Bijlage 1D

Bijlage 1D-1. Gedetecteerde aandoeningen bij aanvullend onderzoek van kinderen met kleine lengte/groeiafbuiging (buitenlandse studies, alle in tertiaire centra)*

 

(Shu, 2002)

(Strufaldi, 2005)

(Bhadada, 2008)

(Bhadada, 2011)

(Papadimitriou, 2012)

(Sisley, 2013)

(Singh, 2015)

Land

Taiwan

Brazilië

India

India 1995-2005

Griekenland

USA

India

Inclusie criteria

LSDS <-2

Lftd>2, lengte<P5

LSDS<-2,5, HV<P5, L-TH-SDS<-2

LSDS<-2,5, HV<P5, L-TH-SDS<-2

Verwezen

LSDS<-2, nl HV, A, LO

Verwezen

N (jongens/ meisjes)

655 (303/352)

99 (63/36)

176

190 - 256

295 (162/133)

235

(M 73%)

432 (238/194)

Leeftijd (jr)

Range 6-15

8,6

Meesten 10-15

Meesten

10-15

8,3(3,6)/

9,1(3,6)

10,1(4,3) (0,8-17,6)

 

Lengte-SDS

-2,6

 

 

 

-2,3(0,6)/

-2,1(0,5)

-2,5(0,5) (-4,8-2,0)

 

TH-SDS

-1,3

P: 35% <P5

M: 53% <P5

 

 

-0,9(0,6)/

-1,1(0,7)

 

 

Skeletleeftijd achterstand

-1,3

34% <-2 SDS

 

 

-1,3(0,9)/

-0,9(0,9)

 

 

Eindlengte pred SDS

 

 

 

 

-1,4(0,8)/

-1,7(0,8)

 

 

Groeisnelheid SDS

 

 

 

 

-0,6(1,5)/-0,5(1,7)

 

 

Turner-syndroom

1%, 3% (m), 11% (tests)

 

6%, 13% (m)

4%-4%, 8% (m)

-/1,5%

 

8%**

SGA

15%

14%

 

 

3,7%/7,5%

 

0,2%

Skelet dyspl

2%

 

9%

6% - 7%

2,5%/1,5%

 

 

Syndroom

1%

9%

5%

7% - 4%

1,2%/3,0%

 

 

NF1

0, 2%

 

 

 

-/2,3%

 

 

GHD

8%

2%

14%

15% -19%

11,1%/9,0%

 

27%

Hypothyr

0,3%

 

14%

18% - 14%

-/-

 

5%

Coeliakie

Niet onderzocht

 

15%

2% - 14%

-/2,3%

0,9%

11%

Andere sec oorzaken

Anemie 1%

4%

19%

32% - 21%

 

0,4%

(IGF1R

13%

Idiopathisch

65%

58%

11%

8% - 10%

80%/72%

99%

18%

?

 

13%

8%

 

 

 

15%

Totaal path

29,5%

29%

82%

84% - 83%

18,5%

1,3%

64,2%

 

Afkortingen: A = anamnese; dyspl = dysplasia; GHD = groeihormoondeficientie; HV = height velocity (groeisnelheid); hypothyr = hypothyreoidie; LO = lichamelijk onderzoek;

L-TH-SDS = lengte-SDS minus Target Height-SDS; Lftd = leeftijd; LSDS = lengte-SDS; (m) = van meisjes; path = pathologie; sec = secundaire

*percentages (>1) zijn weergegeven zonder decimalen. ** inclusief skeletdysplasie

 

Bijlage 1D-2. Gedetecteerde aandoeningen bij aanvullend onderzoek van kinderen met kleine lengte/groeiafbuiging (buitenlandse studies, alle in tertiaire centra). Getallen ontleend aan Lashari (2014)

 

Lindsay

1994

Moayeri 2004

 

Bhadda

2003

Colaco

1991

Lashari

2014

Land

USA

Iran

India

India

Pakistan

n

555

426

352

200

100

GHD

2,5%

23,4%

7,4%

19,5%

13%

Turner-syndroom

1,5%

4,5%

7,4%

7,4%

3%

Hypothyreoidie

1%

8%

14,2%

10%

15%

Chronische systeemziekten

10%

4%

12,4%

8,5%

17%

ISS

80%

47%

15,9%

20,5%

30,1%

 

Literatuur

Bhadada SK, Bhansali A, Kochhar R, et al. Does every short stature child need screening for celiac disease? J Gastroenterol Hepatol. 2008;23(8 Pt 2):e353-356. PMID: 18086116.

Bhadada SK, Bhansali A, Ravikumar P, et al. Changing scenario in aetiological profile of short stature in India-growing importance of celiac disease: a study from tertiary care centre. Indian J Pediatr. 2011;78(1):41-44. PMID: 20882429.

Lashari SK, Korejo HB, Memon YM. To determine frequency of etiological factors in short statured patients presenting at an endocrine clinic of a tertiary care hospital. Pak J Med Sci. 2014;30(4):858-861. PMID: 25097532.

Papadimitriou A, Douros K, Papadimitriou DT, et al. Characteristics of the short children referred to an academic paediatric endocrine clinic in Greece. J Paediatr Child Health. 2012;48(3):263-267. PMID: 22112203.

Shu SG, Chen YD, Chi CS. Clinical evaluation of short children referred by school screening: an analysis of 655 children. Acta Paediatr Taiwan. 2002;43(6):340-344. PMID: 12632788.

Singh P, Sharma PK, Agnihotri A et al. Coeliac disease in patients with short stature: A tertiary care centre experience. Natl Med J India. 2015;28(4):176-180. PMID: 27132724.

Sisley S, Trujillo MV, Khoury J, et al. Low Incidence of Pathology Detection and High Cost of Screening in the Evaluation of Asymptomatic Short Children. J Pediatr. 2013;163(4):1045-1051. PMID: 23706358.

Strufaldi MW, Silva EM, Puccini RF. Follow-up of children and adolescents with short stature: the importance of the growth rate. Sao Paulo Med J. 2005;123(3):128-133. PMID: 16021276.