Kennislacunes

De PICO vragen waren:

1. What are the effects of non-pharmacological interventions on hallucinatory- and/or delusional behaviour in adult patients with thinking and/or perception disorders after acquired brain injury?

P:	Patients with thinking and/or perception disorders after acquired brain injury
I:	Non-pharmacological interventions: cognitive rehabilitation therapy, cognitive behavioral therapy, psychoeducation, (temporary) admission to a structured department, environmental interventions to prevent overstimulation
C:	No treatment or care as usual
O:	Hallucinatory- and/or delusional behaviour

2. What are the effects of pharmacological interventions on hallucinatory- and/or delusional behaviour in adult patients with thinking and/or perception disorders after acquired brain injury?

P:	Patients with thinking and/or perception disorders after acquired brain injury
I:	Pharmacological interventions: atypical antipsychotics, classic antipsychotics, benzodiazepines, promethazine, antiepileptics;
C:	No treatment, placebo or care as usua
O:	Hallucinatory- and/or delusional behaviour

Voor de cruciale uitkomstmaat hallucinatoir en-/of waanachtig gedrag was de bewijskracht uit de literatuur zeer laag, omdat er geen literatuur beschikbaar was. Daarom is er onderzoek nodig naar de effecten van zowel niet-medicamenteuze als medicamenteuze behandelingen bij patienten met denk- en/of waarnemingsstoornissen en niet-aangeboren hersenletsel (zie PICO’s). Het gaat hierbij om de genoemde vormen van medicamenteuze behandelingen, maar ook om andere (nieuwe) medicamenteuze behandelingen.