Kennislacunes

There is a large knowledge gap about the effect of prophylactic treatment in hypersensitivity reactions to contrast media. An extensive search was performed but no papers were found that met the inclusion criteria. The few studies found included both children and adults with the average age over 50 years and only few children. In addition, comparative studies and meta-analyses were heterogeneous in medication use with several confounders and no control groups were included. Therefore, a knowledge gap exists on this topic and better studies are needed to address this topic with the following research question:

Which prophylactic measures should be used in children (<18 years) undergoing radiological examinations with contrast agents to prevent symptoms of hypersensitivity reactions compared to other or no treatments?

 

P(atients): Children (<18 years) undergoing radiological examinations after administration of iodine-based contrast media.

I(ntervention): Prophylactic measures to prevent hypersensitivity reactions after contrast media administration.

C(ontrol): No prophylactic measures or a different prophylactic measure to prevent hypersensitivity reactions after contrast media administration.

O(utcome): Allergic reactions to contrast media, hypersensitivity reactions, type I/ type IV, severe allergic reaction.