De NVvH is als houder van deze richtlijn de eerstverantwoordelijke voor de actualiteit van deze richtlijn. De andere aan deze richtlijn deelnemende wetenschappelijk verenigingen of gebruikers van de richtlijn delen de verantwoordelijkheid en informeren de eerstverantwoordelijke over relevante ontwikkelingen binnen hun vakgebied.

De eerste herziening van de richtlijn: onderzoek en behandeling van galstenen is ontwikkeld onder auspiciën van de commissie kwaliteit van de Nederlandse Vereniging voor Heelkunde, in samenwerking met de Orde van Medisch Specialisten.

Doel

De richtlijn beoogt een rationale in het beleid van patiënten met galstenen bereikt te hebben door gebruik te maken van het beste voorhanden bewijs in de literatuur.

Doelgroep

Chirurgen, maag-darm leverartsen en radiologen.

Voor het ontwikkelen van de richtlijn is in 2014 een multidisciplinaire werkgroep ingesteld, bestaande uit vertegenwoordigers van alle relevante specialismen die betrokken zijn bij de zorg voor patiënten met galstenen te maken hebben (zie hiervoor de samenstelling van de werkgroep).

De werkgroepleden zijn door hun beroepsverenigingen gemandateerd voor deelname. De werkgroep werkte gedurende een jaar aan de totstandkoming van de richtlijn.

De werkgroep is verantwoordelijk voor de integrale tekst van deze richtlijn.

• Drs E de Boer
• Dr D Boerma
• Dr KJ van Erpecum
• Dr Ir JJ Hermans
• Drs MP Lamberts
• Dr EAJ Rauws
• Dr JMJ Schreinemakers
• Prof Dr CJHM van Laarhoven MSc, voorzitter

De richtlijn beoogt een rationale in het beleid van patiënten met galstenen bereikt te hebben door gebruik te maken van het beste voorhanden bewijs in de literatuur. Hiertoe zijn strikte ‘Evidence Based Medicine’ technieken gebruikt zoals terug te lezen in de “ter verantwoording” (Appendix A). Gebruik werd gemaakt van korte klinische vraagstellingen met antwoorden gebaseerd op literatuur die gerangschikt is op ‘level of evidence’. Hieraan werden aanbevelingen verbonden die eveneens ingedeeld zijn naar niveau. Van alle gebruikte literatuur werden, geordend naar hoofdstuk en vraagstelling, in bewijsklasse tabellen de studie karakteristieken en belangrijkste uitkomstmaten gepresenteerd als naslag. De richtlijn werd getoetst en becommentarieerd door een landelijk panel van experts.

De commissie heeft gezamenlijk een aantal vragen over galsteenlijden geformuleerd. Aan de hand van deze vragen zijn zoekstrategieën opgesteld, gebruikmakend van vrije tekst woorden met synoniemen en MeSH-termen. Er werd gezocht in Pubmed. De zoekvragen in Pubmed werden elke maand automatisch herhaald zodat nieuwe artikelen tot en met oktober 2014 zijn gebruikt. Als de zoekvraag meer dan duizend titels opleverde, werd de vraag versmald. De selectie op titelniveau werd verricht door 1 persoon. De geselecteerde titels werden vanuit de verschillende databases getransporteerd naar Endnote. Na verwijdering van dubbele titels bleef een database van 1560 artikelen over. Van deze artikelen zijn de abstracts beoordeeld door dezelfde persoon. Selectie werd bepaald door de kwaliteit van de aanwezige literatuur (level of evidence). Bij twijfel werd het betreffende artikel geselecteerd. Vervolgens werden de geselecteerde artikelen per onderwerp beoordeeld op level of evidence in groepen van 3 commissieleden. Bij de geselecteerde artikelen werden de referenties nagekeken.

Asymptomatische galstenen

(("gallstones"[MeSH Terms] OR "gallstones"[All Fields] OR "cholelithiasis"[MeSH Terms] OR "cholelithiasis"[All Fields]) OR ("cholelithiasis"[MeSH Terms] OR "cholelithiasis"[All Fields]) OR ("cholecystolithiasis"[MeSH Terms] OR "cholecystolithiasis"[All Fields]) OR ("choledocholithiasis"[MeSH Terms] OR "choledocholithiasis"[All Fields])) AND (asymptomatic[All Fields] OR silent[All Fields])

Recurrence

((((("common bile duct"[MeSH Terms] OR ("common"[All Fields] AND "bile"[All Fields] AND "duct"[All Fields]) OR "common bile duct"[All Fields]) OR biliary[All Fields]) AND (("calculi"[MeSH Terms] OR "calculi"[All Fields] OR "stone"[All Fields]) OR ("calculi"[MeSH Terms] OR "calculi"[All Fields]))) OR ("choledocholithiasis"[MeSH Terms] OR "choledocholithiasis"[All Fields])) AND ("recurrence"[MeSH Terms] OR "recurrence"[All Fields]) AND ("cholecystectomy"[MeSH Terms] OR "cholecystectomy"[All Fields])) AND ((clinical[Title/Abstract] AND trial[Title/Abstract]) OR "clinical trials as topic"[MeSH Terms] OR clinical trial[Publication Type] OR (random[Title/Abstract] OR random/aleatory[Title/Abstract] OR random/aligned[Title/Abstract] OR random/and[Title/Abstract] OR random/arm[Title/Abstract] OR random/basal[Title/Abstract] OR random/blind[Title/Abstract] OR random/block[Title/Abstract] OR random/blocked[Title/Abstract] OR random/cdp[Title/Abstract] OR random/clustered[Title/Abstract] OR random/combinatorial[Title/Abstract] OR random/double[Title/Abstract] OR random/ethanol[Title/Abstract] OR random/extended[Title/Abstract] OR random/fixed[Title/Abstract] OR random/half[Title/Abstract] OR random/irrelevant[Title/Abstract] OR random/linkage[Title/Abstract] OR random/matched[Title/Abstract] OR random/mixed[Title/Abstract] OR random/nonrandom[Title/Abstract] OR random/orthogonal[Title/Abstract] OR random/random[Title/Abstract] OR random/representative[Title/Abstract] OR random/systematic[Title/Abstract] OR random/turns[Title/Abstract] OR random'[Title/Abstract] OR random1[Title/Abstract] OR random1y[Title/Abstract] OR randomally[Title/Abstract] OR randomaly[Title/Abstract] OR randomamplified[Title/Abstract] OR randoman[Title/Abstract] OR randomand[Title/Abstract] OR randomate[Title/Abstract] OR randombalance[Title/Abstract] OR randombred[Title/Abstract] OR randombreds[Title/Abstract] OR randomcoil[Title/Abstract] OR randomdigit[Title/Abstract] OR randomdot[Title/Abstract] OR randome[Title/Abstract] OR randomed[Title/Abstract] OR randomeffects[Title/Abstract] OR randomely[Title/Abstract] OR randomer[Title/Abstract] OR randomezed[Title/Abstract] OR randomforest[Title/Abstract] OR randomfrog[Title/Abstract] OR randomi[Title/Abstract] OR randomiazed[Title/Abstract] OR randomic[Title/Abstract] OR randomically[Title/Abstract] OR randomicaly[Title/Abstract] OR randomiced[Title/Abstract] OR randomicity[Title/Abstract] OR randomied[Title/Abstract] OR randomifzed[Title/Abstract] OR randomil[Title/Abstract] OR randomily[Title/Abstract] OR randomin[Title/Abstract] OR randomined[Title/Abstract] OR randomingly[Title/Abstract] OR randominization[Title/Abstract] OR randominzed[Title/Abstract] OR randomirrespective[Title/Abstract] OR randomis[Title/Abstract] OR randomisation[Title/Abstract] OR randomisation'[Title/Abstract] OR randomisations[Title/Abstract] OR randomisationsecondary[Title/Abstract] OR randomisd[Title/Abstract] OR randomise[Title/Abstract] OR randomised[Title/Abstract] OR randomised/controlled[Title/Abstract] OR randomised/crossover[Title/Abstract] OR randomised/eligible[Title/Abstract] OR randomised/observational[Title/Abstract] OR randomised'[Title/Abstract] OR randomisedrandomised[Title/Abstract] OR randomisee[Title/Abstract] OR randomisees[Title/Abstract] OR randomisely[Title/Abstract] OR randomises[Title/Abstract] OR randomisiert[Title/Abstract] OR randomisierte[Title/Abstract] OR randomisierung[Title/Abstract] OR randomising[Title/Abstract] OR randomisly[Title/Abstract] OR randomiz[Title/Abstract] OR randomizable[Title/Abstract] OR randomizadely[Title/Abstract] OR randomizado[Title/Abstract] OR randomizaion[Title/Abstract] OR randomization[Title/Abstract] OR randomization/allocation[Title/Abstract] OR randomization/baseline[Title/Abstract] OR randomization/blinding[Title/Abstract] OR randomization/diversification[Title/Abstract] OR randomization/matching[Title/Abstract] OR randomization/nonspecificity[Title/Abstract] OR randomization/permutation[Title/Abstract] OR randomization/registration[Title/Abstract] OR randomization/selection[Title/Abstract] OR randomization/stabilization[Title/Abstract] OR randomization/start[Title/Abstract] OR randomization'[Title/Abstract] OR randomizationin[Title/Abstract] OR randomizations[Title/Abstract] OR randomizationstudies[Title/Abstract] OR randomizd[Title/Abstract] OR randomize[Title/Abstract] OR randomized[Title/Abstract] OR randomized/15[Title/Abstract] OR randomized/455[Title/Abstract] OR randomized/58[Title/Abstract] OR randomized/blind[Title/Abstract] OR randomized/blinded[Title/Abstract] OR randomized/controlled[Title/Abstract] OR randomized/counterbalanced[Title/Abstract] OR randomized/nonrandomized[Title/Abstract] OR randomized/organized[Title/Abstract] OR randomized/prospective[Title/Abstract] OR randomized/quasirandomized[Title/Abstract] OR randomized/randomized[Title/Abstract] OR randomized/registry[Title/Abstract] OR randomized/screened[Title/Abstract] OR randomized/stratified[Title/Abstract] OR randomized'[Title/Abstract] OR randomized150[Title/Abstract] OR randomizedcrossover[Title/Abstract] OR randomizedduring[Title/Abstract] OR randomizedly[Title/Abstract] OR randomizedphase[Title/Abstract] OR randomizedto[Title/Abstract] OR randomizedtrial[Title/Abstract] OR randomizely[Title/Abstract] OR randomizer[Title/Abstract] OR randomizer'[Title/Abstract] OR randomizes[Title/Abstract] OR randomizied[Title/Abstract] OR randomizing[Title/Abstract] OR randomizing'[Title/Abstract] OR randomizingly[Title/Abstract] OR randomizzati[Title/Abstract] OR randomjungle[Title/Abstract] OR randoml[Title/Abstract] OR randomlike[Title/Abstract] OR randomlly[Title/Abstract] OR randomly[Title/Abstract] OR randomly/linearly[Title/Abstract] OR randomly'[Title/Abstract] OR randomlyassigned[Title/Abstract] OR randomlyselected[Title/Abstract] OR randomlyuniformly[Title/Abstract] OR randommess[Title/Abstract] OR randommethacrylic[Title/Abstract] OR randommized[Title/Abstract] OR randommobility[Title/Abstract] OR randomnes[Title/Abstract] OR randomness[Title/Abstract] OR randomness'[Title/Abstract] OR randomnesses[Title/Abstract] OR randomnicity[Title/Abstract] OR randomnized[Title/Abstract] OR randomnly[Title/Abstract] OR randomomized[Title/Abstract] OR randompf[Title/Abstract] OR randompod[Title/Abstract] OR randompower[Title/Abstract] OR randoms[Title/Abstract] OR randoms'[Title/Abstract] OR randomsample[Title/Abstract] OR randomsed[Title/Abstract] OR randomsource[Title/Abstract] OR randomwalk[Title/Abstract] OR randomwalker[Title/Abstract] OR randomwalksat[Title/Abstract] OR randomy[Title/Abstract] OR randomyl[Title/Abstract] OR randomyly[Title/Abstract] OR randomzed[Title/Abstract] OR randomzied[Title/Abstract] OR randomzing[Title/Abstract]) OR "random allocation"[MeSH Terms] OR "therapeutic use"[Subheading])

Cholelithiasis en comorbiditeit

(("gallstones"[MeSH Terms] OR "gallstones"[All Fields] OR "cholelithiasis"[MeSH Terms] OR "cholelithiasis"[All Fields]) OR ("cholelithiasis"[MeSH Terms] OR "cholelithiasis"[All Fields]) OR ("cholecystolithiasis"[MeSH Terms] OR "cholecystolithiasis"[All Fields]) OR ("choledocholithiasis"[MeSH Terms] OR "choledocholithiasis"[All Fields])) AND (("child"[MeSH Terms] OR "child"[All Fields]) OR ("anemia, sickle cell"[MeSH Terms] OR ("anemia"[All Fields] AND "sickle"[All Fields] AND "cell"[All Fields]) OR "sickle cell anemia"[All Fields] OR ("sickle"[All Fields] AND "cell"[All Fields] AND "disease"[All Fields]) OR "sickle cell disease"[All Fields]) OR ("sickle cell anaemia"[All Fields] OR "anemia, sickle cell"[MeSH Terms] OR ("anemia"[All Fields] AND "sickle"[All Fields] AND "cell"[All Fields]) OR "sickle cell anemia"[All Fields] OR ("sickle"[All Fields] AND "cell"[All Fields] AND "anemia"[All Fields])) OR (sclerosing[All Fields] AND ("cholangitis"[MeSH Terms] OR "cholangitis"[All Fields])) OR ("obesity"[MeSH Terms] OR "obesity"[All Fields]) OR (bariatri[All Fields] OR bariatriac[All Fields] OR bariatric[All Fields] OR bariatric/gi[All Fields] OR bariatric/metabolic[All Fields] OR bariatric'[All Fields] OR bariatric''[All Fields] OR bariatrica[All Fields] OR bariatrically[All Fields] OR bariatricas[All Fields] OR bariatriccenter[All Fields] OR bariatrician[All Fields] OR bariatricians[All Fields] OR bariatricka[All Fields] OR bariatricke[All Fields] OR bariatricko[All Fields] OR bariatrickou[All Fields] OR bariatrico[All Fields] OR bariatricrehab[All Fields] OR bariatrics[All Fields] OR bariatrics/economics[All Fields] OR bariatrics/ethics[All Fields] OR bariatrics/instrumentation[All Fields] OR bariatrics/methods[All Fields] OR bariatrics/nursing[All Fields] OR bariatrics/psychology[All Fields] OR bariatrics/standards[All Fields] OR bariatrics/trends[All Fields] OR bariatricsurgery[All Fields] OR bariatrie[All Fields] OR bariatrique[All Fields] OR bariatrisch[All Fields] OR bariatrische[All Fields] OR bariatrischem[All Fields] OR bariatrischen[All Fields] OR bariatrischer[All Fields] OR bariatrisk[All Fields] OR bariatry[All Fields] OR bariatrycznej[All Fields] OR bariatrycznych[All Fields]) OR ("diabetes mellitus"[MeSH Terms] OR ("diabetes"[All Fields] AND "mellitus"[All Fields]) OR "diabetes mellitus"[All Fields] OR "diabetes"[All Fields] OR "diabetes insipidus"[MeSH Terms] OR ("diabetes"[All Fields] AND "insipidus"[All Fields]) OR "diabetes insipidus"[All Fields]) OR ("thoracic surgical procedures"[MeSH Terms] OR ("thoracic"[All Fields] AND "surgical"[All Fields] AND "procedures"[All Fields]) OR "thoracic surgical procedures"[All Fields] OR ("thoracic"[All Fields] AND "surgery"[All Fields]) OR "thoracic surgery"[All Fields] OR "thoracic surgery"[MeSH Terms] OR ("thoracic"[All Fields] AND "surgery"[All Fields])) OR ("thoracic surgery"[MeSH Terms] OR ("thoracic"[All Fields] AND "surgery"[All Fields]) OR "thoracic surgery"[All Fields] OR ("cardiac"[All Fields] AND "surgery"[All Fields]) OR "cardiac surgery"[All Fields] OR "cardiac surgical procedures"[MeSH Terms] OR ("cardiac"[All Fields] AND "surgical"[All Fields] AND "procedures"[All Fields]) OR "cardiac surgical procedures"[All Fields] OR ("cardiac"[All Fields] AND "surgery"[All Fields]))) AND "humans"[MeSH Terms]

Cholelithiasis en criteria

(("gallstones"[MeSH Terms] OR "gallstones"[All Fields] OR "gallstone"[All Fields]) OR ("cholelithiasis"[MeSH Terms] OR "cholelithiasis"[All Fields]) OR ("cholecystolithiasis"[MeSH Terms] OR "cholecystolithiasis"[All Fields]) OR ("choledocholithiasis"[MeSH Terms] OR "choledocholithiasis"[All Fields])) AND (("diagnosis"[Subheading] OR "diagnosis"[All Fields] OR "symptoms"[All Fields] OR "diagnosis"[MeSH Terms] OR "symptoms"[All Fields]) OR complaints[All Fields]) AND (("standards"[Subheading] OR "standards"[All Fields] OR "criteria"[All Fields]) OR definition[All Fields] OR ("consensus"[MeSH Terms] OR "consensus"[All Fields]))

Choledocholithiasis en cholangiografie

((((("common bile duct"[MeSH Terms] OR ("common"[All Fields] AND "bile"[All Fields] AND "duct"[All Fields]) OR "common bile duct"[All Fields]) OR biliary[All Fields]) AND (("calculi"[MeSH Terms] OR "calculi"[All Fields] OR "stone"[All Fields]) OR ("calculi"[MeSH Terms] OR "calculi"[All Fields]))) OR ("choledocholithiasis"[MeSH Terms] OR "choledocholithiasis"[All Fields])) AND (intra-operative[All Fields] OR intraoperative[All Fields] OR operative[All Fields]) AND ("cholangiography"[MeSH Terms] OR "cholangiography"[All Fields])) AND ((sensitiv[Title/Abstract] OR sensitiva[Title/Abstract] OR sensitivation[Title/Abstract] OR sensitivdty[Title/Abstract] OR sensitive[Title/Abstract] OR sensitive/'bbl[Title/Abstract] OR sensitive/'r123[Title/Abstract] OR sensitive/80[Title/Abstract] OR sensitive/82[Title/Abstract] OR sensitive/accurate[Title/Abstract] OR sensitive/affordable[Title/Abstract] OR sensitive/allergic[Title/Abstract] OR sensitive/alpha[Title/Abstract] OR sensitive/atypical[Title/Abstract] OR sensitive/avirulent[Title/Abstract] OR sensitive/aware[Title/Abstract] OR sensitive/bafilomycin[Title/Abstract] OR sensitive/bbl[Title/Abstract] OR sensitive/ca[Title/Abstract] OR sensitive/cei[Title/Abstract] OR sensitive/competent[Title/Abstract] OR sensitive/conformational[Title/Abstract] OR sensitive/critical[Title/Abstract] OR sensitive/dependent[Title/Abstract] OR sensitive/drug[Title/Abstract] OR sensitive/efficient[Title/Abstract] OR sensitive/estrogen[Title/Abstract] OR sensitive/feca[Title/Abstract] OR sensitive/foscarnet[Title/Abstract] OR sensitive/galanin[Title/Abstract] OR sensitive/gus[Title/Abstract] OR sensitive/hypersensitive/allergic[Title/Abstract] OR sensitive/ifenprodil[Title/Abstract] OR sensitive/insensitive[Title/Abstract] OR sensitive/intermediate[Title/Abstract] OR sensitive/intolerant[Title/Abstract] OR sensitive/isolated[Title/Abstract] OR sensitive/jr[Title/Abstract] OR sensitive/killer[Title/Abstract] OR sensitive/less[Title/Abstract] OR sensitive/magnesium[Title/Abstract] OR sensitive/mannose[Title/Abstract] OR sensitive/mcwi[Title/Abstract] OR sensitive/mdr[Title/Abstract] OR sensitive/more[Title/Abstract] OR sensitive/motor[Title/Abstract] OR sensitive/naive[Title/Abstract] OR sensitive/neutral[Title/Abstract] OR sensitive/normoglycemic[Title/Abstract] OR sensitive/organic[Title/Abstract] OR sensitive/perceptive[Title/Abstract] OR sensitive/ph[Title/Abstract] OR sensitive/phospholipase[Title/Abstract] OR sensitive/platinum[Title/Abstract] OR sensitive/r123[Title/Abstract] OR sensitive/rapp[Title/Abstract] OR sensitive/reactive[Title/Abstract] OR sensitive/recording[Title/Abstract] OR sensitive/reference[Title/Abstract] OR sensitive/reliable[Title/Abstract] OR sensitive/resistance[Title/Abstract] OR sensitive/resistant[Title/Abstract] OR sensitive/responsive[Title/Abstract] OR sensitive/robust[Title/Abstract] OR sensitive/s[Title/Abstract] OR sensitive/selective[Title/Abstract] OR sensitive/sensitive[Title/Abstract] OR sensitive/simple[Title/Abstract] OR sensitive/specific[Title/Abstract] OR sensitive/stable[Title/Abstract] OR sensitive/sterol[Title/Abstract] OR sensitive/supportive[Title/Abstract] OR sensitive/tan[Title/Abstract] OR sensitive/tartar[Title/Abstract] OR sensitive/temperature[Title/Abstract] OR sensitive/tolerant[Title/Abstract] OR sensitive/total[Title/Abstract] OR sensitive/untreated[Title/Abstract] OR sensitive/voltage[Title/Abstract] OR sensitive'[Title/Abstract] OR sensitive'/'atypical[Title/Abstract] OR sensitive''[Title/Abstract] OR sensitive's[Title/Abstract] OR sensitive1[Title/Abstract] OR sensitive2[Title/Abstract] OR sensitive2/weak[Title/Abstract] OR sensitive23[Title/Abstract] OR sensitive3[Title/Abstract] OR sensitive3a[Title/Abstract] OR sensitive4[Title/Abstract] OR sensitive5[Title/Abstract] OR sensitive51[Title/Abstract] OR sensitive52[Title/Abstract] OR sensitive81[Title/Abstract] OR sensitivebiochemical[Title/Abstract] OR sensitivebut[Title/Abstract] OR sensitived[Title/Abstract] OR sensitivehsd[Title/Abstract] OR sensitively[Title/Abstract] OR sensitively/effectively[Title/Abstract] OR sensitivem[Title/Abstract] OR sensitivemutants[Title/Abstract] OR sensitivemutations[Title/Abstract] OR sensitivend[Title/Abstract] OR sensitiveness[Title/Abstract] OR sensitiveness/resistance[Title/Abstract] OR sensitiver[Title/Abstract] OR sensitives[Title/Abstract] OR sensitives'[Title/Abstract] OR sensitivesensorial[Title/Abstract] OR sensitiveslow[Title/Abstract] OR sensitivetest[Title/Abstract] OR sensitiveto[Title/Abstract] OR sensitivetoolsforevaluating[Title/Abstract] OR sensitivety[Title/Abstract] OR sensitivie[Title/Abstract] OR sensitivies[Title/Abstract] OR sensitiviity[Title/Abstract] OR sensitivily[Title/Abstract] OR sensitiviness[Title/Abstract] OR sensitiving[Title/Abstract] OR sensitivit[Title/Abstract] OR sensitivita[Title/Abstract] OR sensitivitat[Title/Abstract] OR sensitivite[Title/Abstract] OR sensitivites[Title/Abstract] OR sensitivities[Title/Abstract] OR sensitivities/allergies[Title/Abstract] OR sensitivities/idiopathic[Title/Abstract] OR sensitivities/insensitivities[Title/Abstract] OR sensitivities/predictive[Title/Abstract] OR sensitivities/sex[Title/Abstract] OR sensitivities/specificities[Title/Abstract] OR sensitivities/specificities/accuracies[Title/Abstract] OR sensitivities/specificities/predictive[Title/Abstract] OR sensitivities'[Title/Abstract] OR sensitivitiness[Title/Abstract] OR sensitivitites[Title/Abstract] OR sensitivitities[Title/Abstract] OR sensitivitity[Title/Abstract] OR sensitivitive[Title/Abstract] OR sensitivitives[Title/Abstract] OR sensitivitiy[Title/Abstract] OR sensitivitty[Title/Abstract] OR sensitivitv[Title/Abstract] OR sensitivity[Title/Abstract] OR sensitivity/1[Title/Abstract] OR sensitivity/100[Title/Abstract] OR sensitivity/26[Title/Abstract] OR sensitivity/58[Title/Abstract] OR sensitivity/67[Title/Abstract] OR sensitivity/68[Title/Abstract] OR sensitivity/76[Title/Abstract] OR sensitivity/85[Title/Abstract] OR sensitivity/90[Title/Abstract] OR sensitivity/92[Title/Abstract] OR sensitivity/93[Title/Abstract] OR sensitivity/94[Title/Abstract] OR sensitivity/97[Title/Abstract] OR sensitivity/acceptability[Title/Abstract] OR sensitivity/accuracy[Title/Abstract] OR sensitivity/accuracy/precision[Title/Abstract] OR sensitivity/action[Title/Abstract] OR sensitivity/affection[Title/Abstract] OR sensitivity/affinity[Title/Abstract] OR sensitivity/allergy[Title/Abstract] OR sensitivity/apoptosis[Title/Abstract] OR sensitivity/attachment[Title/Abstract] OR sensitivity/awareness[Title/Abstract] OR sensitivity/behavioral[Title/Abstract] OR sensitivity/biosynthesis[Title/Abstract] OR sensitivity/blockade[Title/Abstract] OR sensitivity/capacity[Title/Abstract] OR sensitivity/cell[Title/Abstract] OR sensitivity/centre[Title/Abstract] OR sensitivity/certainty[Title/Abstract] OR sensitivity/change[Title/Abstract] OR sensitivity/child[Title/Abstract] OR sensitivity/chromatin[Title/Abstract] OR sensitivity/chronic[Title/Abstract] OR sensitivity/compassion[Title/Abstract] OR sensitivity/competence[Title/Abstract] OR sensitivity/competency[Title/Abstract] OR sensitivity/cooperativity[Title/Abstract] OR sensitivity/delayed[Title/Abstract] OR sensitivity/density[Title/Abstract] OR sensitivity/detectability[Title/Abstract] OR sensitivity/diagnosticity[Title/Abstract] OR sensitivity/dr[Title/Abstract] OR sensitivity/drive[Title/Abstract] OR sensitivity/duration[Title/Abstract] OR sensitivity/dynamic[Title/Abstract] OR sensitivity/ec50[Title/Abstract] OR sensitivity/effect[Title/Abstract] OR sensitivity/elasticity[Title/Abstract] OR sensitivity/emotionality[Title/Abstract] OR sensitivity/error[Title/Abstract] OR sensitivity/expression[Title/Abstract] OR sensitivity/feasibility[Title/Abstract] OR sensitivity/film[Title/Abstract] OR sensitivity/fluorescence[Title/Abstract] OR sensitivity/food[Title/Abstract] OR sensitivity/generation[Title/Abstract] OR sensitivity/glucose[Title/Abstract] OR sensitivity/h[Title/Abstract] OR sensitivity/high[Title/Abstract] OR sensitivity/hostility[Title/Abstract] OR sensitivity/hypersensitive[Title/Abstract] OR sensitivity/idiopathic[Title/Abstract] OR sensitivity/input[Title/Abstract] OR sensitivity/insensitivity[Title/Abstract] OR sensitivity/insulin[Title/Abstract] OR sensitivity/intolerance[Title/Abstract] OR sensitivity/ip[Title/Abstract] OR sensitivity/irlen[Title/Abstract] OR sensitivity/irritation[Title/Abstract] OR sensitivity/isolation[Title/Abstract] OR sensitivity/line[Title/Abstract] OR sensitivity/linewidth[Title/Abstract] OR sensitivity/long[Title/Abstract] OR sensitivity/low[Title/Abstract] OR sensitivity/mean[Title/Abstract] OR sensitivity/negative[Title/Abstract] OR sensitivity/neurology[Title/Abstract] OR sensitivity/noise[Title/Abstract] OR sensitivity/normalcy[Title/Abstract] OR sensitivity/npv[Title/Abstract] OR sensitivity/pain[Title/Abstract] OR sensitivity/partial[Title/Abstract] OR sensitivity/patient[Title/Abstract] OR sensitivity/patterns[Title/Abstract] OR sensitivity/positive[Title/Abstract] OR sensitivity/ppv[Title/Abstract] OR sensitivity/ppv/npv/accuracy[Title/Abstract] OR sensitivity/precision[Title/Abstract] OR sensitivity/predictive[Title/Abstract] OR sensitivity/preference[Title/Abstract] OR sensitivity/production[Title/Abstract] OR sensitivity/prognosis[Title/Abstract] OR sensitivity/quality[Title/Abstract] OR sensitivity/reactivity[Title/Abstract] OR sensitivity/recall[Title/Abstract] OR sensitivity/refractivity[Title/Abstract] OR sensitivity/refractoriness[Title/Abstract] OR sensitivity/reliability[Title/Abstract] OR sensitivity/reproducibility[Title/Abstract] OR sensitivity/resilience[Title/Abstract] OR sensitivity/resistance[Title/Abstract] OR sensitivity/resistancy[Title/Abstract] OR sensitivity/resolution[Title/Abstract] OR sensitivity/respect[Title/Abstract] OR sensitivity/response[Title/Abstract] OR sensitivity/responses[Title/Abstract] OR sensitivity/responsiveness[Title/Abstract] OR sensitivity/responsivity[Title/Abstract] OR sensitivity/robustness[Title/Abstract] OR sensitivity/sampling[Title/Abstract] OR sensitivity/scenario[Title/Abstract] OR sensitivity/secretion[Title/Abstract] OR sensitivity/selectivity[Title/Abstract] OR sensitivity/sensibility[Title/Abstract] OR sensitivity/serum[Title/Abstract] OR sensitivity/social[Title/Abstract] OR sensitivity/specificities[Title/Abstract] OR sensitivity/specificity[Title/Abstract] OR sensitivity/specificity/accuracy[Title/Abstract] OR sensitivity/specificity/and[Title/Abstract] OR sensitivity/specificity/area[Title/Abstract] OR sensitivity/specificity/auc[Title/Abstract] OR sensitivity/specificity/negative[Title/Abstract] OR sensitivity/specificity/overall[Title/Abstract] OR sensitivity/specificity/positive[Title/Abstract] OR sensitivity/specificity/ppv[Title/Abstract] OR sensitivity/specificity/ppv/npv[Title/Abstract] OR sensitivity/stability[Title/Abstract] OR sensitivity/states[Title/Abstract] OR sensitivity/subgroups[Title/Abstract] OR sensitivity/susceptibility[Title/Abstract] OR sensitivity/tanning[Title/Abstract] OR sensitivity/time[Title/Abstract] OR sensitivity/tolerance[Title/Abstract] OR sensitivity/toxicity[Title/Abstract] OR sensitivity/type[Title/Abstract] OR sensitivity/uncertainty[Title/Abstract] OR sensitivity/unit[Title/Abstract] OR sensitivity/variance[Title/Abstract] OR sensitivity'[Title/Abstract] OR sensitivity'comt[Title/Abstract] OR sensitivity's[Title/Abstract] OR sensitivity1[Title/Abstract] OR sensitivity28[Title/Abstract] OR sensitivity5[Title/Abstract] OR sensitivityand[Title/Abstract] OR sensitivitycalizationand[Title/Abstract] OR sensitivityfunction[Title/Abstract] OR sensitivityhits[Title/Abstract] OR sensitivityinconclusive[Title/Abstract] OR sensitivityincreased[Title/Abstract] OR sensitivitykij[Title/Abstract] OR sensitivityno[Title/Abstract] OR sensitivityof[Title/Abstract] OR sensitivityspecificitypositive[Title/Abstract] OR sensitivitytesting[Title/Abstract] OR sensitivityto[Title/Abstract] OR sensitivityvery[Title/Abstract] OR sensitivityxstress[Title/Abstract] OR sensitivive[Title/Abstract] OR sensitiviy[Title/Abstract] OR sensitivization[Title/Abstract] OR sensitivized[Title/Abstract] OR sensitivo[Title/Abstract] OR sensitivomotor[Title/Abstract] OR sensitivrty[Title/Abstract] OR sensitivtities[Title/Abstract] OR sensitivtity[Title/Abstract] OR sensitivty[Title/Abstract] OR sensitivum[Title/Abstract] OR sensitivus[Title/Abstract] OR sensitivy[Title/Abstract] OR sensitivyt[Title/Abstract]) OR "sensitivity and specificity"[MeSH Terms] OR (diagnos[Title/Abstract] OR diagnos's[Title/Abstract] OR diagnos1[Title/Abstract] OR diagnos1/spss[Title/Abstract] OR diagnosa[Title/Abstract] OR diagnosability[Title/Abstract] OR diagnosable[Title/Abstract] OR diagnosable'[Title/Abstract] OR diagnosably[Title/Abstract] OR diagnoscitur[Title/Abstract] OR diagnoscope[Title/Abstract] OR diagnoscopy[Title/Abstract] OR diagnose[Title/Abstract] OR diagnose/1[Title/Abstract] OR diagnose/assess[Title/Abstract] OR diagnose/classify[Title/Abstract] OR diagnose/counsel[Title/Abstract] OR diagnose/exclude[Title/Abstract] OR diagnose/localize[Title/Abstract] OR diagnose/predict[Title/Abstract] OR diagnose/treat[Title/Abstract] OR diagnose'[Title/Abstract] OR diagnose's[Title/Abstract] OR diagnose10[Title/Abstract] OR diagnosea[Title/Abstract] OR diagnoseable[Title/Abstract] OR diagnosed[Title/Abstract] OR diagnosed/controlled[Title/Abstract] OR diagnosed/culture[Title/Abstract] OR diagnosed/identified[Title/Abstract] OR diagnosed/managed[Title/Abstract] OR diagnosed/pretreated[Title/Abstract] OR diagnosed/receiving[Title/Abstract] OR diagnosed/recommended[Title/Abstract] OR diagnosed/refractory[Title/Abstract] OR diagnosed/registered[Title/Abstract] OR diagnosed/relapsed[Title/Abstract] OR diagnosed/reported[Title/Abstract] OR diagnosed/suggested[Title/Abstract] OR diagnosed/suspected[Title/Abstract] OR diagnosed/treated[Title/Abstract] OR diagnosed/uncontrolled[Title/Abstract] OR diagnosed/undiagnosed[Title/Abstract] OR diagnosed/untreated[Title/Abstract] OR diagnosed/year[Title/Abstract] OR diagnosed'[Title/Abstract] OR diagnosedbefore[Title/Abstract] OR diagnosedd[Title/Abstract] OR diagnosedfrom[Title/Abstract] OR diagnosedwith[Title/Abstract] OR diagnosefinder[Title/Abstract] OR diagnosefor[Title/Abstract] OR diagnoseis[Title/Abstract] OR diagnoseit[Title/Abstract] OR diagnoselt[Title/Abstract] OR diagnosen[Title/Abstract] OR diagnosenthesaurus[Title/Abstract] OR diagnoseof[Title/Abstract] OR diagnosepreoperatively[Title/Abstract] OR diagnoser[Title/Abstract] OR diagnosers[Title/Abstract] OR diagnoses[Title/Abstract] OR diagnoses/1[Title/Abstract] OR diagnoses/1,000[Title/Abstract] OR diagnoses/all[Title/Abstract] OR diagnoses/antenatally[Title/Abstract] OR diagnoses/avoided[Title/Abstract] OR diagnoses/biopsy[Title/Abstract] OR diagnoses/cat[Title/Abstract] OR diagnoses/characteristics[Title/Abstract] OR diagnoses/client[Title/Abstract] OR diagnoses/complications[Title/Abstract] OR diagnoses/conditions[Title/Abstract] OR diagnoses/cytologic[Title/Abstract] OR diagnoses/diagnosis[Title/Abstract] OR diagnoses/dog[Title/Abstract] OR diagnoses/events[Title/Abstract] OR diagnoses/indications[Title/Abstract] OR diagnoses/labels[Title/Abstract] OR diagnoses/management[Title/Abstract] OR diagnoses/needs[Title/Abstract] OR diagnoses/number[Title/Abstract] OR diagnoses/outcomes[Title/Abstract] OR diagnoses/pathogenetic[Title/Abstract] OR diagnoses/patient[Title/Abstract] OR diagnoses/prescriptions[Title/Abstract] OR diagnoses/problems[Title/Abstract] OR diagnoses/procedures[Title/Abstract] OR diagnoses/subject[Title/Abstract] OR diagnoses/subtype[Title/Abstract] OR diagnoses/symptoms[Title/Abstract] OR diagnoses/therapeutics[Title/Abstract] OR diagnoses/treatment[Title/Abstract] OR diagnoses/year[Title/Abstract] OR diagnoses/yr[Title/Abstract] OR diagnoses'[Title/Abstract] OR diagnosesby[Title/Abstract] OR diagnosese[Title/Abstract] OR diagnosess[Title/Abstract] OR diagnosesystem[Title/Abstract] OR diagnosi[Title/Abstract] OR diagnosia[Title/Abstract] OR diagnosible[Title/Abstract] OR diagnosic[Title/Abstract] OR diagnosica[Title/Abstract] OR diagnosics[Title/Abstract] OR diagnosid[Title/Abstract] OR diagnosied[Title/Abstract] OR diagnosies[Title/Abstract] OR diagnosilic[Title/Abstract] OR diagnosin[Title/Abstract] OR diagnosing[Title/Abstract] OR diagnosing/assessing[Title/Abstract] OR diagnosing/correcting[Title/Abstract] OR diagnosing/excluding[Title/Abstract] OR diagnosing/managing[Title/Abstract] OR diagnosing/monitoring[Title/Abstract] OR diagnosing/ruling[Title/Abstract] OR diagnosing/staging[Title/Abstract] OR diagnosing/treating[Title/Abstract] OR diagnosing'[Title/Abstract] OR diagnosingdelay[Title/Abstract] OR diagnosingpediatric[Title/Abstract] OR diagnosings[Title/Abstract] OR diagnosingsmall[Title/Abstract] OR diagnosingvcd[Title/Abstract] OR diagnosipothalumus[Title/Abstract] OR diagnosis[Title/Abstract] OR diagnosis/1[Title/Abstract] OR diagnosis/48[Title/Abstract] OR diagnosis/a[Title/Abstract] OR diagnosis/acr[Title/Abstract] OR diagnosis/aggression[Title/Abstract] OR diagnosis/antibiotic[Title/Abstract] OR diagnosis/application[Title/Abstract] OR diagnosis/ascertainment[Title/Abstract] OR diagnosis/assessment[Title/Abstract] OR diagnosis/assessment/monitoring[Title/Abstract] OR diagnosis/asthma[Title/Abstract] OR diagnosis/before[Title/Abstract] OR diagnosis/care[Title/Abstract] OR diagnosis/case[Title/Abstract] OR diagnosis/cause[Title/Abstract] OR diagnosis/classification[Title/Abstract] OR diagnosis/clinical[Title/Abstract] OR diagnosis/complaint[Title/Abstract] OR diagnosis/complex[Title/Abstract] OR diagnosis/condition[Title/Abstract] OR diagnosis/confirmation[Title/Abstract] OR diagnosis/consultation[Title/Abstract] OR diagnosis/context[Title/Abstract] OR diagnosis/control[Title/Abstract] OR diagnosis/control/complications[Title/Abstract] OR diagnosis/counselling[Title/Abstract] OR diagnosis/cpt[Title/Abstract] OR diagnosis/cytologic[Title/Abstract] OR diagnosis/decision[Title/Abstract] OR diagnosis/definition[Title/Abstract] OR diagnosis/delict[Title/Abstract] OR diagnosis/detection[Title/Abstract] OR diagnosis/determination[Title/Abstract] OR diagnosis/development[Title/Abstract] OR diagnosis/development/research[Title/Abstract] OR diagnosis/diagnoses[Title/Abstract] OR diagnosis/differential[Title/Abstract] OR diagnosis/dimension[Title/Abstract] OR diagnosis/direct[Title/Abstract] OR diagnosis/disease[Title/Abstract] OR diagnosis/early[Title/Abstract] OR diagnosis/effective[Title/Abstract] OR diagnosis/emergency[Title/Abstract] OR diagnosis/end[Title/Abstract] OR diagnosis/entry[Title/Abstract] OR diagnosis/epidemiology/therapy[Title/Abstract] OR diagnosis/es[Title/Abstract] OR diagnosis/evaluation[Title/Abstract] OR diagnosis/evaluation/prescription[Title/Abstract] OR diagnosis/event[Title/Abstract] OR diagnosis/exclude[Title/Abstract] OR diagnosis/exclusion[Title/Abstract] OR diagnosis/exploration[Title/Abstract] OR diagnosis/exposure[Title/Abstract] OR diagnosis/follow[Title/Abstract] OR diagnosis/functional[Title/Abstract] OR diagnosis/genetics[Title/Abstract] OR diagnosis/genetics/psychology[Title/Abstract] OR diagnosis/grade[Title/Abstract] OR diagnosis/grading[Title/Abstract] OR diagnosis/he/she[Title/Abstract] OR diagnosis/health[Title/Abstract] OR diagnosis/holistic[Title/Abstract] OR diagnosis/hospice[Title/Abstract] OR diagnosis/hospitalization[Title/Abstract] OR diagnosis/human[Title/Abstract] OR diagnosis/hypothesized[Title/Abstract] OR diagnosis/imaging[Title/Abstract] OR diagnosis/immunotherapy[Title/Abstract] OR diagnosis/inappropriate[Title/Abstract] OR diagnosis/index[Title/Abstract] OR diagnosis/indication[Title/Abstract] OR diagnosis/initial[Title/Abstract] OR diagnosis/initiation[Title/Abstract] OR diagnosis/insignificant[Title/Abstract] OR diagnosis/interpretation[Title/Abstract] OR diagnosis/intervention[Title/Abstract] OR diagnosis/intervention/outcome[Title/Abstract] OR diagnosis/interview[Title/Abstract] OR diagnosis/introduction[Title/Abstract] OR diagnosis/investigation[Title/Abstract] OR diagnosis/investigations[Title/Abstract] OR diagnosis/laboratory[Title/Abstract] OR diagnosis/length[Title/Abstract] OR diagnosis/ltx[Title/Abstract] OR diagnosis/management[Title/Abstract] OR diagnosis/matching[Title/Abstract] OR diagnosis/medical[Title/Abstract] OR diagnosis/medication[Title/Abstract] OR diagnosis/metastasis[Title/Abstract] OR diagnosis/misdiagnosis[Title/Abstract] OR diagnosis/missed[Title/Abstract] OR diagnosis/molecular[Title/Abstract] OR diagnosis/monitoring[Title/Abstract] OR diagnosis/month[Title/Abstract] OR diagnosis/needs[Title/Abstract] OR diagnosis/normal[Title/Abstract] OR diagnosis/nuclear[Title/Abstract] OR diagnosis/number[Title/Abstract] OR diagnosis/nursing[Title/Abstract] OR diagnosis/operation[Title/Abstract] OR diagnosis/oral[Title/Abstract] OR diagnosis/orientation[Title/Abstract] OR diagnosis/outcome[Title/Abstract] OR diagnosis/patient[Title/Abstract] OR diagnosis/physical[Title/Abstract] OR diagnosis/prediction[Title/Abstract] OR diagnosis/pregnancy[Title/Abstract] OR diagnosis/preimplantation[Title/Abstract] OR diagnosis/prevention[Title/Abstract] OR diagnosis/prevention/management[Title/Abstract] OR diagnosis/problem[Title/Abstract] OR diagnosis/procedural[Title/Abstract] OR diagnosis/procedure[Title/Abstract] OR diagnosis/prognosis[Title/Abstract] OR diagnosis/prognosis/therapy[Title/Abstract] OR diagnosis/prognostic[Title/Abstract] OR diagnosis/prognostics[Title/Abstract] OR diagnosis/pseudodiagnosis[Title/Abstract] OR diagnosis/recognition[Title/Abstract] OR diagnosis/recorded[Title/Abstract] OR diagnosis/recruitment[Title/Abstract] OR diagnosis/reference[Title/Abstract] OR diagnosis/referent[Title/Abstract] OR diagnosis/referral[Title/Abstract] OR diagnosis/relapse[Title/Abstract] OR diagnosis/remediation[Title/Abstract] OR diagnosis/removal[Title/Abstract] OR diagnosis/reporting[Title/Abstract] OR diagnosis/research[Title/Abstract] OR diagnosis/resection[Title/Abstract] OR diagnosis/root[Title/Abstract] OR diagnosis/screening[Title/Abstract] OR diagnosis/selection[Title/Abstract] OR diagnosis/significant[Title/Abstract] OR diagnosis/stage[Title/Abstract] OR diagnosis/staging[Title/Abstract] OR diagnosis/study[Title/Abstract] OR diagnosis/surgeon's[Title/Abstract] OR diagnosis/surgery[Title/Abstract] OR diagnosis/surgical[Title/Abstract] OR diagnosis/surveillance[Title/Abstract] OR diagnosis/suspected[Title/Abstract] OR diagnosis/suspicion[Title/Abstract] OR diagnosis/symptom[Title/Abstract] OR diagnosis/symptoms[Title/Abstract] OR diagnosis/task[Title/Abstract] OR diagnosis/taxonomy[Title/Abstract] OR diagnosis/therapeutics[Title/Abstract] OR diagnosis/therapy[Title/Abstract] OR diagnosis/therapy/prevention[Title/Abstract] OR diagnosis/therapy/referral[Title/Abstract] OR diagnosis/therapy/resistance[Title/Abstract] OR diagnosis/thrombolytic[Title/Abstract] OR diagnosis/total[Title/Abstract] OR diagnosis/transplantation[Title/Abstract] OR diagnosis/treatment[Title/Abstract] OR diagnosis/treatment/education[Title/Abstract] OR diagnosis/triage[Title/Abstract] OR diagnosis/ugct[Title/Abstract] OR diagnosis/understanding[Title/Abstract] OR diagnosis/upper[Title/Abstract] OR diagnosis/urography[Title/Abstract] OR diagnosis/year[Title/Abstract] OR diagnosis'[Title/Abstract] OR diagnosis''[Title/Abstract] OR diagnosis's[Title/Abstract] OR diagnosis1[Title/Abstract] OR diagnosis6[Title/Abstract] OR diagnosisa[Title/Abstract] OR diagnosisan[Title/Abstract] OR diagnosisand[Title/Abstract] OR diagnosisbut[Title/Abstract] OR diagnosiscare[Title/Abstract] OR diagnosisdirectness[Title/Abstract] OR diagnosised[Title/Abstract] OR diagnosises[Title/Abstract] OR diagnosisf[Title/Abstract] OR diagnosisi[Title/Abstract] OR diagnosising[Title/Abstract] OR diagnosisjoint[Title/Abstract] OR diagnosisng[Title/Abstract] OR diagnosiso[Title/Abstract] OR diagnosisof[Title/Abstract] OR diagnosispostoperative[Title/Abstract] OR diagnosisrelated[Title/Abstract] OR diagnosiss[Title/Abstract] OR diagnosissff[Title/Abstract] OR diagnosisspecific[Title/Abstract] OR diagnosisthe[Title/Abstract] OR diagnosistic[Title/Abstract] OR diagnosisto[Title/Abstract] OR diagnosisuntypical[Title/Abstract] OR diagnosiswasn't[Title/Abstract] OR diagnosisxdrugxtime[Title/Abstract] OR diagnosisxgenotype[Title/Abstract] OR diagnosisxsessionxmec[Title/Abstract] OR diagnosisxtime[Title/Abstract] OR diagnosit[Title/Abstract] OR diagnositc[Title/Abstract] OR diagnositcs[Title/Abstract] OR diagnositic[Title/Abstract] OR diagnositicity[Title/Abstract] OR diagnositics[Title/Abstract] OR diagnositika[Title/Abstract] OR diagnositsc[Title/Abstract] OR diagnosized[Title/Abstract] OR diagnoskin[Title/Abstract] OR diagnosoft[Title/Abstract] OR diagnosogenic[Title/Abstract] OR diagnosos[Title/Abstract] OR diagnoss[Title/Abstract] OR diagnossi[Title/Abstract] OR diagnossing[Title/Abstract] OR diagnossis[Title/Abstract] OR diagnost[Title/Abstract] OR diagnostant[Title/Abstract] OR diagnostc[Title/Abstract] OR diagnostci[Title/Abstract] OR diagnostec[Title/Abstract] OR diagnosted[Title/Abstract] OR diagnostek[Title/Abstract] OR diagnostest[Title/Abstract] OR diagnosti[Title/Abstract] OR diagnosti1c[Title/Abstract] OR diagnostial[Title/Abstract] OR diagnostians[Title/Abstract] OR diagnostic[Title/Abstract] OR diagnostic/33[Title/Abstract] OR diagnostic/ablation[Title/Abstract] OR diagnostic/adequate[Title/Abstract] OR diagnostic/analytical[Title/Abstract] OR diagnostic/antigenic[Title/Abstract] OR diagnostic/assessment[Title/Abstract] OR diagnostic/average[Title/Abstract] OR diagnostic/benign[Title/Abstract] OR diagnostic/biochemical[Title/Abstract] OR diagnostic/biological[Title/Abstract] OR diagnostic/biomedical[Title/Abstract] OR diagnostic/cardiac[Title/Abstract] OR diagnostic/certifying[Title/Abstract] OR diagnostic/characterization[Title/Abstract] OR diagnostic/classification[Title/Abstract] OR diagnostic/clinical[Title/Abstract] OR diagnostic/clinical/therapeutic[Title/Abstract] OR diagnostic/coding[Title/Abstract] OR diagnostic/complete[Title/Abstract] OR diagnostic/counseling[Title/Abstract] OR diagnostic/cpap[Title/Abstract] OR diagnostic/decision[Title/Abstract] OR diagnostic/demographic[Title/Abstract] OR diagnostic/developmental[Title/Abstract] OR diagnostic/diagnostic[Title/Abstract] OR diagnostic/disease[Title/Abstract] OR diagnostic/early[Title/Abstract] OR diagnostic/etiologic[Title/Abstract] OR diagnostic/evaluative[Title/Abstract] OR diagnostic/first[Title/Abstract] OR diagnostic/follow[Title/Abstract] OR diagnostic/formulation[Title/Abstract] OR diagnostic/genetic[Title/Abstract] OR diagnostic/genetics[Title/Abstract] OR diagnostic/gps[Title/Abstract] OR diagnostic/imaging[Title/Abstract] OR diagnostic/inclusion[Title/Abstract] OR diagnostic/interpersonal/intrapsychic[Title/Abstract] OR diagnostic/interpretive[Title/Abstract] OR diagnostic/intervention[Title/Abstract] OR diagnostic/interventional[Title/Abstract] OR diagnostic/interventions[Title/Abstract] OR diagnostic/invasive[Title/Abstract] OR diagnostic/investigative[Title/Abstract] OR diagnostic/laboratory[Title/Abstract] OR diagnostic/management[Title/Abstract] OR diagnostic/measurement[Title/Abstract] OR diagnostic/monitoring[Title/Abstract] OR diagnostic/negative[Title/Abstract] OR diagnostic/new[Title/Abstract] OR diagnostic/nondiagnostic[Title/Abstract] OR diagnostic/nosological[Title/Abstract] OR diagnostic/operating[Title/Abstract] OR diagnostic/ OR Title/Abstract OR diagnostic/pathogenic[Title/Abstract] OR diagnostic/pathologic[Title/Abstract] OR diagnostic/patient[Title/Abstract] OR diagnostic/paucicellular[Title/Abstract] OR diagnostic/perfect[Title/Abstract] OR diagnostic/planning[Title/Abstract] OR diagnostic/practical[Title/Abstract] OR diagnostic/prediagnostic[Title/Abstract] OR diagnostic/predictive[Title/Abstract] OR diagnostic/prescriptive[Title/Abstract] OR diagnostic/preventive[Title/Abstract] OR diagnostic/procedural[Title/Abstract] OR diagnostic/prognostic[Title/Abstract] OR diagnostic/prognostic/therapeutic[Title/Abstract] OR diagnostic/pronostic[Title/Abstract] OR diagnostic/psychiatric[Title/Abstract] OR diagnostic/real[Title/Abstract] OR diagnostic/reference[Title/Abstract] OR diagnostic/rehabilitation[Title/Abstract] OR diagnostic/relapse[Title/Abstract] OR diagnostic/relapsed[Title/Abstract] OR diagnostic/remedial[Title/Abstract] OR diagnostic/screening[Title/Abstract] OR diagnostic/sensititre[Title/Abstract] OR diagnostic/site[Title/Abstract] OR diagnostic/sociodemographic[Title/Abstract] OR diagnostic/staging[Title/Abstract] OR diagnostic/structure[Title/Abstract] OR diagnostic/suggestive[Title/Abstract] OR diagnostic/superior[Title/Abstract] OR diagnostic/surgical[Title/Abstract] OR diagnostic/surveillance[Title/Abstract] OR diagnostic/symptomatic[Title/Abstract] OR diagnostic/syndromic[Title/Abstract] OR diagnostic/therapeutic[Title/Abstract] OR diagnostic/therapeutic/prognostic[Title/Abstract] OR diagnostic/therapeutical[Title/Abstract] OR diagnostic/transplant[Title/Abstract] OR diagnostic/treatment[Title/Abstract] OR diagnostic'[Title/Abstract] OR diagnostic's[Title/Abstract] OR diagnostica[Title/Abstract] OR diagnosticable[Title/Abstract] OR diagnosticado[Title/Abstract] OR diagnosticados[Title/Abstract] OR diagnostical[Title/Abstract] OR diagnostical/therapeutical[Title/Abstract] OR diagnostical's[Title/Abstract] OR diagnostically[Title/Abstract] OR diagnostically/prognostically[Title/Abstract] OR diagnostically/therapeutically[Title/Abstract] OR diagnosticals[Title/Abstract] OR diagnosticand[Title/Abstract] OR diagnosticand/ OR Title/Abstract OR diagnosticans[Title/Abstract] OR diagnosticar[Title/Abstract] OR diagnosticas[Title/Abstract] OR diagnosticastago[Title/Abstract] OR diagnosticat[Title/Abstract] OR diagnosticate[Title/Abstract] OR diagnosticated[Title/Abstract] OR diagnosticating[Title/Abstract] OR diagnostication[Title/Abstract] OR diagnosticc[Title/Abstract] OR diagnosticdilemma[Title/Abstract] OR diagnostice[Title/Abstract] OR diagnosticed[Title/Abstract] OR diagnostices[Title/Abstract] OR diagnosticexperiment[Title/Abstract] OR diagnosticheskaia[Title/Abstract] OR diagnosticheskiye[Title/Abstract] OR diagnostici[Title/Abstract] OR diagnostician[Title/Abstract] OR diagnostician's[Title/Abstract] OR diagnosticians[Title/Abstract] OR diagnosticians'[Title/Abstract] OR diagnosticing[Title/Abstract] OR diagnosticis[Title/Abstract] OR diagnosticised[Title/Abstract] OR diagnosticities[Title/Abstract] OR diagnosticity[Title/Abstract] OR diagnosticity's[Title/Abstract] OR diagnosticizable[Title/Abstract] OR diagnosticized[Title/Abstract] OR diagnostick[Title/Abstract] OR diagnostickeho[Title/Abstract] OR diagnosticly[Title/Abstract] OR diagnosticmethods[Title/Abstract] OR diagnosticmorphology[Title/Abstract] OR diagnostico[Title/Abstract] OR diagnosticoinstrumental[Title/Abstract] OR diagnosticos[Title/Abstract] OR diagnosticosurgical[Title/Abstract] OR diagnosticotherapeutic[Title/Abstract] OR diagnosticpathology[Title/Abstract] OR diagnosticphenomenon[Title/Abstract] OR diagnosticprocedure[Title/Abstract] OR diagnostics[Title/Abstract] OR diagnostics/bionanotechnology[Title/Abstract] OR diagnostics/boehringer[Title/Abstract] OR diagnostics/centocor[Title/Abstract] OR diagnostics/detection[Title/Abstract] OR diagnostics/differential[Title/Abstract] OR diagnostics/elderly[Title/Abstract] OR diagnostics/genotyping[Title/Abstract] OR diagnostics/hitachi[Title/Abstract] OR diagnostics/imaging[Title/Abstract] OR diagnostics/intervet[Title/Abstract] OR diagnostics/monitoring[Title/Abstract] OR diagnostics/murex[Title/Abstract] OR diagnostics/prognostics[Title/Abstract] OR diagnostics/protein[Title/Abstract] OR diagnostics/screening[Title/Abstract] OR diagnostics/therapeutics[Title/Abstract] OR diagnostics/treatment[Title/Abstract] OR diagnostics/vaccines[Title/Abstract] OR diagnostics'[Title/Abstract] OR diagnostics's[Title/Abstract] OR diagnostictests[Title/Abstract] OR diagnosticum[Title/Abstract] OR diagnosticum's[Title/Abstract] OR diagnosticums[Title/Abstract] OR diagnosticus[Title/Abstract] OR diagnosticwork[Title/Abstract] OR diagnostie[Title/Abstract] OR diagnostiek[Title/Abstract] OR diagnosties[Title/Abstract] OR diagnostification[Title/Abstract] OR diagnostified[Title/Abstract] OR diagnostig[Title/Abstract] OR diagnostiga[Title/Abstract] OR diagnostik[Title/Abstract] OR diagnostika[Title/Abstract] OR diagnostika'[Title/Abstract] OR diagnostikgeratehersteller[Title/Abstract] OR diagnostiki[Title/Abstract] OR diagnostikinstrument[Title/Abstract] OR diagnostikum[Title/Abstract] OR diagnosting[Title/Abstract] OR diagnostiqiagnosis[Title/Abstract] OR diagnostique[Title/Abstract] OR diagnostiquee[Title/Abstract] OR diagnostiques[Title/Abstract] OR diagnostis[Title/Abstract] OR diagnostisch[Title/Abstract] OR diagnostische[Title/Abstract] OR diagnostischen[Title/Abstract] OR diagnostischer[Title/Abstract] OR diagnostisches[Title/Abstract] OR diagnostised[Title/Abstract] OR diagnostisis[Title/Abstract] OR diagnostisized[Title/Abstract] OR diagnostiv[Title/Abstract] OR diagnostive[Title/Abstract] OR diagnostix[Title/Abstract] OR diagnostized[Title/Abstract] OR diagnostotube[Title/Abstract] OR diagnostricks[Title/Abstract] OR diagnostrix[Title/Abstract] OR diagnosttc[Title/Abstract] OR diagnosttrade[Title/Abstract] OR diagnostyce[Title/Abstract] OR diagnostyki[Title/Abstract] OR diagnosus[Title/Abstract] OR diagnosy[Title/Abstract] OR diagnosys[Title/Abstract] OR diagnoszed[Title/Abstract]) OR "diagnosis"[MeSH Terms:noexp] OR (diagnostic equipment[MeSH:noexp] OR diagnostic equipment/classification[MeSH:noexp] OR diagnostic equipment/economics[MeSH:noexp] OR diagnostic equipment/ethics[MeSH:noexp] OR diagnostic equipment/history[MeSH:noexp] OR diagnostic equipment/microbiology[MeSH:noexp] OR diagnostic equipment/standards[MeSH:noexp] OR diagnostic equipment/trends[MeSH:noexp] OR diagnostic equipment/utilization[MeSH:noexp] OR diagnostic equipment/veterinary[MeSH:noexp] OR diagnostic errors[MeSH:noexp] OR diagnostic errors/classification[MeSH:noexp] OR diagnostic errors/economics[MeSH:noexp] OR diagnostic errors/ethics[MeSH:noexp] OR diagnostic errors/history[MeSH:noexp] OR diagnostic errors/instrumentation[MeSH:noexp] OR diagnostic errors/methods[MeSH:noexp] OR diagnostic errors/mortality[MeSH:noexp] OR diagnostic errors/nursing[MeSH:noexp] OR diagnostic errors/psychology[MeSH:noexp] OR diagnostic errors/standards[MeSH:noexp] OR diagnostic errors/trends[MeSH:noexp] OR diagnostic errors/veterinary[MeSH:noexp] OR diagnostic imaging[MeSH:noexp] OR diagnostic imaging/classification[MeSH:noexp] OR diagnostic imaging/contraindications[MeSH:noexp] OR diagnostic imaging/economics[MeSH:noexp] OR diagnostic imaging/education[MeSH:noexp] OR diagnostic imaging/ethics[MeSH:noexp] OR diagnostic imaging/history[MeSH:noexp] OR diagnostic imaging/instrumentation[MeSH:noexp] OR diagnostic imaging/methods[MeSH:noexp] OR diagnostic imaging/mortality[MeSH:noexp] OR diagnostic imaging/nursing[MeSH:noexp] OR diagnostic imaging/psychology[MeSH:noexp] OR diagnostic imaging/standards[MeSH:noexp] OR diagnostic imaging/trends[MeSH:noexp] OR diagnostic imaging/utilization[MeSH:noexp] OR diagnostic imaging/veterinary[MeSH:noexp] OR diagnostic services[MeSH:noexp] OR diagnostic services/classification[MeSH:noexp] OR diagnostic services/economics[MeSH:noexp] OR diagnostic services/ethics[MeSH:noexp] OR diagnostic services/history[MeSH:noexp] OR diagnostic services/manpower[MeSH:noexp] OR diagnostic services/standards[MeSH:noexp] OR diagnostic services/trends[MeSH:noexp] OR diagnostic services/utilization[MeSH:noexp]) OR "diagnosis, differential"[MeSH Terms:noexp] OR "diagnosis"[Subheading:noexp]) AND "humans"[MeSH Terms]

Choledocholithiasis therapie choledochotomie

((((("common bile duct"[MeSH Terms] OR ("common"[All Fields] AND "bile"[All Fields] AND "duct"[All Fields]) OR "common bile duct"[All Fields]) OR biliary[All Fields]) AND (("calculi"[MeSH Terms] OR "calculi"[All Fields] OR "stone"[All Fields]) OR ("calculi"[MeSH Terms] OR "calculi"[All Fields]))) OR ("choledocholithiasis"[MeSH Terms] OR "choledocholithiasis"[All Fields])) AND (("laparoscopy"[MeSH Terms] OR "laparoscopy"[All Fields] OR "laparoscopic"[All Fields]) AND ((("common bile duct"[MeSH Terms] OR ("common"[All Fields] AND "bile"[All Fields] AND "duct"[All Fields]) OR "common bile duct"[All Fields]) AND exploration[All Fields]) OR choledochotomy[All Fields])) AND (("therapy"[Subheading] OR "therapy"[All Fields] OR "therapeutics"[MeSH Terms] OR "therapeutics"[All Fields]) OR ("therapy"[Subheading] OR "therapy"[All Fields] OR "treatment"[All Fields] OR "therapeutics"[MeSH Terms] OR "therapeutics"[All Fields]))) AND ((clinical[Title/Abstract] AND trial[Title/Abstract]) OR "clinical trials as topic"[MeSH Terms] OR clinical trial[Publication Type] OR (random[Title/Abstract] OR random/aleatory[Title/Abstract] OR random/aligned[Title/Abstract] OR random/and[Title/Abstract] OR random/arm[Title/Abstract] OR random/basal[Title/Abstract] OR random/blind[Title/Abstract] OR random/block[Title/Abstract] OR random/blocked[Title/Abstract] OR random/cdp[Title/Abstract] OR random/clustered[Title/Abstract] OR random/combinatorial[Title/Abstract] OR random/double[Title/Abstract] OR random/ethanol[Title/Abstract] OR random/extended[Title/Abstract] OR random/fixed[Title/Abstract] OR random/half[Title/Abstract] OR random/irrelevant[Title/Abstract] OR random/linkage[Title/Abstract] OR random/matched[Title/Abstract] OR random/mixed[Title/Abstract] OR random/nonrandom[Title/Abstract] OR random/orthogonal[Title/Abstract] OR random/random[Title/Abstract] OR random/representative[Title/Abstract] OR random/systematic[Title/Abstract] OR random/turns[Title/Abstract] OR random'[Title/Abstract] OR random1[Title/Abstract] OR random1y[Title/Abstract] OR randomally[Title/Abstract] OR randomaly[Title/Abstract] OR randomamplified[Title/Abstract] OR randoman[Title/Abstract] OR randomand[Title/Abstract] OR randomate[Title/Abstract] OR randombalance[Title/Abstract] OR randombred[Title/Abstract] OR randombreds[Title/Abstract] OR randomcoil[Title/Abstract] OR randomdigit[Title/Abstract] OR randomdot[Title/Abstract] OR randome[Title/Abstract] OR randomed[Title/Abstract] OR randomeffects[Title/Abstract] OR randomely[Title/Abstract] OR randomer[Title/Abstract] OR randomezed[Title/Abstract] OR randomforest[Title/Abstract] OR randomfrog[Title/Abstract] OR randomi[Title/Abstract] OR randomiazed[Title/Abstract] OR randomic[Title/Abstract] OR randomically[Title/Abstract] OR randomicaly[Title/Abstract] OR randomiced[Title/Abstract] OR randomicity[Title/Abstract] OR randomied[Title/Abstract] OR randomifzed[Title/Abstract] OR randomil[Title/Abstract] OR randomily[Title/Abstract] OR randomin[Title/Abstract] OR randomined[Title/Abstract] OR randomingly[Title/Abstract] OR randominization[Title/Abstract] OR randominzed[Title/Abstract] OR randomirrespective[Title/Abstract] OR randomis[Title/Abstract] OR randomisation[Title/Abstract] OR randomisation'[Title/Abstract] OR randomisations[Title/Abstract] OR randomisationsecondary[Title/Abstract] OR randomisd[Title/Abstract] OR randomise[Title/Abstract] OR randomised[Title/Abstract] OR randomised/controlled[Title/Abstract] OR randomised/crossover[Title/Abstract] OR randomised/eligible[Title/Abstract] OR randomised/observational[Title/Abstract] OR randomised'[Title/Abstract] OR randomisedrandomised[Title/Abstract] OR randomisee[Title/Abstract] OR randomisees[Title/Abstract] OR randomisely[Title/Abstract] OR randomises[Title/Abstract] OR randomisiert[Title/Abstract] OR randomisierte[Title/Abstract] OR randomisierung[Title/Abstract] OR randomising[Title/Abstract] OR randomisly[Title/Abstract] OR randomiz[Title/Abstract] OR randomizable[Title/Abstract] OR randomizadely[Title/Abstract] OR randomizado[Title/Abstract] OR randomizaion[Title/Abstract] OR randomization[Title/Abstract] OR randomization/allocation[Title/Abstract] OR randomization/baseline[Title/Abstract] OR randomization/blinding[Title/Abstract] OR randomization/diversification[Title/Abstract] OR randomization/matching[Title/Abstract] OR randomization/nonspecificity[Title/Abstract] OR randomization/permutation[Title/Abstract] OR randomization/registration[Title/Abstract] OR randomization/selection[Title/Abstract] OR randomization/stabilization[Title/Abstract] OR randomization/start[Title/Abstract] OR randomization'[Title/Abstract] OR randomizationin[Title/Abstract] OR randomizations[Title/Abstract] OR randomizationstudies[Title/Abstract] OR randomizd[Title/Abstract] OR randomize[Title/Abstract] OR randomized[Title/Abstract] OR randomized/15[Title/Abstract] OR randomized/455[Title/Abstract] OR randomized/58[Title/Abstract] OR randomized/blind[Title/Abstract] OR randomized/blinded[Title/Abstract] OR randomized/controlled[Title/Abstract] OR randomized/counterbalanced[Title/Abstract] OR randomized/nonrandomized[Title/Abstract] OR randomized/organized[Title/Abstract] OR randomized/prospective[Title/Abstract] OR randomized/quasirandomized[Title/Abstract] OR randomized/randomized[Title/Abstract] OR randomized/registry[Title/Abstract] OR randomized/screened[Title/Abstract] OR randomized/stratified[Title/Abstract] OR randomized'[Title/Abstract] OR randomized150[Title/Abstract] OR randomizedcrossover[Title/Abstract] OR randomizedduring[Title/Abstract] OR randomizedly[Title/Abstract] OR randomizedphase[Title/Abstract] OR randomizedto[Title/Abstract] OR randomizedtrial[Title/Abstract] OR randomizely[Title/Abstract] OR randomizer[Title/Abstract] OR randomizer'[Title/Abstract] OR randomizes[Title/Abstract] OR randomizied[Title/Abstract] OR randomizing[Title/Abstract] OR randomizing'[Title/Abstract] OR randomizingly[Title/Abstract] OR randomizzati[Title/Abstract] OR randomjungle[Title/Abstract] OR randoml[Title/Abstract] OR randomlike[Title/Abstract] OR randomlly[Title/Abstract] OR randomly[Title/Abstract] OR randomly/linearly[Title/Abstract] OR randomly'[Title/Abstract] OR randomlyassigned[Title/Abstract] OR randomlyselected[Title/Abstract] OR randomlyuniformly[Title/Abstract] OR randommess[Title/Abstract] OR randommethacrylic[Title/Abstract] OR randommized[Title/Abstract] OR randommobility[Title/Abstract] OR randomnes[Title/Abstract] OR randomness[Title/Abstract] OR randomness'[Title/Abstract] OR randomnesses[Title/Abstract] OR randomnicity[Title/Abstract] OR randomnized[Title/Abstract] OR randomnly[Title/Abstract] OR randomomized[Title/Abstract] OR randompf[Title/Abstract] OR randompod[Title/Abstract] OR randompower[Title/Abstract] OR randoms[Title/Abstract] OR randoms'[Title/Abstract] OR randomsample[Title/Abstract] OR randomsed[Title/Abstract] OR randomsource[Title/Abstract] OR randomwalk[Title/Abstract] OR randomwalker[Title/Abstract] OR randomwalksat[Title/Abstract] OR randomy[Title/Abstract] OR randomyl[Title/Abstract] OR randomyly[Title/Abstract] OR randomzed[Title/Abstract] OR randomzied[Title/Abstract] OR randomzing[Title/Abstract]) OR "random allocation"[MeSH Terms] OR "therapeutic use"[Subheading])

Cholelithiasis en ESWL

((("lithotripsy"[MeSH Terms] OR "lithotripsy"[All Fields]) OR eswl[All Fields]) AND (("gallstones"[MeSH Terms] OR "gallstones"[All Fields] OR "gallstone"[All Fields]) OR ("cholelithiasis"[MeSH Terms] OR "cholelithiasis"[All Fields]) OR ("cholecystolithiasis"[MeSH Terms] OR "cholecystolithiasis"[All Fields]) OR (("choledocholithiasis"[MeSH Terms] OR "choledocholithiasis"[All Fields]) OR (("common bile duct"[MeSH Terms] OR ("common"[All Fields] AND "bile"[All Fields] AND "duct"[All Fields]) OR "common bile duct"[All Fields]) AND stones[All Fields]))) AND (("therapy"[Subheading] OR "therapy"[All Fields] OR "therapeutics"[MeSH Terms] OR "therapeutics"[All Fields]) OR ("therapy"[Subheading] OR "therapy"[All Fields] OR "treatment"[All Fields] OR "therapeutics"[MeSH Terms] OR "therapeutics"[All Fields]))) AND (randomized controlled trial[Publication Type] OR (randomized[Title/Abstract] AND controlled[Title/Abstract] AND trial[Title/Abstract]))

Afwachten na eerste aanval

((first[All Fields] OR primary[All Fields]) AND (attack[All Fields] OR episode[All Fields] OR ("menstruation"[MeSH Terms] OR "menstruation"[All Fields] OR "period"[All Fields]))) AND (("gallstones"[MeSH Terms] OR "gallstones"[All Fields] OR "gallstone"[All Fields]) OR ("cholelithiasis"[MeSH Terms] OR "cholelithiasis"[All Fields]) OR ("cholecystolithiasis"[MeSH Terms] OR "cholecystolithiasis"[All Fields])) AND ("cholecystectomy"[MeSH Terms] OR "cholecystectomy"[All Fields]) AND (("observation"[MeSH Terms] OR "observation"[All Fields]) OR conservative[All Fields])

Medicatie cholelithiasis

(((("bile acids and salts"[MeSH Terms] OR ("bile"[All Fields] AND "acids"[All Fields] AND "salts"[All Fields]) OR "bile acids and salts"[All Fields] OR ("bile"[All Fields] AND "acid"[All Fields]) OR "bile acid"[All Fields]) AND ("therapy"[Subheading] OR "therapy"[All Fields] OR "therapeutics"[MeSH Terms] OR "therapeutics"[All Fields])) OR ("Behav Anal Today"[Journal] OR "bat"[All Fields]) OR ("ursodeoxycholic acid"[MeSH Terms] OR ("ursodeoxycholic"[All Fields] AND "acid"[All Fields]) OR "ursodeoxycholic acid"[All Fields])) AND (("gallstones"[MeSH Terms] OR "gallstones"[All Fields] OR "gallstone"[All Fields]) OR ("cholelithiasis"[MeSH Terms] OR "cholelithiasis"[All Fields]) OR ("cholecystolithiasis"[MeSH Terms] OR "cholecystolithiasis"[All Fields]) OR (("choledocholithiasis"[MeSH Terms] OR "choledocholithiasis"[All Fields]) OR (("common bile duct"[MeSH Terms] OR ("common"[All Fields] AND "bile"[All Fields] AND "duct"[All Fields]) OR "common bile duct"[All Fields]) AND stones[All Fields]))) AND (("therapy"[Subheading] OR "therapy"[All Fields] OR "therapeutics"[MeSH Terms] OR "therapeutics"[All Fields]) OR ("therapy"[Subheading] OR "therapy"[All Fields] OR "treatment"[All Fields] OR "therapeutics"[MeSH Terms] OR "therapeutics"[All Fields]))) AND (randomized controlled trial[Publication Type] OR (randomized[Title/Abstract] AND controlled[Title/Abstract] AND trial[Title/Abstract]))