Tabel geїncludeerde systematische reviews

N	(Eerste) Auteur	Tijdschrift	Domein	Design	Populatie	Interventie	Controle	Uitkomstmaat	Resultaten (95% CI)	In-/exclusie
1	Mikkelsen EJ	J Am Acad Child Adolesc Psychiatry 2001;40:1146-58	diagnostics/ therapy	Review	children with enuresis en encopresis	-	-	-	-	ex
2	Palsson OS	Appl Psychophysiol Biofeedback. 2004;29:153-74	therapy	Review	children and adults with funct.anorec. disorders	-	-	-	-	ex
3	Coulter ID	Alt.Therap. in Health and Medicine 2002;8:76-83.	therapy	Sr	children and adults with gi-conditions	Biofeedback	no biofeedback	Stool frequency, fec. incontinence and use of laxatives	4 out of 5 rct’s: ns	in
4	Heymen S	Dis. of the Colon and Rectum 2003;46: 1208-17	therapy	Sr	children and adults with constipation	-	-	-	-	ex
5	Heymen S	Dis. of the Colon and Rectum 2001;44: 728-36	therapy	Sr	children and adults with fecal incontinence	-	-	-	-	ex
6	Reuchlin-Vroklage LM	Arch. of Ped. and Adolesc. Med. 2005;159: 671-8	diagnostics	Sr	children with constipation	abd. radiography	no comparison	association between clin. and radiolog. diagnosis of constipation	Beckmann et al: LR 1.2 (1.0-1.4) Leech et al: LR 3.0 (1.6-4.3) Benninga et al: LR 1.0 (0.5-1.6) Barr et al: LR 8.2 (0.7-17.1 )	in
7	Berger MY	J Pediatr. 2012 Jul;161(1):44-50	diagnostics	Sr	children with constipation	abd. radio-graphy, colonic transit time or rectal ultrasound	no comparison	association between clin. and radiolog. diagnosis of constipation	XBOZ: see nr 6 CTT: De Lorijn: sens 71%, spec 95% Ultrasound: Klijn: sens 100%, spec 89% Joensson: sens 56%, spec 96%	in
8	Van den Berg MM	Am. J of Gastroenterol. 2006;101: 2401-09	epidemiol./ prognosis	Sr	children from 0-18 years	-	-	Prevalence	0,7-29,6%	in
9	Bell EA	Ann. Pharmacother 2004;38:686-93	therapy	Sr	children with constipation and PEG 3350 use	-	-	-		ex
10	Brazzelli M	Cochrane Database Syst Rev 2001;(4): CD002240	therapy	Meta	children with fecal incont.	behav.and/or cogn.interv.	treatment or no treatment	fec.incont.> 12 months when biofeedback was added to convent. treatment success rate at 24 months when adjunct of anorectal manometry to convent. treatment soiling episodes when behaviour modification was added to laxatives	OR 1.11(0.78-1.58) OR 1.40(0.72-2.73) OR 0.14(0.04-0.51 at 3 months) OR 0.20(0.06-0.65 at 12 months)	in
11	Evans BW	Cochrane Database Syst Rev 2007;(4): CD003960.	therapy	meta	adults and children ≥ 12 years with ibs (Irritable Bowel Syndrome) or chronic constipation	-	-			ex, tegaserod not available anymore due to side effects
12	Gladman MA	Ann Surg 2005;241, 562-74	therapy	sr	adults with idiopathic megabowel	-	-			ex
13	Huertas-Ceballos A	Cochrane Database Syst Rev 2008;(1): CD003017	therapy	meta	children with recurrent abdominal pain and ibs (Irritable Bowel Syndrome) without constipation	-	-			ex
14	Klassen TP	Evid.Rep Technol. Assess 2006;147:1-57.	therapy	sr	all children	-	-			ex, not applicable to our population
15	Mendoza J	Aliment Pharmacol Ther 2007;26: 9-20	therapy	sr	children and adults using sodium phosphate enema	-	-			ex
16	Price KJ	Cochrane Database Syst Rev 2001;(3), CD002040.	therapy	sr		stimulant laxatives	Placebo or alternative treatment	no trials found		in
17	Szajewska H	J Pediatr Gastroenterol Nutr 2006;42: 454-75.	therapy	review	children with constipation	lactobacillus GG and lactulose	lactulose	treatment success:> 3 bm p/week without soiling at 12 weeks and 24 weeks mean number of bm/week or fecal soiling per week at 4,8 and 12 weeks	12 weeks: 68% vs 72% ns 24 weeks: 65% vs 64% ns ns	in
18	Pijpers MAM	Arch Dis Child.2009; 94: 117-131	therapy	sr	children with constipation	laxatives and dietary measures	different strategies		pooling not possible due to heterogeneity of included studies	in
19	Pijpers MAM	J Pediatr Gastroenterol Nutr. 2010 Mar;50(3):256-68	prognosis	sr	children with constipation	predictive factors of childhood constipation with or without treatment			pooling not possible due to heterogeneity of included studies	in
20	Lee-Robichaud H	Cochrane Database Syst Rev. 2010;(7): CD007570	therapy	sr	children and adults with chronic constipation	Lactulose	Polyethylene Glycol	relief of abdominal pain stool frequency	OR 0.40 (0.23 to 0.69) MD 1.57 lower (2.77 to 0.36 lower)	in
21	Candy D	Arch Dis Child. 2009;94:156-60.	therapy	sr	patients aged <18 years with primary chronic constipation	Polyethylene Glycol	Placebo or other active comparator		pooling not possible due to heterogeneity of included studies	in
22	Tabbers MM	BMJ Clin Evid. 2010 ; 6;2010. pii: 0303.	therapy	sr	infants and children under 16 years of age with constipation	anal dilatation, behavioural treatments, bulk-formers,enemas, faecal softeners, fibre, macrogols, oral fluids, osmotic laxatives, pre-and probiotics, stimulant laxatives, and surgical disimpaction.	Any other treatment or no treatment	treatment success quality of life	See specific chapter /per intervention	in
23	Gordon M	Evid Based Child Health. 2013;8(1):57-109	therapy	sr	children aged 0 -18 years with functional constipation	osmotic and stimulant laxatives	placebo or another intervention	number of stools per week	Different for each specific comparison. Overall: pooled analyses suggest that PEG preparations may be superior to placebo, lactulose and milk of magnesia for childhood constipation.	in
24	Tabbers MM	Pediatrics. 2011;128:753-61	therapy	sr	children aged 0 -18 years with functional constipation	non-pharmacolo-gical treatments: fiber,fluid,physical movement, pre-and probiotics, behavioural therapy, multi-disciplinary treatment and alternative medicine.	placebo, no treatment, another alternative treatment or medication		pooling not possible due to heterogeneity of included studies	in
25	Chmielewska A	World J Gastro-enterol. 2010;16:69-75.	therapy	sr	adults and children with constipation	probiotics	placebo or no intervention	treatment success	pooling not possible due to heterogeneity of included studies	in