Module

Uitkomst raming

Toelichting

Percutane VSD- of ASD-sluiting

Geen financiële gevolgen

Uit de toetsing volgt dat de aanbeveling(en) niet breed toepasbaar zijn (<5.000 patiënten) en zal daarom naar verwachting geen substantiële financiële gevolgen hebben voor de collectieve uitgaven.

No.

Query

Results

#1

'transcatheter closure'/exp OR 'device closure'/exp OR ((transcatheter NEAR/3 closure*):ti,ab,kw) OR ((('post device' OR device) NEAR/3 closure*):ti,ab,kw)

11514

#2

'heart atrium septum defect'/exp OR 'heart ventricle septum defect'/exp OR 'asd':ti,ab,kw OR (((atrial OR atrium OR interatrial) NEAR/2 (septal OR septum) NEAR/2 defect*):ti,ab,kw) OR 'atrial heart shunt':ti,ab,kw OR 'cleft heart atrium':ti,ab,kw OR 'interauricular septal defect':ti,ab,kw OR 'lutembacher syndrome':ti,ab,kw OR 'lutembacher`s syndrome':ti,ab,kw OR 'patent ostium secundum':ti,ab,kw OR 'persistent ostium secundum':ti,ab,kw OR 'secundum atrial defect':ti,ab,kw OR 'trilogy of fallot':ti,ab,kw OR (((ventricle OR ventricular OR interventricular) NEAR/3 (septal OR septum) NEAR/3 defect*):ti,ab,kw) OR 'membranous incomplete septum':ti,ab,kw OR 'ventricular septum perforation':ti,ab,kw

112324

#3

'thrombosis prevention'/exp OR 'anticoagulant agent'/exp OR 'anticoagulation'/exp OR 'anticoagulant therapy'/exp OR thromboprophyla*:ti,ab,kw OR ((thrombo* NEAR/3 (prophylaxis OR prophylactic OR prevention)):ti,ab,kw) OR 'anti coagulant*':ti,ab,kw OR 'anticoagulant*':ti,ab,kw OR 'anticoagulat*':ti,ab,kw OR 'anti coagulat*':ti,ab,kw OR 'antithrombotic*':ti,ab,kw OR 'anti thrombotic*':ti,ab,kw OR 'antithrombocytic*':ti,ab,kw OR 'anti thrombocytic*':ti,ab,kw OR 'antiplatelet agent*':ti,ab,kw OR 'antiplatelet drug*':ti,ab,kw OR 'platelet aggregation inhibitor*':ti,ab,kw OR 'platelet inhibitor*':ti,ab,kw OR 'platelet antagonist*':ti,ab,kw OR 'thrombocyte aggregation inhibiting agent*':ti,ab,kw OR 'thrombocyte aggregation inhibitor*':ti,ab,kw OR 'direct oral anticoagulant agent'/exp OR 'direct oral anticoagulant'/exp OR doac*:ti,ab,kw OR 'apixaban'/exp OR 'apixaban':ti,ab,kw OR 'rivaroxaban'/exp OR 'rivaroxaban':ti,ab,kw OR xarelto:ti,ab,kw OR 'edoxaban'/exp OR 'edoxaban':ti,ab,kw OR 'endoxaban':ti,ab,kw OR 'antivitamin k'/exp OR 'antivitamin k':ti,ab,kw OR 'anti vitamin k':ti,ab,kw OR 'vitamin k antagonist*':ti,ab,kw OR vka:ti,ab,kw OR 'choay':ti,ab,kw OR 'heparin'/exp OR 'low molecular weight heparin'/exp OR 'depolymerized heparin*':ti,ab,kw OR 'low molecular heparin*':ti,ab,kw OR 'low molecular weight heparin*':ti,ab,kw OR 'traxyparin*':ti,ab,kw OR 'unfractionated heparin*':ti,ab,kw OR 'heparin* lmw':ti,ab,kw OR 'lmw heparin*':ti,ab,kw OR lmwh:ti,ab,kw OR 'carbasalate calcium'/exp OR 'alcacyl':ti,ab,kw OR 'calcium carbasalate':ti,ab,kw OR 'carbasalate calcium':ti,ab,kw OR 'acetylsalicylic acid calcium'/exp OR 'acetylsalicylic acid calcium':ti,ab,kw OR 'ascal':ti,ab,kw OR 'calcium acetyl salicylate':ti,ab,kw OR 'calcium acetylsalicylate':ti,ab,kw OR 'disprin':ti,ab,kw OR 'acetylsalicylic acid'/exp OR 'acetyl* salicylic acid':ti,ab,kw OR 'acetylsalicylic acid':ti,ab,kw OR 'aspirin*':ti,ab,kw OR 'lysine acetylsalicylate'/exp OR 'acetylsalicylic acid lysine':ti,ab,kw OR 'aspegic':ti,ab,kw OR 'kardegic':ti,ab,kw OR 'lysine acetyl salicylate':ti,ab,kw OR 'lysine acetylsalicylate':ti,ab,kw OR 'lysine acetylsalicylic acid':ti,ab,kw OR 'clopidogrel'/exp OR 'clopidogrel':ti,ab,kw OR 'pcr 4099':ti,ab,kw OR 'pcr4099':ti,ab,kw OR 'plavix':ti,ab,kw OR 'nadroparin'/exp OR 'fraxiparin*':ti,ab,kw OR 'nadroparin*':ti,ab,kw OR 'tinzaparin'/exp OR 'logiparin':ti,ab,kw OR 'tinzaparin':ti,ab,kw OR 'enoxaparin'/exp OR 'clexane':ti,ab,kw OR 'enoxaparin*':ti,ab,kw OR lovenox:ti,ab,kw OR 'dalteparin'/exp OR 'dalteparin*':ti,ab,kw OR 'acenocoumarol'/exp OR 'acenocoumarol*':ti,ab,kw OR 'acenocumarol*':ti,ab,kw OR sintrom:ti,ab,kw OR 'phenprocoumon'/exp OR 'fenprocoumon':ti,ab,kw OR marcumar:ti,ab,kw OR marcoumar:ti,ab,kw OR phenprocoumarol:ti,ab,kw OR 'phenprocoumon':ti,ab,kw OR 'warfarin'/exp OR coumadin:ti,ab,kw OR 'warfarin*':ti,ab,kw

942668

#4

#1 AND #2 AND #3 NOT ('conference abstract'/it OR 'editorial'/it OR 'letter'/it OR 'note'/it) NOT (('animal'/exp OR 'animal experiment'/exp OR 'animal model'/exp OR 'nonhuman'/exp) NOT 'human'/exp) AND [2014-2024]/py

460

#5

'meta analysis'/exp OR 'meta analysis (topic)'/exp OR metaanaly*:ti,ab OR 'meta analy*':ti,ab OR metanaly*:ti,ab OR 'systematic review'/de OR 'cochrane database of systematic reviews'/jt OR prisma:ti,ab OR prospero:ti,ab OR (((systemati* OR scoping OR umbrella OR 'structured literature') NEAR/3 (review* OR overview*)):ti,ab) OR ((systemic* NEAR/1 review*):ti,ab) OR (((systemati* OR literature OR database* OR 'data base*') NEAR/10 search*):ti,ab) OR (((structured OR comprehensive* OR systemic*) NEAR/3 search*):ti,ab) OR (((literature NEAR/3 review*):ti,ab) AND (search*:ti,ab OR database*:ti,ab OR 'data base*':ti,ab)) OR (('data extraction':ti,ab OR 'data source*':ti,ab) AND 'study selection':ti,ab) OR ('search strategy':ti,ab AND 'selection criteria':ti,ab) OR ('data source*':ti,ab AND 'data synthesis':ti,ab) OR medline:ab OR pubmed:ab OR embase:ab OR cochrane:ab OR (((critical OR rapid) NEAR/2 (review* OR overview* OR synthes*)):ti) OR ((((critical* OR rapid*) NEAR/3 (review* OR overview* OR synthes*)):ab) AND (search*:ab OR database*:ab OR 'data base*':ab)) OR metasynthes*:ti,ab OR 'meta synthes*':ti,ab

1033644

#6

'clinical trial'/exp OR 'randomization'/exp OR 'single blind procedure'/exp OR 'double blind procedure'/exp OR 'crossover procedure'/exp OR 'placebo'/exp OR 'prospective study'/exp OR rct:ab,ti OR random*:ab,ti OR 'single blind':ab,ti OR 'randomised controlled trial':ab,ti OR 'randomized controlled trial'/exp OR placebo*:ab,ti

3973485

#7

'major clinical study'/de OR 'clinical study'/de OR 'case control study'/de OR 'family study'/de OR 'longitudinal study'/de OR 'retrospective study'/de OR 'prospective study'/de OR 'comparative study'/de OR 'cohort analysis'/de OR ((cohort NEAR/1 (study OR studies)):ab,ti) OR (('case control' NEAR/1 (study OR studies)):ab,ti) OR (('follow up' NEAR/1 (study OR studies)):ab,ti) OR (observational NEAR/1 (study OR studies)) OR ((epidemiologic NEAR/1 (study OR studies)):ab,ti) OR (('cross sectional' NEAR/1 (study OR studies)):ab,ti)

8077860

#8

'case control study'/de OR 'comparative study'/exp OR 'control group'/de OR 'controlled study'/de OR 'controlled clinical trial'/de OR 'crossover procedure'/de OR 'double blind procedure'/de OR 'phase 2 clinical trial'/de OR 'phase 3 clinical trial'/de OR 'phase 4 clinical trial'/de OR 'pretest posttest design'/de OR 'pretest posttest control group design'/de OR 'quasi experimental study'/de OR 'single blind procedure'/de OR 'triple blind procedure'/de OR (((control OR controlled) NEAR/6 trial):ti,ab,kw) OR (((control OR controlled) NEAR/6 (study OR studies)):ti,ab,kw) OR (((control OR controlled) NEAR/1 active):ti,ab,kw) OR 'open label*':ti,ab,kw OR (((double OR two OR three OR multi OR trial) NEAR/1 (arm OR arms)):ti,ab,kw) OR ((allocat* NEAR/10 (arm OR arms)):ti,ab,kw) OR placebo*:ti,ab,kw OR 'sham-control*':ti,ab,kw OR (((single OR double OR triple OR assessor) NEAR/1 (blind* OR masked)):ti,ab,kw) OR nonrandom*:ti,ab,kw OR 'non-random*':ti,ab,kw OR 'quasi-experiment*':ti,ab,kw OR crossover:ti,ab,kw OR 'cross over':ti,ab,kw OR 'parallel group*':ti,ab,kw OR 'factorial trial':ti,ab,kw OR ((phase NEAR/5 (study OR trial)):ti,ab,kw) OR ((case* NEAR/6 (matched OR control*)):ti,ab,kw) OR ((match* NEAR/6 (pair OR pairs OR cohort* OR control* OR group* OR healthy OR age OR sex OR gender OR patient* OR subject* OR participant*)):ti,ab,kw) OR ((propensity NEAR/6 (scor* OR match*)):ti,ab,kw) OR versus:ti OR vs:ti OR compar*:ti OR ((compar* NEAR/1 study):ti,ab,kw) OR (('major clinical study'/de OR 'clinical study'/de OR 'cohort analysis'/de OR 'observational study'/de OR 'cross-sectional study'/de OR 'multicenter study'/de OR 'correlational study'/de OR 'follow up'/de OR cohort*:ti,ab,kw OR 'follow up':ti,ab,kw OR followup:ti,ab,kw OR longitudinal*:ti,ab,kw OR prospective*:ti,ab,kw OR retrospective*:ti,ab,kw OR observational*:ti,ab,kw OR 'cross sectional*':ti,ab,kw OR cross?ectional*:ti,ab,kw OR multicent*:ti,ab,kw OR 'multi-cent*':ti,ab,kw OR consecutive*:ti,ab,kw) AND (group:ti,ab,kw OR groups:ti,ab,kw OR subgroup*:ti,ab,kw OR versus:ti,ab,kw OR vs:ti,ab,kw OR compar*:ti,ab,kw OR 'odds ratio*':ab OR 'relative odds':ab OR 'risk ratio*':ab OR 'relative risk*':ab OR 'rate ratio':ab OR aor:ab OR arr:ab OR rrr:ab OR ((('or' OR 'rr') NEAR/6 ci):ab)))

14828124

#9

#4 AND #5 - SR

45

#10

#4 AND #6 NOT #9 - RCT

88

#11

#4 AND (#7 OR #8) NOT (#9 OR #10) - observationeel

155

#12

#9 OR #10 OR #11

288

#

Searches

Results

1

exp Septal Occluder Device/ or (transcatheter adj3 closure*).ti,ab,kf. or (('post device' or device) adj3 closure*).ti,ab,kf.

9044

2

exp Heart Septal Defects, Ventricular/ or exp Heart Septal Defects, Atrial/ or 'asd'.ti,ab,kf. or ((atrial or atrium or interatrial) adj2 (septal or septum) adj2 defect*).ti,ab,kf. or 'atrial heart shunt'.ti,ab,kf. or 'cleft heart atrium'.ti,ab,kf. or 'interauricular septal defect'.ti,ab,kf. or 'lutembacher syndrome'.ti,ab,kf. or 'lutembacher`s syndrome'.ti,ab,kf. or 'patent ostium secundum'.ti,ab,kf. or 'persistent ostium secundum'.ti,ab,kf. or 'secundum atrial defect'.ti,ab,kf. or 'trilogy of fallot'.ti,ab,kf. or ((ventricle or ventricular or interventricular) adj3 (septal or septum) adj3 defect*).ti,ab,kf. or 'membranous incomplete septum'.ti,ab,kf. or 'ventricular septum perforation'.ti,ab,kf.

73786

3

exp Anticoagulants/ or exp Platelet Aggregation Inhibitors/ or thromboprophyla*.ti,ab,kf. or (thrombo* adj3 (prophylaxis or prophylactic or prevention)).ti,ab,kf. or (anti coagulant* or anticoagulant* or anticoagulat* or anti coagulat* or antithrombotic* or anti thrombotic* or antithrombocytic* or anti thrombocytic* or 'antiplatelet agent*' or 'antiplatelet drug*' or 'platelet aggregation inhibitor*' or 'platelet inhibitor*' or platelet antagonist* or 'thrombocyte aggregation inhibiting agent*' or 'thrombocyte aggregation inhibitor*' or doac*).ti,ab,kf. or apixaban'.ti,ab,kf. or exp Rivaroxaban/ or Rivaroxaban.ti,ab,kf. or xarelto.ti,ab,kf. or 'edoxaban'.ti,ab,kf. or 'endoxaban'.ti,ab,kf. or Vitamin K/ai or (antivitamin k or anti vitamin k or vitamin k antagonist* or vka or choay).ti,ab,kf. or exp Heparin/ or exp Heparin, Low-Molecular-Weight/ or (heparin* or traxyparin* or lmwh).ti,ab,kf. or 'alcacyl'.ti,ab,kf. or 'calcium carbasalate'.ti,ab,kf. or 'carbasalate calcium'.ti,ab,kf. or 'acetylsalicylic acid calcium'.ti,ab,kf. or 'ascal'.ti,ab,kf. or 'calcium acetyl salicylate'.ti,ab,kf. or 'calcium acetylsalicylate'.ti,ab,kf. or 'disprin'.ti,ab,kf. or exp Aspirin/ or 'acetyl* salicylic acid'.ti,ab,kf. or 'acetylsalicylic acid'.ti,ab,kf. or 'aspirin*'.ti,ab,kf. or 'acetylsalicylic acid lysine'.ti,ab,kf. or 'aspegic'.ti,ab,kf. or 'kardegic'.ti,ab,kf. or 'lysine acetyl salicylate'.ti,ab,kf. or 'lysine acetylsalicylate'.ti,ab,kf. or 'lysine acetylsalicylic acid'.ti,ab,kf. or exp Clopidogrel/ or 'clopidogrel'.ti,ab,kf. or 'pcr 4099'.ti,ab,kf. or 'pcr4099'.ti,ab,kf. or 'plavix'.ti,ab,kf. or exp Nadroparin/ or 'fraxiparin*'.ti,ab,kf. or 'nadroparin*'.ti,ab,kf. or exp Tinzaparin/ or 'logiparin'.ti,ab,kf. or 'tinzaparin'.ti,ab,kf. or exp Enoxaparin/ or 'clexane'.ti,ab,kf. or 'enoxaparin*'.ti,ab,kf. or lovenox.ti,ab,kf. or exp Dalteparin/ or 'dalteparin*'.ti,ab,kf. or exp Acenocoumarol/ or exp Acenocoumarol/ or 'acenocumarol*'.ti,ab,kf. or sintrom.ti,ab,kf. or exp Phenprocoumon/ or 'fenprocoumon'.ti,ab,kf. or marcumar.ti,ab,kf. or marcoumar.ti,ab,kf. or phenprocoumarol.ti,ab,kf. or 'phenprocoumon'.ti,ab,kf. or exp Warfarin/ or coumadin.ti,ab,kf. or 'warfarin*'.ti,ab,kf.

500897

4

(1 and 2 and 3) not (comment/ or editorial/ or letter/) not ((exp animals/ or exp models, animal/) not humans/)

290

5

limit 4 to yr="2014 -Current"

147

6

meta-analysis/ or meta-analysis as topic/ or (metaanaly* or meta-analy* or metanaly*).ti,ab,kf. or systematic review/ or cochrane.jw. or (prisma or prospero).ti,ab,kf. or ((systemati* or scoping or umbrella or "structured literature") adj3 (review* or overview*)).ti,ab,kf. or (systemic* adj1 review*).ti,ab,kf. or ((systemati* or literature or database* or data-base*) adj10 search*).ti,ab,kf. or ((structured or comprehensive* or systemic*) adj3 search*).ti,ab,kf. or ((literature adj3 review*) and (search* or database* or data-base*)).ti,ab,kf. or (("data extraction" or "data source*") and "study selection").ti,ab,kf. or ("search strategy" and "selection criteria").ti,ab,kf. or ("data source*" and "data synthesis").ti,ab,kf. or (medline or pubmed or embase or cochrane).ab. or ((critical or rapid) adj2 (review* or overview* or synthes*)).ti. or (((critical* or rapid*) adj3 (review* or overview* or synthes*)) and (search* or database* or data-base*)).ab. or (metasynthes* or meta-synthes*).ti,ab,kf.

727827

7

exp clinical trial/ or randomized controlled trial/ or exp clinical trials as topic/ or randomized controlled trials as topic/ or Random Allocation/ or Double-Blind Method/ or Single-Blind Method/ or (clinical trial, phase i or clinical trial, phase ii or clinical trial, phase iii or clinical trial, phase iv or controlled clinical trial or randomized controlled trial or multicenter study or clinical trial).pt. or random*.ti,ab. or (clinic* adj trial*).tw. or ((singl* or doubl* or treb* or tripl*) adj (blind$3 or mask$3)).tw. or Placebos/ or placebo*.tw.

2693408

8

Epidemiologic studies/ or case control studies/ or exp cohort studies/ or Controlled Before-After Studies/ or Case control.tw. or cohort.tw. or Cohort analy$.tw. or (Follow up adj (study or studies)).tw. or (observational adj (study or studies)).tw. or Longitudinal.tw. or Retrospective*.tw. or prospective*.tw. or consecutive*.tw. or Cross sectional.tw. or Cross-sectional studies/ or historically controlled study/ or interrupted time series analysis/ [Onder exp cohort studies vallen ook longitudinale, prospectieve en retrospectieve studies]

4657990

9

Case-control Studies/ or clinical trial, phase ii/ or clinical trial, phase iii/ or clinical trial, phase iv/ or comparative study/ or control groups/ or controlled before-after studies/ or controlled clinical trial/ or double-blind method/ or historically controlled study/ or matched-pair analysis/ or single-blind method/ or (((control or controlled) adj6 (study or studies or trial)) or (compar* adj (study or studies)) or ((control or controlled) adj1 active) or "open label*" or ((double or two or three or multi or trial) adj (arm or arms)) or (allocat* adj10 (arm or arms)) or placebo* or "sham-control*" or ((single or double or triple or assessor) adj1 (blind* or masked)) or nonrandom* or "non-random*" or "quasi-experiment*" or "parallel group*" or "factorial trial" or "pretest posttest" or (phase adj5 (study or trial)) or (case* adj6 (matched or control*)) or (match* adj6 (pair or pairs or cohort* or control* or group* or healthy or age or sex or gender or patient* or subject* or participant*)) or (propensity adj6 (scor* or match*))).ti,ab,kf. or (confounding adj6 adjust*).ti,ab. or (versus or vs or compar*).ti. or ((exp cohort studies/ or epidemiologic studies/ or multicenter study/ or observational study/ or seroepidemiologic studies/ or (cohort* or 'follow up' or followup or longitudinal* or prospective* or retrospective* or observational* or multicent* or 'multi-cent*' or consecutive*).ti,ab,kf.) and ((group or groups or subgroup* or versus or vs or compar*).ti,ab,kf. or ('odds ratio*' or 'relative odds' or 'risk ratio*' or 'relative risk*' or aor or arr or rrr).ab. or (("OR" or "RR") adj6 CI).ab.))

5627546

10

5 and 6 - SR

27

11

(5 and 7) not 10 - RCT

45

12

(5 and (8 or 9)) not (10 or 11) - observationeel

30

13

10 or 11 or 12

102