Kennislacunes

Er is geen relevante literatuur gevonden wat betreft diagnostische of exploratieve chirurgie ten opzichte van niet-invasieve diagnostiek of minimaal invasieve diagnostiek bij patiënten met PTO (buiten het hoofd-hals gebied). 

What is the diagnostic yield, in terms of finding an indication for primary origin, of diagnostic or explorative surgery compared to non-invasive diagnostic tests or minimally invasive diagnostic tests in patients with a metastasis (not in the head-neck area) of a (provisional) cancer of unknown primary?

P: patients with a metastasis (not in the head-neck area) of a (provisional) cancer of unknown primary

I (intervention): explorative surgery 

C (comparison): non-invasive diagnostic tests or minimally invasive diagnostic tests

R (reference standard): follow-up

O (outcome measure): indication for origin of the primary tumour

Timing and setting: when physical examination, imaging and endoscopy have not confirmed the origin of the primary tumour