Zoekstrategie Voeding

KEY QUESTION 6

1. Key question

Uitgangsvraag 6: Is er bij patiënten met een partiële of totale maagresectie een verschil in mate van vitamine B12 deficiëntie bij oraal/nasaal toediening vergeleken met intramusculaire toediening?
P	Mensen een partiële of totale maagresectie
I	Oraal of nasaal vitamine B12 preparaat
C	Intramusculaire vitamine B12 suppletie
O	Percentage patiënten met een vitamine B12 deficiëntie

Inclusiecriteria

Studies	(1) meta-analyses, systematische reviews, (2) randomised controlled trials (RCT), controlled clinical trials (CCT)
Periode (vanaf tot):	2006-2014
Databases:	Medline, Embase, Cochrane (CDSR)
Taal:	Eng. Ned.

2. Search strategy

Searches were run on January 11, 2015. Detailed search strings are given below.

3. Search Results

The search resulted in 336 single citations. 320 Citations were excluded based on title &/ abstract. 16 Citations were requested full text. One study was included after full text review (see Table 1).

Table 1 Inclusion or exclusion of articles requested full text

	Reference	In/Ex	Reason for exclusion
1.	Cyanocobalamin nasal spray (Nascobal) for vitamin B12 deficiency: horizon scanning technology briefing (Structured abstract). Health Technology Assessment Database, 2007(4): p. 5.	Ex	Narrative review (no systematic selection, no quality appraisal, narrative presentation of results)
2.	Oral or intramuscular vitamin B12? Drug Ther Bull, 2009. 47(2): p. 19-21.	Ex	Narrative review (no systematic selection, no quality appraisal, narrative presentation of results)
3.	Andres, E., et al., Oral cobalamin (vitamin B(12)) treatment. An update. Int J Lab Hematol, 2009. 31(1): p. 1-8.	Ex	Narrative review (no systematic selection, no quality appraisal, narrative presentation of results)
4.	Andres, E., H. Fothergill, and M. Mecili, Efficacy of oral cobalamin (vitamin B12) therapy. Expert Opin Pharmacother, 2010. 11(2): p. 249-56.	Ex	Narative review (no quality appraisal, narrative presentation of results. Two included RCTs also included in Butler 2006)
5.	Andres, E., et al., Update of oral vitamin B12. Ann Endocrinol (Paris), 2009. 70(6): p. 455-61.	Ex	Other language (French)
6.	Andres, E., et al., Update on oral cyanocobalamin (vitamin B12) treatment in elderly patients. Drugs & Aging, 2008. 25(11): p. 927-32.	Ex	Narative review (no quality appraisal, narrative presentation of results)
7.	Butler, C.C., et al., Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: a systematic review of randomized controlled trials. Fam Pract, 2006. 23(3): p. 279-85.	Ex	Other population (mixed population, patients with gastrectomy apparently not included)
8.	Castelli, M.C., et al., Comparing the efficacy and tolerability of a new daily oral vitamin B12 formulation and intermittent intramuscular vitamin B12 in normalizing low cobalamin levels: a randomized, open-label, parallel-group study. Clin Ther, 2011. 33(3): p. 358-371.e2.	Ex	Other population (mixed population, patients with gastrectomy included but unclear how many and subgroup analyses for this group not given)
9.	Duyvendak, M. and G.J. Veldhuis, Oral better than parenteral supplementation of vitamin B12. Nederlands Tijdschrift voor Geneeskunde, 2009. 153.	Ex	Narrative review (no quality appraisal, narrative presentation of results)
10.	Health Quality, O., Vitamin B12 and cognitive function: an evidence-based analysis. Ontario Health Technology Assessment Series, 2013. 13(23): p. 1-45.	Ex	Other comparison
11.	Hoey, L., J.J. Strain, and H. McNulty, Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials. Am J Clin Nutr, 2009. 89(6): p. 1981S-1996S.	Ex	Other population (not on patients with gastric resection)
12.	Kim, H.-I., et al., Oral vitamin B12 replacement: an effective treatment for vitamin B12 deficiency after total gastrectomy in gastric cancer patients. Ann Surg Oncol, 2011. 18(13): p. 3711-7.	In
13.	Kripke, C., Is oral vitamin B12 as effective as intramuscular injection? Am Fam Physician, 2006. 73(1): p. 65.	Ex	Other study type (abstract of a systematic review)
14.	Lin, J., G. Kelsberg, and S. Safranek, Clinical inquiry: Is high-dose oral B12 a safe and effective alternative to a B12 injection? J, 2012. 61(3): p. 162-3.	Ex	Narrative review (no systematic search and selection, no quality appraisal, narrative presentation of results)
15.	Majumder, S., et al., Vitamin B12 deficiency in patients undergoing bariatric surgery: preventive strategies and key recommendations. Surg, 2013. 9(6): p. 1013-9.	Ex	Narrative review (no systematic selection, no quality appraisal, narrative presentation of results)
16.	Sanz-Cuesta, T., et al., Oral versus intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency: a pragmatic, randomised, multicentre, non-inferiority clinical trial undertaken in the primary healthcare setting (Project OB12). BMC Public Health, 2012. 12(394).	Ex	Other study type (protocol)

SEARCH STRINGS

4. medline (via OVID)

1 randomized controlled trial.pt. (401543)

2 controlled clinical trial.pt. (90838)

3 randomized.ab. (296619)

4 placebo.ab. (155459)

5 clinical trials as topic.sh. (176856)

6 randomly.ab. (207730)

7 trial.ti. (129316)

8 1 or 2 or 3 or 4 or 5 or 6 or 7 (914231)

9 exp animals/ not humans.sh. (4100811)

10 8 not 9 (840241)

11 meta-analysis.mp,pt. or review.pt. or search:.tw. (2147657)

12 prospective studies/ (392974)

13 10 or 11 or 12 (3156567)

14 gastrectomy.mp. or exp Gastrectomy/ (32694)

15 exp Gastric Bypass/ (5709)

16 exp Vitamin B 12/ (19166)

17 vitamin B12.mp. (12634)

18 14 or 15 (37923)

19 16 or 17 (23374)

20 exp Vitamin B 12 Deficiency/ (9920)

21 14 or 15 or 20 (47493)

22 13 and 21 and 19 (901)

23 limit 22 to yr="2006 - 2014" (335)

Database: Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations

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1 randomized controlled trial.pt. (4614)

2 controlled clinical trial.pt. (359)

3 randomized.ab. (28906)

4 placebo.ab. (10622)

5 clinical trials as topic.sh. (748)

6 randomly.ab. (24975)

7 trial.ti. (12372)

8 1 or 2 or 3 or 4 or 5 or 6 or 7 (62150)

9 exp animals/ not humans.sh. (20889)

10 8 not 9 (61360)

11 meta-analysis.mp,pt. or review.pt. or search:.tw. (69529)

12 10 or 11 (124527)

13 gastrectomy.mp. or exp Gastrectomy/ (1595)

14 exp Gastric Bypass/ (74)

15 exp Vitamin B 12/ (85)

16 vitamin B12.mp. (765)

17 13 or 14 (1652)

18 15 or 16 (799)

19 exp Vitamin B 12 Deficiency/ (24)

20 13 or 14 or 19 (1676)

21 12 and 20 and 18 (8)

22 limit 21 to yr="2006 - 2014" (7)

5. Embase (via OVID)

#10. 'gastrectomy'/exp OR 'stomach bypass'/exp OR gastrectom*:ab,ti OR 'cyanocobalamin deficiency'/exp AND ('cyanocobalamin'/exp OR (vitamin NEAR/1 b12):ab,ti) AND ([cochrane review]/lim OR [systematic review]/lim OR [controlled clinical trial]/lim OR [randomized controlled trial]/lim OR [meta analysis]/lim) AND ([article]/lim OR [article in press]/lim OR [review]/lim) AND ([dutch]/lim OR [english]/lim) AND [2006-2015]/py

#9. 'gastrectomy'/exp OR 'stomach bypass'/exp OR gastrectom*:ab,ti OR 'cyanocobalamin deficiency'/exp AND ('cyanocobalamin'/exp OR (vitamin NEAR/1 b12):ab,ti)

#8. 'cyanocobalamin'/exp OR (vitamin NEAR/1 b12):ab,ti

#7. (vitamin NEAR/1 b12):ab,ti

#6. 'cyanocobalamin'/exp

#5. 'gastrectomy'/exp OR 'stomach bypass'/exp OR gastrectom*:ab,ti OR 'cyanocobalamin deficiency'/exp

#4. 'cyanocobalamin deficiency'/exp

#3. gastrectom*:ab,ti

#2. 'stomach bypass'/exp

#1. 'gastrectomy'/exp

6. Cochrane DAtabase of systematic reviews (via OVID)

#1 MeSH descriptor: [Gastrectomy] 1 tree(s) exploded

#2 gastrectom*:ti,ab

#3 MeSH descriptor: [Gastric Bypass] 1 tree(s) exploded

#4 MeSH descriptor: [Vitamin B 12 Deficiency] 1 tree(s) exploded

#5 #1 or #2 or #3 or #4

#6 MeSH descriptor: [Vitamin B 12] 1 tree(s) exploded

#7 vitamin B12:ti,ab

#8 #6 or #7

#9 #5 and #8