Methodologische checklijst: belang patiëntgerelateerde factoren

Table of quality assessment – prognostic studies

Research question: which patient related risk factors predict outcome after use of the Ponseti method for treatment of idiopathic clubfeet?

Study reference (first author, year of publication)	Was there a representative and well-defined sample of patients at a similar point in the course of the disease? (yes/no/unclear)	Was follow-up sufficiently long and complete? (yes/no/unclear)	Was the outcome of interest defined and adequately measured? (yes/no/unclear)	Was the prognostic factor of interest defined and adequately measured? (yes/no/unclear)	Was loss to follow-up / incomplete outcome data described and acceptable? (yes/no/unclear)	Was there statistical adjustment for all important prognostic factors? (yes/no/unclear)	Level of evidence
Zhang 2012	Yes	Yes	Yes	Yes	Yes	No*²	B
Ramirez 2011	Yes	Yes	Yes	Unclear*¹	Yes	No*²	B
Avilucea 2009	Yes	Yes	Yes	Unclear*¹	Yes	No*²	B
Haft 2007	Unclear*³	Yes	Yes	Unclear*¹	Yes	No*²	B
Dobbs 2004	Yes	Yes	Yes	Unclear*¹	Yes	No*²	B
*studies below are also included in the evidence-table of UV-2*
Clarke 2011	Yes	Yes	Unclear	Yes	Unclear	No*²	B
Halanski 2010	Yes	Yes	Yes	Unclear*¹	Unclear	Unclear	B
Bor 2009	Yes	Yes	Yes	Unclear*¹	Unclear	No*²	B
Changulani 2006	Yes	Unclear	Yes	Unclear*¹	Yes	No*⁴	C
Ponseti 2006	Yes	Unclear	Yes	Unclear*¹	Yes	No*⁴	C
Cooper 1995	Yes	No*⁶	Yes	Yes	No*⁶	No*²	B
Morcuende 2005*⁵	Yes	Unclear	Yes	Unclear*¹	Yes	No*²	B
Morcuende 2004	Yes	Unclear	Yes	Unclear*¹	Yes	No*²	B

*¹non-compliance of bracing not measured objectively, but based on parental report

*²only univariate analysis, no correction for potential confounders (usually not possible due to small study size)

*³parents chose between Ponseti and operative pathway, and only Ponseti patients were analyzed (potential selection bias)

*⁴rates only, no statistical analysis provided

*⁵this study compares Ponseti treatment with accelerated Ponseti treatment, and analyzes compliance with bracing in both treatment groups

*⁶high loss to follow-up