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Niet epitheliale maligniteiten van het ovarium

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Initiatief: NVOG Aantal modules: 34
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Niet epitheliale maligniteiten van het ovarium - Algemeen

Publicatiedatum: 14-04-2026
Beoordeeld op geldigheid: 14-04-2026

Indeling

De niet-epitheliale tumoren van het ovarium worden als volgt ingedeeld:

 

Kiemceltumoren

De meest gehanteerde classificatie is volgens de WHO 2020 classificatie (en komt grotendeels overeen met die van de kiemceltumoren van de testis):

  • Teratoom (benigne)
  • Immatuur teratoom
  • Dysgerminoom
  • Yolc sac tumor (ook wel dooierzak tumor)
  • Embryonaal carcinoom
  • Choriocarcinoom
  • Gemengde kiemcel tumor
  • Monodermaal teratoom en somatische type tumoren ontstaan uit dermoid cysten:
    • Struma ovarii NOS of maligne
    • Strumaal carcinoid
    • teratoom met maligne transformatie

Kiemcel seks cord stromal cell tumoren

 

  • Gonadoblastoom

            Gemengde kiemcel- seks cord stromal tumor ongeclassificeerd

 

Sex cord-stromaceltumoren

  • Pure sexcordtumor
    • Adulte granulosaceltumor
    • Juveniele granulosaceltumor
    • Sertoliceltumor
    • Sexcordtumor met annular tubules (SCTAT)
  • Puur stromale tumor
    • Fibroom
    • Thecoom/geluteïniseerd thecoom (met scleroserende peritonitis)
    • Sclerosing/microcysteuze/signet-ring stromale tumor
    • Leydigceltumor
    • Steroïdceltumor NOS
    • Fibrosarcoom
  • Gemengde sexcord-stromaceltumoren
    • Sertoli-Leydigceltumor (goed, matig of slecht gedifferentieerd)
    • Retiform
    • Sexcord-stromaceltumor NOS
    • Gynandroblastoom

Mesenchymale tumoren

  • Endometrioid stromal sarcoom (laaggradig, hooggradig))
  • Smooth muscle tumor
    • Leiomyoom
    • Smooth muscle tumor of uncertain malignant potential (STUMP)
    • Leiomyosarcoom

Mixed epithelial and mesenchymale tumoren

            Adenosarcoom

Onderbouwing

  1. 1 - Female Genital Tumours; WHO Classification of Tumours, 5th Edition, Volume 4; WHO Classification of Tumours Editorial Board 2020 Online: IARC Publications Website - Female Genital Tumours
  2. 2 - Abu-Rustum NR, Restivo A, Ivy J, et al. Retroperitoneal nodal metastasis in primary and recurrent granulosa cell tumors of the ovary. Gynecologic Oncology 2006 October;103(1):31-4.
  3. 3 - Baranzelli MC, Bouffet E, Quintana E, et al. Non- seminomatous ovarian germ cell tumours in children. Eur J Cancer 2000;36(3):376-83.
  4. 4 - Brown J, Shvartsman H, Deavers M, et al. The activity of taxanes in the treatment of sex cord-stromal ovarian tumors. J Clin Oncol 2004;22(17):3517-23.
  5. 5 - Brown J, Shvartsman HS, Deavers MT, et al. The activity of taxanes compared with bleomycin, etoposide, and cisplatin in the treatment of sex cord-stromal ovarian tumors. Gynecol Oncol. 2005;97(2):489-96.
  6. 6 - Brown J, Sood AK, Deavers MT, et al. Patterns of metastasis in sex cord-stromal tumors of the ovary: Can routine staging lymphadenectomy be omitted? Gynecol Oncol 2009 April;113(1):86-90.
  7. 7 - Brown J, Friedlander M, Backes F et al. Gynecologic Cancer Intergroup (GCIG) Consensus Review for Ovarian Germ Cell Tumors. International Journal of Gynecological Cancer 2014;24(9):48–54.
  8. 8 - Cushing B, Giller R, Ablin A, et al. Surgical resection alone is effective treatment for ovarian immature teratoma in children and adolescents: a report of the pediatric oncology group and the children's cancer group. Am J Obstet Gynecol 1999;181(2):353-8.
  9. 9 - Dark G, Bower M, Newlands E, et al. Surveillance policy for stage I ovarian germ cell tumors. J Clin Oncol 1997;15(2):620-4.
  10. 10 - Gershenson DM. Current advances in the management of malignant germ cell and sex cordstromal tumors of the ovary. Gynecol Oncol 2012 June;125(3):515-7.
  11. 12 - Gurumurthy M, Bryant A, Shanbhag S. Effectiveness of different treatment modalities for the management of adult-onset granulosa cell tumours of the ovary (primary and recurrent). Cochrane Database Syst Rev. 2014 Apr 21;4:CD006912. doi: 10.1002/14651858.CD006912.pub2.
  12. 13 - Hardy R, Bell J, Nicely C, et al. Hormonal treatment of a recurrent granulosa cell tumor of the ovary: case report and review of the literature. Gynecol Oncol 2005;96(3):865-9.
  13. 14 - Kleppe M, Amkreutz LCM, Van Gorp T, et al. Lymph-node metastasis in stage I and II sex cord stromal and malignant germ cell tumours of the ovary. Gynaecologic Oncology 133;1; april 2014; p 124-127.
  14. 15 - Korach J, Perri T, Beiner M, et al. Promising effect of aromatase inhibitors on recurrent granulosa cell tumors. Int J Gynecol Cancer 2009;19(5):830-3.
  15. 16 - Mangili G, Scarfone G, Gadducci A, et al. Is adjuvant chemotherapy indicated in stage I pure immature ovarian teratoma (IT)? A multicentre Italian trial in ovarian cancer (MITO-9). Gynecol Oncol 2010;119:48-52.
  16. 17 - Mom C, Engelen M, Willemse P, et al. Granulosa cell tumors of the ovary: the clinical value of serum inhibin A and B levels in a large single center cohort. Gynecol Oncol 2007;105(2):365-72.
  17. 18 - Murugaesu N, Schmid P, Dancey G, et al. Malignant ovarian germ cell tumors: identification of novel prognostic markers and long-term outcome after multimodality treatment. J Clin Oncol. 2006;24(30):4862.
  18. 19 - Powell J, Connor G, Henderson G. Management of recurrent juvenile granulosa cell tumor of the ovary. Gynecol Oncol 2001;81(1):113-6.
  19. 20 - Sommeijer DW, Sjoquist KM, Friedlander M. Hormonal treatment in recurrent and metastatic gynaecological cancers: a review of the current literature. Curr Oncol Rep 2013 Dec; 15(6):541-548.
  20. 21 - Tao X, Sood A, Deavers M, et al. Anti-angiogenesis therapy with bevacizumab for patients with ovarian granulosa cell tumors. Gynecol Oncol 2009;114(3):431-6.
  21. 22 - Thrall MM, Paley P, Pizer E, et al. Patterns of spread and recurrence of sex cordstromal tumors of the ovary. Gynecol Oncol 2011 August;122(2):242-5.
  22. 23 - Van Meurs HS, Bleeker MC, van der Velden J et al. The incidence of endometrial hyperplasia and cancer in 1031 patients with a granulosa cell tumor of the ovary: long-term follow-up in a population-based cohort study. Int J Gynecol Cancer. 2013 Oct;23(8):1417-22.
  23. 24 - Van Meurs HS, Buist MR, Westermann AM et al. Effectiveness of chemotherapy in measurable granulosa cell tumors: a retrospective study and review of literature. Int J Gynecol Cancer. 2014a Mar;24(3):496-505.
  24. 25 - Van Meurs HS, van Lonkhuijzen LR, Limpens J, et al. Hormone therapy in ovarian granulosa cell tumors: a systematic review. Gynecol Oncol. 2014b Jul;134(1):196-205.
  25. 26 - Wolf JK1, Mullen J, Eifel PJ, et al. Radiation treatment of advanced or recurrent granulosa cell tumor of the ovary. Gynecol Oncol. 1999 Apr;73(1):35-41.
  26. 27 - WHO Classification of Tumors of Female Reproductive Organs, edited by R.J. Kurman, M.L. Carcangiu, S. Herrington, R.H. Young; IARC, Lyon 2014.

Beoordelingsdatum en geldigheid

Publicatiedatum  : 14-04-2026

Beoordeeld op geldigheid  : 14-04-2026

Initiatief en autorisatie

Initiatief:
  • Nederlandse Vereniging voor Obstetrie en Gynaecologie
Geautoriseerd door:
  • Nederlandse Vereniging voor Obstetrie en Gynaecologie
Volgende:
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