GRADE evidence profile

Author(s): Mariska Tuut

Date: 25-02-2016

Question: Low protein intake compared to normal protein intake in patients with chronic kidney disease and GFR > 30

Setting: 1e en 2e lijn

Bibliography: Rughooputh, 2015; Fouque, 2009; Nezu, 2013

Quality assessment

№ of patients

Effect

Quality

Importance

№ of studies

Study design

Risk of bias

Inconsistency

Indirectness

Imprecision

Other considerations

low protein intake

normal protein intake

Relative
(95% CI)

Absolute
(95% CI)

GFR (follow up: 12 months)

12

randomised trials

serious 1

not serious

not serious

not serious

none

652

664

-

MD 0.95 fewer
(2.12 fewer to 0.22 more)

⨁⨁⨁™
MODERATE

CRITICAL

CI: Confidence interval; MD: Mean difference

  1. Slight problems with concealment of allocation