Literatuuroverzicht toxiciteit intrathecale behandeling

Artikel

Steekproef

Interventie

Uitkomst

Shapiro 1977¹³³ 

MC

IV Ch

20/110 (15%) draindysf./infectie
IV Ch th compl 25%

Obbens 1985¹⁴²

387 pt(340 IV Ch)

IV Ch

27/320  Omm, complic. (13 Re-Ok)
19        infect. meningitis

Trump 1982¹⁴⁵ 

MC (31)

IV Ch

4/31     infect. meningitis

Stewart 1987¹³⁵ 

MC (20)

IV Ch

4 encefalopathie
1 myelopathie
3 insult

Hitchins 1987¹²³ 

MC 44

IT/IV Ch

1/44 acuut†
4/17 Ommaya infectie, (1 †)
5/17 Ommaya dysf (1 †)

Chamberlain 1987¹⁴⁴ 

MC/NHL 120

IV Ch

52 asept. meningitis
 9 infect. meningitis
10 drain probl. (7 Re-ok)
 2 leuko encefalopathie
 1 myelopathie
21 BM remming

Chamberlain 1998²¹⁸

long (32)

IV Ch

20/32 asept. meningitis
 4/32 BM remming
 2/32 infect. meningitis

Siegal 1994¹¹² 

MC/NHL

IV Ch/Non-IT

IV Ch: 59% leukoenc
non-IT:  0% leukoenc.

Lishner 1990¹⁴³

106 pt
(29 MC)

IV Ch

11/106 Ommaya probl (1†)
10/106 infect. meningitis (1†)

Boogerd 1991²⁶ 

MC (44)

IV Ch

 5/44 infect. meningitis (1†)
 1/44 MTX meningitis
1/44 intracr. bloeding
2/44 myelopathie
11/17 longsurv. leukoenc.

Balm 1996²² 

MC

IV Ch

Ommaya infectie        12%
             dysfunctie       3%
asept. meningitis          6%
leukoenc                    2%
insult                            2%

Bokstein 1998¹¹⁶ 

MC

IV/non-IT

IV ch: acute tox     31%, laat 20%
                              (> 50% at risk)
non-IT: acuut       0%,  laat  0%

Glantz 1999¹³¹ 

MC

MTX VS.
depot Ara-C

asept.  meningitis MTX  19%
                   depot Ara-C 23%

Jaeckle 2001¹³² 

MC

IT depot Ara-C

asept. meningitis           19%
hoofdpijn                       11%

Chamberlain 2002²¹⁹ 

MC

IV  FN

asept. meningitis           60%
chron.fatigue                 90%

Boogerd 2004¹¹⁴

MC

IV MTX/ non-IT

IV MTX: asept. meningitis 12%
Infect. meningitis  12%
Ommaya revisie  18%
Intracran. bloeding 12%
Late leukoencefalop. 18%
Non-IT: late leukoencefalopathie 6%