Kennisvragen

During the development of this module, a systematic search was conducted to find studies that could answer the research question. Through the use of a systematic literature review with an assessment of the strength of evidence, it has become clear that there are still knowledge gaps within this module. The guideline panel believes that further research is desirable to provide clearer answers to practical questions in the future.

Knowledge question

What is the optimal medical therapy for necrotizing otitis externa? 

Explanation

There is a paucity of evidence on the optimal empirical or directed medical treatment of necrotizing otitis externa. Although anecdotal evidence and evidence from other fields aids in giving guidance for treatment policy, more certainty is needed around the optimal make-up of the treatment regime and the optimal administration route / moment for IV-to-oral switch. A randomized controlled trial comparing several strategies (e.g., empirical ciprofloxacin oral therapy vs ceftazidime iv therapy) would be beneficial to yield more evidence to guide policy and improve outcomes.