Question

Is there possible infertility after breast cancer treatment?

Recommendation

Premenopausal women with breast cancer should be informed as early as possible about possible infertility after cancer treatment, and the possibilities to deal with this.

 

If there is a desire to retain fertility, the woman should receive an early referral to a centre with expertise in fertility preservation techniques. In this case, any oral contraceptives being taken should be continued to save time for IVF or egg cell cryopreservation.

Conclusions

 

Level 3

Chemotherapy-induced infertility affects quality of life.

 

C          Partridge, 2004; Rodriguez Wallberg, 2010

 

Level 3

Prior to chemotherapy, it is possible to perform IVF, egg cell cryopreservation or ovarian cryopreservation to protect against infertility.

 

C          Lee, 2006, Gerber 2008, NVOG 2007

Literature summary

Infertility as a result of chemotherapy is experienced by patients as a serious side effect with loss of quality of life [Rodriguez-Wallberg, 2010]. In a retrospective study of 657 premenopausal patients with breast cancer, it was found that 26% had not been informed about the risk of infertility as a result of treatment [Partridge, 2004]. According to Jenninga (2008), quality of life after treatment, including the ability to start a family, must be incorporated in the treatment plan for breast cancer patients. Information about the influence of treatment on fertility and the possibilities to preserve fertility should be provided to patients as early as possible, so a patient may become well informed by a fertility specialist and there is enough time to keep all options open, such as freezing egg cells, embryo’s or ovarian tissue.

Causes of infertility after breast cancer

Chemotherapy

The most important determinants of loss in ovarian function through chemotherapy are the age at which the patient is treated with chemotherapy, the dose and number of cycles of the chemotherapy administered [Petrek, 2006; Lee, 2006]. Alkylating therapy, especially cyclophosphamide, has a negative effect on fertility. It is also possible for anthracyclines, taxanes and platinum analogues to have negative effects [Tham, 2007; Perez-Fidalgo, 2010]. Premenopausal patients treated with cyclophosphamide have a reduced ovarian function after such treatment, corresponding to a physiological reduction over a period of 10 years. Reduced ovarian reserve after chemotherapy does not need to be associated with amenorrhoea [Petrek, 2006; Walshe, 2006; Gerber, 2008].

 

Hormonal treatment

A hormone receptor-positive breast cancer is diagnosed in 60% of premenopausal patients, for which long-term adjuvant hormonal treatment (tamoxifen, LHRH analogues) is recommended. Pregnancy is discouraged during this treatment. The ovarian reserve reduces exponentially from the age of 35 [Faddy, 2000]. By postponing their desire to have children, women run an extra risk of infertility due to increased age.

 

Radiotherapy

The radiotherapy dose in the treatment of breast cancer is generally not so high that infertility is to be expected [Wallace, 2005; Wo, 2009].

 

Preservation of fertility

The guideline “Cryopreservatie van ovariumweefsel” (ovarian tissue cryopreservation) concludes that the following can be chosen prior to chemotherapy: laparoscopic oophorectomy with subsequent cryopreservation, or freezing egg cells or embryos after IVF treatment [NVOG, 2007]. Controlled ovarian stimulation during IVF treatment is dependent on the cycle of the patient. Patients who use oral contraceptives at the time of a breast cancer diagnosis, must be advised to continue these sinceit saves time for IVF treatment. If there is an oestrogen receptor-positive tumour, an alternative stimulation protocol with tamoxifen or other agents rather then estrogens should be considered [Huang, 2007].

A good ovarian reserve is a condition for all three possibilities (IVF, egg cell vitrification and ovarian cryopreservation). IVF seems preferable for women with a male partner and egg cell cryopreservation for women without a partner. The procedure for harvesting egg cells takes 2-4 weeks as long as the woman has not stopped taking oral contraceptives. A laparoscopic oophorectomy for cryopreservation does not require hormonal preparation like the other two methods.

Early referral to a specialised fertility preservation centre is a condition for a successful clinical trajectory.

 

Other interventions

There are two diametrically opposed views about the possibility of protecting ovarian function during chemotherapy by means of ovarian suppression (GnRH analogues or LHRH analogues) [Blumenfeld, 2007; Lawrenz, 2010; Oktay, 2007]. Most studies use the occurrence of chemotherapy-induced amenorrhoea (CIA) as outcome measure, instead of fertility and the associated chance of conceiving a child. The Zoladex Rescue of Ovarian Function (ZORO) study did not show a difference in CIA [Gerber, 2011]. The PROMISE GIM6 study showed that temporary ovarian suppression by triptorelin (GnRH analogue) in premenopausal women with early stage breast cancer provides a reduction in risk of CIA [Del Mastro, 2011]. However, the average age of this study population was relatively old (39 years) and the patients were only observed until one year after chemotherapy. As a result, use of GnRH analogues to protect ovarian function cannot be recommended on the basis of current data available, certainly not as fertility preservation.

Authorization date and validity

Last review : 13-02-2012

Last authorization : 13-02-2012

The national Breast Cancer guideline 2012 is a living guideline, in other words there is no standard term of revision. NABON continually watches at new developments and clinical problems in the areas of screening, diagnostics, treatment and aftercare, and whether this requires an update.

Initiative and authorization

Initiative : Nationaal Borstkanker Overleg Nederland

Authorized by:
  • Nederlandse Internisten Vereniging
  • Nederlandse Vereniging voor Heelkunde
  • Nederlandse Vereniging voor Psychiatrie
  • Nederlandse Vereniging voor Radiologie
  • Nederlandse Vereniging voor Radiotherapie en Oncologie

General details

Approximately 14,000 women (and 100 men) are diagnosed with invasive breast cancer each year in the Netherlands, and about 1,900 have an in situ carcinoma. A woman's risk of having breast cancer over the course of her life is 12-13%. This means that breast cancer is the most common form of cancer in women in the Netherlands. Early detection, particularly via national breast cancer screening, combined with adjuvant therapy followed by locoregional treatment, improves the prognosis in women with breast cancer

The guideline on Breast Cancer Screening and Diagnostics, published in 2000, was updated in 2007. In 2002, the first multidisciplinary National Breast Cancer Guideline was published, it was revised in 2004, 2005 and 2006. In 2008 both guidelines were combined to Breast Cancer Guideline, which 2012 revision is now effected.

Scope and target group

This guideline is written for all the members of the professional groups that have contributed to its development.

 

This guideline is a document with recommendations and instructions to support daily practice. The guideline is based on the results of scientific research and expert opinion, with the aim of establishing good medical practice. It specifies the best general care for women with (suspected) breast cancer and for those who are eligible for screening. The guideline aims to serve as a guide for the daily practice of breast cancer screening, diagnostics, treatment and aftercare. This guideline is also used in the creation of informational materials for patients, in cooperation with the KWF (Dutch Cancer Society).

Member of workgroup

A core group consisting of a radiologist, surgeon, pathologist, medical oncologist and radiation therapist began preparing for the revision of the breast cancer practice guidelines in 2009. A multidisciplinary guideline development group was formed in early 2010 to implement the revision. This group consisted of mandated representatives from all of the relevant specialisations concerned with breast cancer, plus two delegates from the BVN (Dutch Breast Cancer Society) (see list of guideline development group members). The benefits of such a multidisciplinary approach are obvious: not only does it best reflect the care, but it offers the greatest possible expertise for the guideline. In composing the development group, geographic distribution of the members, balanced representation of the various organisations and agencies concerned, and a fair distribution in academic background were taken into account as much as possible.

 

The guideline development group received procedural and administrative support from IKNL (Comprehensive Cancer Centre for the Netherlands) and support on methodology from Bureau ME-TA. Partial funding was obtained from SKMS (Quality Funds Foundation of Dutch Medical Specialists). This subsidy would not have been possible without the extensive assistance provided by the NVvR (Radiological Society of the Netherlands).

Declaration of interest

Partial funding for the guideline revision was obtained from the Society of Dutch Medical Specialists in the framework of the SKMS. IKNL sponsored some of the cost. On two occasions, as well as at the beginning and end of the process, all of the members of the guideline development group were asked to fill out a statement of potential conflicts of interest, in which they stated their relationship with the pharmaceutical industry. A list of these statements of interest can be found in the appendices.

Patient involvement

In developing this guideline, four clinical questions were formulated. These questions emerge from an inventory of clinical problems collected in the field from professionals, patients and patient representatives.

 

Also, A multidisciplinary guideline development group was formed in early 2010 to create and implement the revision. This group consisted of mandated representatives from all of the relevant specialisations concerned with breast cancer, plus two delegates from the BVN (Dutch Breast Cancer Society).

 

Method of development

Evidence based

Implementation

Feasibility has been taken into account in developing the guideline. This included attention to factors that could promote or hinder putting the advice into practice. Examples include the implementation of an analysis of problems, the multidisciplinary composition of the guideline development group, and making active use of support from the guideline development group members. Presenting the draft guideline to the field and communicating what, if anything, is being done with the responses, also promotes implementation. In this manner, a guideline has been developed that answers current questions in the field.

The guideline is distributed widely and is available in digital form on the Dutch Guideline Database. The guideline may also be brought to the attention of a wider audience in other periodicals or continuing education sessions, for example. To promote use of the guideline, we recommend that the regional tumour working groups and group practices, as well as scientific and professional organisations, repeatedly bring the guideline to the attention of their members. Any problems that may arise in using the guidelines can then be discussed and, when appropriate, submitted to the national guideline development group, as it is a "living" guideline. If desirable, parts of the guideline can be made more explicit by formulating regional additions or translation to the local situation in departmental and/or hospital protocols.

In principle, indicators are determined during development of the guideline that can be used to monitor implementation of the recommendations. Via a documentation project, these indicators can then be used to determine the extent of compliance with the guideline. The information from the documentation project becomes input for the revision of the guideline.

Methods and proces

This module has been evidence-based revised in 2008 and consensus based updated in 2012.

 

A revision of an existing guideline consists of revised and updated text. Revised text is new text based on an evidence-based review of the medical literature; updated text is the old guideline text which has been edited by the experts without performing a review of medical literature. Each section of the guideline states what type of revision has taken place. Each chapter of the guideline is structured according to a set format, given below. The purpose of this is to make the guideline transparent, so that each user can see on what literature and considerations the recommendations are based on.

 

Description of the literature

To the greatest extent possible, the answers to the fundamental questions (and therefore the recommendations in this guideline) were based on published scientific research. The articles selected were evaluated by an expert in methodology for their research quality, and graded in proportion to evidence using the following classification system:

 

Classification of research results based on level of evidence

A1

Research   on the effects of diagnostics on clinical outcomes in a prospectively   monitored, well-defined patient group, with a predefined policy based on the   test outcomes to be investigated, or decision analysis research into the   effects of diagnostics on clinical outcomes based on results of a study of   A2-level and sufficient consideration is given to the interdependency of   diagnostic tests.

A2

Research   relative to a reference test, where criteria for the test to be investigated   and for a reference test are predefined, with a good description of the test   and the clinical population to be investigated; this must involve a large   enough series of consecutive patients; predefined upper limits must be used,   and the results of the test and the "gold standard" must be   assessed independently. Interdependence is normally a feature of situations   involving multiple diagnostic tests, and their analysis must be adjusted   accordingly, for example using logistic regression.

B

Comparison   with a reference test, description of the test and population researched, but   without the other features mentioned in level A.

C

Non-comparative   trials

D

Opinions   of experts, such as guideline development group members

 

Conclusions

Based on the medical literature, one or more relevant conclusions are made for each section. The most important literature is listed according to the level of evidential strength, allowing conclusions to be drawn based on the level of
evidence. All the medical literature included in the conclusion is described in the bibliography.

 

Classification of conclusions based on literature analysis

1

Based   on 1 systematic review (A1) or at least 2 independent A2 reviews.

2

Based   on at least 2 independent B reviews

3

Based   on 1 level A2 of B research, or any level C research

4

Opinions   of experts, such as guideline development group members

 

Other considerations

Based on the conclusion(s), recommendations are made. However, there are other considerations that contribute to formulation of the recommendation besides literature evidence, such as safety, the patients' preferences, professional expertise, cost-effectiveness, organisational aspects and social consequences. The other considerations are mentioned separately. In this manner, it is clear how the guideline development group arrived at a particular recommendation.

 

Recommendations

The final wording of the recommendation is the result of the scientific conclusion, taking into account the other considerations. The purpose of following this procedure and drawing up the guidelines  in this format is to increase transparency.

 

References

An alphabetical list of literature references can be found at the end of the guideline.

 

All draft texts have been discussed by the guideline development group.

Search strategy

Searches are available upon request. Please contact the Richtlijnendatabase.