Review protocol

Topic

Interventions/ epidemiology

Review question(s)

What are the effects of different types of therapy in patients with a personality disorder and a comorbidity?

 Sub-question(s)

Zijn er uit de literatuur aanwijzingen te destilleren op basis waarvan men af dient te wijken van de richtlijn (van de bijkomende stoornis?)

 Objectives

Relative efficacy of therapies

Benefits and harms of therapies

Criteria for considering studies for the review
  • Types of participants

People with a personality disorder and one of the following comorbidities:

  1. Clinical depression
  2. Post-traumatic stress disorder (PTSD)
  3. Attention Deficit Hyperactivity Disorder (ADHD)
  4. Addiction
  5. Eating disorders
  • Intervention
  1. Psychotherapy or pharmacotherapy
  • Comparator

Treatment as usual (TAU)

Waiting list or no treatment

Comparison with one or multiple other treatment(s)1

1NB with this comparator no conclusions can be drawn with respect to efficacy of individual treatment.
  • Critical outcomes

-
  • Important outcomes

Symptomatic recovery

Social recovery

Attrition (surrogate for adverse events)

End of treatment and follow-up measurements
  • Time

Studies of any duration were included
  • Study design

Systematic reviews and meta-analyses
  • Dosage

-
  • Study setting/country

Including primary, secondary, tertiary health and social care and healthcare settings

Search strategy

Databases searched: Pubmed, PsycInfo, Cochrane database

of systematic reviews

Date limiters: from 01-01-2010

Other limiters: Only English, German and Dutch articles

Study design filter used

Yes. Systematische reviews and meta-analyses

Question specific search strategy

No

Searching other resources

-

The review strategy

The information specialist will carry out the search strategy. The reviewer(s) will select the studies in two phases, based on the ‘Criteria for considering studies for the review’ above:

  1. Based on title and abstract. When included or in doubt:
  2. based on full text.

A second reviewer is available for cross-checking, help and advice.

If a recent, well performed systematic review appropriate to the review question is found, it will not be supplemented with studies published since the review.

Certainty of all outcomes will be assessed using GRADE. Results are summarised and described narratively.

Note.