Kennislacunes

This literature review shows there is a knowledge gap in the treatment of calcinosis cutis in patients with idiopathic inflammatory myopathy (IIM), for the research question: What are the positive and possible negative effects of the treatment of calcinosis in patients with IIM or (juvenile) dermatomyositis?

 

The available data is largely retrospective, uncontrolled, partly based on patients with underlying conditions other than IIM and lacks description of long-term effects of treatments which makes a substantiated recommendation difficult to give. There is therefore a great need for comparative research. However, given the rarity of the condition, large-scale research is difficult to achieve. The recent discovery of the mechanistic link with the JAK / STAT cascade (Chung & Chung, 2019; Kul Cinar ,2021) also offers a clue for further research.