

#1 AND #2

18689

#4

#3 AND [2000-2024]/py NOT ('conference abstract'/it OR 'editorial'/it OR 'letter'/it OR 'note'/it) NOT (('animal'/exp OR 'animal experiment'/exp OR 'animal model'/exp OR 'nonhuman'/exp) NOT 'human'/exp)

6957

#5

'meta analysis'/exp OR 'meta analysis (topic)'/exp OR metaanaly*:ti,ab OR 'meta analy*':ti,ab OR metanaly*:ti,ab OR 'systematic review'/de OR 'cochrane database of systematic reviews'/jt OR prisma:ti,ab OR prospero:ti,ab OR (((systemati* OR scoping OR umbrella OR 'structured literature') NEAR/3 (review* OR overview*)):ti,ab) OR ((systemic* NEAR/1 review*):ti,ab) OR (((systemati* OR literature OR database* OR 'data base*') NEAR/10 search*):ti,ab) OR (((structured OR comprehensive* OR systemic*) NEAR/3 search*):ti,ab) OR (((literature NEAR/3 review*):ti,ab) AND (search*:ti,ab OR database*:ti,ab OR 'data base*':ti,ab)) OR (('data extraction':ti,ab OR 'data source*':ti,ab) AND 'study selection':ti,ab) OR ('search strategy':ti,ab AND 'selection criteria':ti,ab) OR ('data source*':ti,ab AND 'data synthesis':ti,ab) OR medline:ab OR pubmed:ab OR embase:ab OR cochrane:ab OR (((critical OR rapid) NEAR/2 (review* OR overview* OR synthes*)):ti) OR ((((critical* OR rapid*) NEAR/3 (review* OR overview* OR synthes*)):ab) AND (search*:ab OR database*:ab OR 'data base*':ab)) OR metasynthes*:ti,ab OR 'meta synthes*':ti,ab

1015572

#6

'clinical trial'/exp OR 'randomization'/exp OR 'single blind procedure'/exp OR 'double blind procedure'/exp OR 'crossover procedure'/exp OR 'placebo'/exp OR 'prospective study'/exp OR rct:ab,ti OR random*:ab,ti OR 'single blind':ab,ti OR 'randomised controlled trial':ab,ti OR 'randomized controlled trial'/exp OR placebo*:ab,ti

4003546

#7

'major clinical study'/de OR 'clinical study'/de OR 'case control study'/de OR 'family study'/de OR 'longitudinal study'/de OR 'retrospective study'/de OR 'prospective study'/de OR 'comparative study'/de OR 'cohort analysis'/de OR ((cohort NEAR/1 (study OR studies)):ab,ti) OR (('case control' NEAR/1 (study OR studies)):ab,ti) OR (('follow up' NEAR/1 (study OR studies)):ab,ti) OR (observational NEAR/1 (study OR studies)) OR ((epidemiologic NEAR/1 (study OR studies)):ab,ti) OR (('cross sectional' NEAR/1 (study OR studies)):ab,ti)

8152930

#8

'case control study'/de OR 'comparative study'/exp OR 'control group'/de OR 'controlled study'/de OR 'controlled clinical trial'/de OR 'crossover procedure'/de OR 'double blind procedure'/de OR 'phase 2 clinical trial'/de OR 'phase 3 clinical trial'/de OR 'phase 4 clinical trial'/de OR 'pretest posttest design'/de OR 'pretest posttest control group design'/de OR 'quasi experimental study'/de OR 'single blind procedure'/de OR 'triple blind procedure'/de OR (((control OR controlled) NEAR/6 trial):ti,ab,kw) OR (((control OR controlled) NEAR/6 (study OR studies)):ti,ab,kw) OR (((control OR controlled) NEAR/1 active):ti,ab,kw) OR 'open label*':ti,ab,kw OR (((double OR two OR three OR multi OR trial) NEAR/1 (arm OR arms)):ti,ab,kw) OR ((allocat* NEAR/10 (arm OR arms)):ti,ab,kw) OR placebo*:ti,ab,kw OR 'sham-control*':ti,ab,kw OR (((single OR double OR triple OR assessor) NEAR/1 (blind* OR masked)):ti,ab,kw) OR nonrandom*:ti,ab,kw OR 'non-random*':ti,ab,kw OR 'quasi-experiment*':ti,ab,kw OR crossover:ti,ab,kw OR 'cross over':ti,ab,kw OR 'parallel group*':ti,ab,kw OR 'factorial trial':ti,ab,kw OR ((phase NEAR/5 (study OR trial)):ti,ab,kw) OR ((case* NEAR/6 (matched OR control*)):ti,ab,kw) OR ((match* NEAR/6 (pair OR pairs OR cohort* OR control* OR group* OR healthy OR age OR sex OR gender OR patient* OR subject* OR participant*)):ti,ab,kw) OR ((propensity NEAR/6 (scor* OR match*)):ti,ab,kw) OR versus:ti OR vs:ti OR compar*:ti OR ((compar* NEAR/1 study):ti,ab,kw) OR (('major clinical study'/de OR 'clinical study'/de OR 'cohort analysis'/de OR 'observational study'/de OR 'cross-sectional study'/de OR 'multicenter study'/de OR 'correlational study'/de OR 'follow up'/de OR cohort*:ti,ab,kw OR 'follow up':ti,ab,kw OR followup:ti,ab,kw OR longitudinal*:ti,ab,kw OR prospective*:ti,ab,kw OR retrospective*:ti,ab,kw OR observational*:ti,ab,kw OR 'cross sectional*':ti,ab,kw OR cross?ectional*:ti,ab,kw OR multicent*:ti,ab,kw OR 'multi-cent*':ti,ab,kw OR consecutive*:ti,ab,kw) AND (group:ti,ab,kw OR groups:ti,ab,kw OR subgroup*:ti,ab,kw OR versus:ti,ab,kw OR vs:ti,ab,kw OR compar*:ti,ab,kw OR 'odds ratio*':ab OR 'relative odds':ab OR 'risk ratio*':ab OR 'relative risk*':ab OR 'rate ratio':ab OR aor:ab OR arr:ab OR rrr:ab OR ((('or' OR 'rr') NEAR/6 ci):ab)))

14958439

#9

#4 AND #5 - SR’s

651

#10

#4 AND #6 NOT #9 – RCT’s

1117

#11

#4 AND (7 OR #8) NOT (#9 OR #10) – Observationele studies

3855

#12

#9 OR #10 OR #11

5623

#

Searches

Results

1

exp Infertility, Male/ or ((exp Infertility/ or Fertility/) and exp Male/) or ((male* or men or man) adj3 (infertil* or hypofertil* or fertil* or subfertil* or infecund* or childless* or reproduct*)).ti,ab,kf. or ((spermatogen* or spermiation or spermiogen*) adj3 failure).ti,ab,kf. or (spermatozoon adj3 (abnormalit* or anomal*)).ti,ab,kf. or ((semen or sperm) adj3 (qualit* or quantit*)).ti,ab,kf. or asperm*.ti,ab,kf. or asthenazoosperm*.ti,ab,kf. or asthenosperm*.ti,ab,kf. or asthenozoosperm*.ti,ab,kf. or azoosperm*.ti,ab,kf. or cryptosperm*.ti,ab,kf. or cryptozoosperm*.ti,ab,kf. or hyposperm*.ti,ab,kf. or oligoasthenosperm*.ti,ab,kf. or oligosperm*.ti,ab,kf. or oligozoosperm*.ti,ab,kf. or retrograde ejaculat*.ti,ab,kf. or sco syndrome*.ti,ab,kf. or sertoli cell only syndrome*.ti,ab,kf. or teratozoosperm*.ti,ab,kf. or thermosensitive genic male steril*.ti,ab,kf. or globozoosperm*.ti,ab,kf. or macrozoosperm*.ti,ab,kf.

97622

2

exp Life Style/ or exp Exercise/ or exp Diet/ or exp Complementary Therapies/ or exp Dietary Supplements/ or exp Mindfulness/ or exp Mind-Body Therapies/ or exp Relaxation Therapy/ or exp Sleep/ or exp "Diet, Food, and Nutrition"/ or exp Vitamins/ or exp Mentoring/ or exp Obesity/ or exp Body Mass Index/ or exp Body Weight Changes/ or (fitness adj3 (training or workout)).ti,ab,kf. or (physical adj3 (effort* or exertion or work-out or workout)).ti,ab,kf. or (nutrition adj3 (intervention* or therap* or treatment*)).ti,ab,kf. or ((relaxation or complementary) adj2 (method* or techni* or therap* or training)).ti,ab,kf. or ((anxiety or stress or fear) adj2 (manag* or strateg* or therap* or reduc*)).ti,ab,kf. or ((nutrition* or food) adj3 (therap* or intervention* or treatment* or advice* or supplement* or additive*)).ti,ab,kf. or ((oral or food or multinutrient* or multi nutrient* or vitamin*) adj3 supplement*).ti,ab,kf. or (weight adj3 (decreas* or los* or reduc* or watching)).ti,ab,kf. or life style*.ti,ab,kf. or lifestyle*.ti,ab,kf. or coaching.ti,ab,kf. or nutrition.ti,ab,kf. or diet*.ti,ab,kf. or exercis*.ti,ab,kf. or supplement*.ti,ab,kf. or mindfulness.ti,ab,kf. or yoga.ti,ab,kf. or meditation.ti,ab,kf. or sleep*.ti,ab,kf. or coffea.ti,ab,kf. or coffee.ti,ab,kf. or diet*.ti,ab,kf. or dietar*.ti,ab,kf. or dietetic*.ti,ab,kf. or dietic*.ti,ab,kf. or dietit*.ti,ab,kf. or multivitamin*.ti,ab,kf. or bmi.ti,ab,kf. or body mass*.ti,ab,kf. or adipos*.ti,ab,kf. or obesity*.ti,ab,kf. or corpulenc*.ti,ab,kf. or overweight*.ti,ab,kf.

4472501

3

1 and 2

14276

4

limit 3 to yr="2000 -Current"

11260

5

4 not (comment/ or editorial/ or letter/) not ((exp animals/ or exp models, animal/) not humans/)

6265

6

meta-analysis/ or meta-analysis as topic/ or (metaanaly* or meta-analy* or metanaly*).ti,ab,kf. or systematic review/ or cochrane.jw. or (prisma or prospero).ti,ab,kf. or ((systemati* or scoping or umbrella or "structured literature") adj3 (review* or overview*)).ti,ab,kf. or (systemic* adj1 review*).ti,ab,kf. or ((systemati* or literature or database* or data-base*) adj10 search*).ti,ab,kf. or ((structured or comprehensive* or systemic*) adj3 search*).ti,ab,kf. or ((literature adj3 review*) and (search* or database* or data-base*)).ti,ab,kf. or (("data extraction" or "data source*") and "study selection").ti,ab,kf. or ("search strategy" and "selection criteria").ti,ab,kf. or ("data source*" and "data synthesis").ti,ab,kf. or (medline or pubmed or embase or cochrane).ab. or ((critical or rapid) adj2 (review* or overview* or synthes*)).ti. or (((critical* or rapid*) adj3 (review* or overview* or synthes*)) and (search* or database* or data-base*)).ab. or (metasynthes* or meta-synthes*).ti,ab,kf.

736702

7

exp clinical trial/ or randomized controlled trial/ or exp clinical trials as topic/ or randomized controlled trials as topic/ or Random Allocation/ or Double-Blind Method/ or Single-Blind Method/ or (clinical trial, phase i or clinical trial, phase ii or clinical trial, phase iii or clinical trial, phase iv or controlled clinical trial or randomized controlled trial or multicenter study or clinical trial).pt. or random*.ti,ab. or (clinic* adj trial*).tw. or ((singl* or doubl* or treb* or tripl*) adj (blind$3 or mask$3)).tw. or Placebos/ or placebo*.tw.

2708469

8

Epidemiologic studies/ or case control studies/ or exp cohort studies/ or Controlled Before-After Studies/ or Case control.tw. or cohort.tw. or Cohort analy$.tw. or (Follow up adj (study or studies)).tw. or (observational adj (study or studies)).tw. or Longitudinal.tw. or Retrospective*.tw. or prospective*.tw. or consecutive*.tw. or Cross sectional.tw. or Cross-sectional studies/ or historically controlled study/ or interrupted time series analysis/ [Onder exp cohort studies vallen ook longitudinale, prospectieve en retrospectieve studies]

4690661

9

Case-control Studies/ or clinical trial, phase ii/ or clinical trial, phase iii/ or clinical trial, phase iv/ or comparative study/ or control groups/ or controlled before-after studies/ or controlled clinical trial/ or double-blind method/ or historically controlled study/ or matched-pair analysis/ or single-blind method/ or (((control or controlled) adj6 (study or studies or trial)) or (compar* adj (study or studies)) or ((control or controlled) adj1 active) or "open label*" or ((double or two or three or multi or trial) adj (arm or arms)) or (allocat* adj10 (arm or arms)) or placebo* or "sham-control*" or ((single or double or triple or assessor) adj1 (blind* or masked)) or nonrandom* or "non-random*" or "quasi-experiment*" or "parallel group*" or "factorial trial" or "pretest posttest" or (phase adj5 (study or trial)) or (case* adj6 (matched or control*)) or (match* adj6 (pair or pairs or cohort* or control* or group* or healthy or age or sex or gender or patient* or subject* or participant*)) or (propensity adj6 (scor* or match*))).ti,ab,kf. or (confounding adj6 adjust*).ti,ab. or (versus or vs or compar*).ti. or ((exp cohort studies/ or epidemiologic studies/ or multicenter study/ or observational study/ or seroepidemiologic studies/ or (cohort* or 'follow up' or followup or longitudinal* or prospective* or retrospective* or observational* or multicent* or 'multi-cent*' or consecutive*).ti,ab,kf.) and ((group or groups or subgroup* or versus or vs or compar*).ti,ab,kf. or ('odds ratio*' or 'relative odds' or 'risk ratio*' or 'relative risk*' or aor or arr or rrr).ab. or (("OR" or "RR") adj6 CI).ab.))

5657499

10

5 and 6 - SR’s

432

11

(5 and 7) not 10 – RCT’s

856

12

(5 and (8 or 9)) not (10 or 11) – Observationele studies

1660

13

10 or 11 or 12

2948

EMBASE

Ontdubbeld

SR

165

165

RCT

257

257

Observationeel

1103

1099

Totaal

1525

1521

No.

Query

Results

#1

'male infertility'/exp OR 'male fertility'/exp OR (('subfertility'/de OR 'childlessness'/exp) AND 'male'/exp) OR (((male* OR men OR man) NEAR/3 (infertil* OR hypofertil* OR 'fertil*' OR subfertil* OR infecund* OR childless* OR reproduct*)):ti,ab,kw) OR (((spermatogen* OR spermiation OR spermiogen*) NEAR/3 failure):ti,ab,kw) OR ((spermatozoon NEAR/3 (abnormalit* OR anomal*)):ti,ab,kw) OR (((semen OR sperm) NEAR/3 (qualit* OR quantit* OR parameter*)):ti,ab,kw) OR asperm*:ti,ab,kw OR asthenazoosperm*:ti,ab,kw OR asthenosperm*:ti,ab,kw OR asthenozoosperm*:ti,ab,kw OR azoosperm*:ti,ab,kw OR cryptosperm*:ti,ab,kw OR cryptozoosperm*:ti,ab,kw OR hyposperm*:ti,ab,kw OR oligoasthenosperm*:ti,ab,kw OR oligosperm*:ti,ab,kw OR oligozoosperm*:ti,ab,kw OR 'retrograde ejaculat*':ti,ab,kw OR 'sco syndrome*':ti,ab,kw OR 'sertoli cell only syndrome*':ti,ab,kw OR teratozoosperm*:ti,ab,kw OR 'thermosensitive genic male steril*':ti,ab,kw OR globozoosperm*:ti,ab,kw OR macrozoosperm*:ti,ab,kw

111014

#2

'smoking cessation'/exp OR 'alcohol abstinence'/exp OR 'phototherapy'/exp OR 'heat'/exp OR 'sauna'/exp OR 'radiation'/exp OR 'clothing'/exp OR 'underwear'/exp OR 'drug dependence'/exp OR ((('smok*' OR 'tobacco' OR 'cigar*' OR 'drug*' OR 'alcohol*') NEAR/3 ('reduc*' OR 'cessati*' OR 'stop*' OR 'quit*' OR 'giv*' OR 'refrain*' OR 'abstinen*' OR 'behavi*' OR 'habit*')):ti,ab,kw) OR (((alcohol OR amphetamin* OR benzodiazepin* OR cannabis OR cocain* OR drug* OR ethanol OR heroin* OR marijuana OR medication OR medicine OR methamphetamin* OR morphin* OR multidrug* OR narcotic* OR opiate* OR opioid* OR pcp OR phencyclidin* OR polydrug* OR polysubstance* OR substance*) NEAR/3 (abus* OR addict* OR craving* OR depend* OR misus* OR 'mis use' OR 'mis using' OR 'nonmedical use' OR 'non medical use' OR 'use disorder*')):ti,ab,kw) OR alcoholism:ti,ab,kw OR alcoholic*:ti,ab,kw OR aud:ti,ab,kw OR (((drug* OR medication OR medicine*) NEAR/3 (overus* OR overutili*)):ti,ab,kw) OR narcotism:ti,ab,kw OR nmupd:ti,ab,kw OR sud:ti,ab,kw OR suds:ti,ab,kw OR (((problematic OR harmful OR hazardous OR unhealthy) NEAR/3 (alcohol OR drinking OR drinker*)):ti,ab,kw) OR 'light therap*':ti,ab,kw OR 'phototherap*':ti,ab,kw OR heat*:ti,ab,kw OR warmth:ti,ab,kw OR bath*:ti,ab,kw OR sauna:ti,ab,kw OR radiation:ti,ab,kw OR cloth:ti,ab,kw OR undercloth*:ti,ab,kw OR undergarment*:ti,ab,kw OR underwear:ti,ab,kw

2599066

#3

#1 AND #2

5134

#4

#3 AND [2000-2024]/py NOT ('conference abstract'/it OR 'editorial'/it OR 'letter'/it OR 'note'/it) NOT (('animal'/exp OR 'animal experiment'/exp OR 'animal model'/exp OR 'nonhuman'/exp) NOT 'human'/exp)

1921

#5

'meta analysis'/exp OR 'meta analysis (topic)'/exp OR metaanaly*:ti,ab OR 'meta analy*':ti,ab OR metanaly*:ti,ab OR 'systematic review'/de OR 'cochrane database of systematic reviews'/jt OR prisma:ti,ab OR prospero:ti,ab OR (((systemati* OR scoping OR umbrella OR 'structured literature') NEAR/3 (review* OR overview*)):ti,ab) OR ((systemic* NEAR/1 review*):ti,ab) OR (((systemati* OR literature OR database* OR 'data base*') NEAR/10 search*):ti,ab) OR (((structured OR comprehensive* OR systemic*) NEAR/3 search*):ti,ab) OR (((literature NEAR/3 review*):ti,ab) AND (search*:ti,ab OR database*:ti,ab OR 'data base*':ti,ab)) OR (('data extraction':ti,ab OR 'data source*':ti,ab) AND 'study selection':ti,ab) OR ('search strategy':ti,ab AND 'selection criteria':ti,ab) OR ('data source*':ti,ab AND 'data synthesis':ti,ab) OR medline:ab OR pubmed:ab OR embase:ab OR cochrane:ab OR (((critical OR rapid) NEAR/2 (review* OR overview* OR synthes*)):ti) OR ((((critical* OR rapid*) NEAR/3 (review* OR overview* OR synthes*)):ab) AND (search*:ab OR database*:ab OR 'data base*':ab)) OR metasynthes*:ti,ab OR 'meta synthes*':ti,ab

1015572

#6

'clinical trial'/exp OR 'randomization'/exp OR 'single blind procedure'/exp OR 'double blind procedure'/exp OR 'crossover procedure'/exp OR 'placebo'/exp OR 'prospective study'/exp OR rct:ab,ti OR random*:ab,ti OR 'single blind':ab,ti OR 'randomised controlled trial':ab,ti OR 'randomized controlled trial'/exp OR placebo*:ab,ti

4003546

#7

'major clinical study'/de OR 'clinical study'/de OR 'case control study'/de OR 'family study'/de OR 'longitudinal study'/de OR 'retrospective study'/de OR 'prospective study'/de OR 'comparative study'/de OR 'cohort analysis'/de OR ((cohort NEAR/1 (study OR studies)):ab,ti) OR (('case control' NEAR/1 (study OR studies)):ab,ti) OR (('follow up' NEAR/1 (study OR studies)):ab,ti) OR (observational NEAR/1 (study OR studies)) OR ((epidemiologic NEAR/1 (study OR studies)):ab,ti) OR (('cross sectional' NEAR/1 (study OR studies)):ab,ti)

8152930

#9

#4 AND #5 – SR’s

165

#10

#4 AND #6 NOT #9 – RCT’s

257

#11

#4 AND (7 OR #8) NOT (#9 OR #10) – Observationele studies

1103

#12

#9 OR #10 OR #11

1525