Kennisvragen

During the development of this module, a systematic search for studies addressing the research question was conducted. Through a systematic literature analysis and evidence assessment, it became clear that there are still knowledge gaps within this module. The working group believes that further research is necessary to provide clearer answers to practical questions in the future. 

Knowledge question

What is the added value of MRI or FDG-PET/CT to the normally used CT scan in the primary diagnosis of skull base osteomyelitis?

Explanation

This is the original search question. We found no comparative literature regarding all modalities. To fully answer this question, a comparative cohort in which all relevant imaging modalities are performed on patients with NOE should be conducted.

Knowledge question

Is dual energy CT an option for diagnosing NOE?

Explanation

Dual energy CT is used in osteomyelitis of other parts of the body. It shows edema of the bone marrow. It may also be cheaper than MRI and PET/CT. For NOE, no studies have been perfomed with this modality however.